Decrease of Plasma Soluble (Pro)renin Receptor by Bariatric Surgery in Patients with Obstructive Sleep Apnea and Morbid Obesity

2018 ◽  
Vol 16 (4) ◽  
pp. 174-182 ◽  
Author(s):  
Tsuguo Nishijima ◽  
Koji Ohba ◽  
Shigeaki Baba ◽  
Testuya Kizawa ◽  
Keisuke Hosokawa ◽  
...  
Author(s):  
Maria Jesus Aviles Ingles ◽  
Monica Martinez Martinez ◽  
Damian Malia Alvarado ◽  
Milycen Garrido Cepeda ◽  
Maria del Carmen Abellan Martinez ◽  
...  

2017 ◽  
Vol 27 (9) ◽  
pp. 2338-2346 ◽  
Author(s):  
Raquel Tirado ◽  
Maria José Masdeu ◽  
Laura Vigil ◽  
Mercedes Rigla ◽  
Alexis Luna ◽  
...  

2020 ◽  
Vol 103 (8) ◽  
pp. 725-728

Background: Lifestyle modification is the mainstay therapy for obese patients with obstructive sleep apnea (OSA). However, most of these patients are unable to lose the necessary weight, and bariatric surgery (BS) has been proven to be an effective modality in selected cases. Objective: To provide objective evidence that BS can improve OSA severity. Materials and Methods: A prospective study was conducted in super morbidly obese patients (body mass index [BMI] greater than 40 kg/m² or BMI greater than 35 kg/m² with uncontrolled comorbidities) scheduled for BS. Polysomnography (PSG) was performed for preoperative assessment and OSA was treated accordingly. After successful surgery, patients were invited to perform follow-up PSG at 3, 6, and 12 months. Results: Twenty-four patients with a mean age of 35.0±14.0 years were enrolled. After a mean follow-up period of 7.8±3.4 months, the mean BMI, Epworth sleepiness scale (ESS), and apnea-hypopnea index (AHI) significantly decreased from 51.6±8.7 to 38.2±6.8 kg/m² (p<0.001), from 8.7±5.9 to 4.7±3.5 (p=0.003), and from 87.6±38.9 to 28.5±21.5 events/hour (p<0.001), respectively. Conclusion: BS was shown to dramatically improve clinical and sleep parameters in super morbidly obese patients. Keywords: Morbid obesity, Bariatric surgery, Obstructive sleep apnea (OSA)


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