Serum IgE Antibodies to Cow's Milk Proteins in Children With Differing Degrees of IgE-Mediated Cow's Milk Allergy: Analysis by Immunoblotting

1993 ◽  
Vol 7 (2) ◽  
pp. 99-109 ◽  
Author(s):  
MARK S. AMONETTE ◽  
STEPHEN I. ROSENFELD ◽  
ROBERT H. SCHWARTZ
Keyword(s):  
Milk Proteins ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Ige Antibodies ◽  
Serum Ige ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Ige Mediated ◽  
Cow’S Milk Proteins

scholarly journals Role of Cellular Immunity in Cow’s Milk Allergy: Pathogenesis, Tolerance Induction, and Beyond

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Juandy Jo ◽  
Johan Garssen ◽  
Leon Knippels ◽  
Elena Sandalova
Keyword(s):  
Cellular Immunity ◽  
Tolerance Induction ◽  
Milk Proteins ◽  
Cow’S Milk Allergy ◽  
Food Allergies ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Cow’S Milk Proteins

Food allergy is an aberrant immune-mediated reaction against harmless food substances, such as cow’s milk proteins. Due to its very early introduction, cow’s milk allergy is one of the earliest and most common food allergies. For this reason cow’s milk allergy can be recognized as one of the first indications of an aberrant inflammatory response in early life. Classically, cow’s milk allergy, as is true for most other allergies as well, is primarily associated with abnormal humoral immune responses, that is, elevation of specific immunoglobulin E levels. There is growing evidence indicating that cellular components of both innate and adaptive immunity play significant roles during the pathogenesis of cow’s milk allergy. This is true for the initiation of the allergic phenotype (stimulation and skewing towards sensitization), development and outgrowth of the allergic disease. This review discusses findings pertaining to roles of cellular immunity in allergic inflammation, and tolerance induction against cow’s milk proteins. In addition, a possible interaction between immune mechanisms underlying cow’s milk allergy and other types of inflammation (infections and noncommunicable diseases) is discussed.

scholarly journals The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy

2021 ◽  
Vol 49 (3) ◽  
pp. 30-41
Author(s):  
Maria Popielarz ◽  
Aneta Krogulska
Keyword(s):  
Milk Proteins ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Recombinant Allergens ◽  
Allergic Reactions ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Ige Mediated

Cow’s milk allergy (CMA) is an increasingly common problem among children and adults that requires the use of appropriate diagnostics to eliminate allergic reactions and prevent unnec-essary dietary regimes. The current diagnostics methods are imperfect hence new, more effective methods are still being sought. Component-resolved diagnostics (CRD) is one of them. CRD assesses sensitivity to individual allergen molecules using purified native or recombinant allergens. The present paper reviews the role of CRD in diagnosing CMA, as well as the benefits and limitations of its use, especially in predicting allergy development or acquiring immunotolerance. It examines the possibility of replacing the current gold diagnostic standard with component tests directed against specific milk proteins. In addition, CRD could be helpful in the evaluation of prognosis. However, CRD allows for improvement in clinical management, particularly of polysensitized subjects, there is still no cogent evidence that it offers more efficient CMA diagnostics than existing tests.

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