scholarly journals Indirect enzyme-linked immunosorbent assay for measurement of human immunoglobulins E and G to purified cow's milk proteins: application in diagnosis of cow's milk allergy.

1987 ◽  
Vol 25 (11) ◽  
pp. 2114-2119 ◽  
Author(s):  
D E Campbell ◽  
J Ngamphaiboon ◽  
M M Clark ◽  
M C Harris ◽  
G B Kolski ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Milk Proteins ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Enzyme Linked Immunosorbent Assay ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Human Immunoglobulins ◽  
Cow’S Milk Proteins

scholarly journals Role of Cellular Immunity in Cow’s Milk Allergy: Pathogenesis, Tolerance Induction, and Beyond

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Juandy Jo ◽  
Johan Garssen ◽  
Leon Knippels ◽  
Elena Sandalova
Keyword(s):  
Cellular Immunity ◽  
Tolerance Induction ◽  
Milk Proteins ◽  
Cow’S Milk Allergy ◽  
Food Allergies ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Cow’S Milk Proteins

Food allergy is an aberrant immune-mediated reaction against harmless food substances, such as cow’s milk proteins. Due to its very early introduction, cow’s milk allergy is one of the earliest and most common food allergies. For this reason cow’s milk allergy can be recognized as one of the first indications of an aberrant inflammatory response in early life. Classically, cow’s milk allergy, as is true for most other allergies as well, is primarily associated with abnormal humoral immune responses, that is, elevation of specific immunoglobulin E levels. There is growing evidence indicating that cellular components of both innate and adaptive immunity play significant roles during the pathogenesis of cow’s milk allergy. This is true for the initiation of the allergic phenotype (stimulation and skewing towards sensitization), development and outgrowth of the allergic disease. This review discusses findings pertaining to roles of cellular immunity in allergic inflammation, and tolerance induction against cow’s milk proteins. In addition, a possible interaction between immune mechanisms underlying cow’s milk allergy and other types of inflammation (infections and noncommunicable diseases) is discussed.

Allergy

PEDIATRICS ◽  
1991 ◽  
Vol 87 (6) ◽  
pp. 985-992
Keyword(s):  
Solid Phase ◽  
Milk Proteins ◽  
Subsequent Development ◽  
Specific Ige ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Β Lactoglobulin

Pathophysiology MATERNAL IMMUNE STATUS AGAINST β-LACTOGLOBULIN AND COW'S MILK ALLERGY IN THE INFANT Casmir GJA, Duchateau J, Cuvelier P, Vis HL. Ann Allergy. 1989;63:517-519 Purpose of the Study The reported frequency of cow's milk allergy in children varies between 0.3% and 7.5% (population with earlier weaning has higher incidence). A thorough family history of atopy and cord IgE level at birth have been used to predict infants "at risk." Previous studies have shown that high cord IgE level (exceeding 1 IU/mL) was predictive of subsequent development of atopic disease. The purpose of this study was to follow-up the predictive relationship of maternal IgG-anti-BLG (IgG against β-lactoglobulin which is a major cow's milk antigen) and allergic manifestations in the infant. Study Population: Subject Section Mothers. All women were selected from the obstetric department of St Pierre Hospital in Brussels, Belgium. Infants. 69 infants were chosen who were born to these mothers by vaginal delivery and were fed cow's milk. Methods Clinical Evaluation. Every month during the first 6 months of life, infants were examined clinically for allergic symptoms. Gastrointestinal signs (diarrhea, vomiting, colic), atopic dermatitis, and respiratory problems (asthma, chronic cough, rhinitis) were recorded. Symptomatic children were treated with Alfare (Nestle) containing hydrolysates of cow's milk proteins with minimal allergenicity. Biologic Investigations. IgG-anti-BLG levels in mothers' sera were measured using solid-phase radioimmunoassay method. These levels were expressed in arbitrary units per milliliter. All children were screened for total IgE levels at 5 days of age. Specific IgE anti-cow's milk radioallergosorbent tests (RASTs) were performed in all patients at 1 month of age.

scholarly journals Molecular and epidemiological basis of cow's milk allergy

2011 ◽  
Vol 10 (6) ◽  
pp. 86-92
Author(s):  
M. M. Fedotova ◽  
L. M. Ogorodova ◽  
O. S. Fyodorova ◽  
T. A. Evdokimova
Keyword(s):  
Pediatric Population ◽  
Milk Proteins ◽  
Current Data ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
High Prevalence ◽  
History Of

Allergy to cow's milk is characterized by early onset and high prevalence in pediatric population. The review presents current data on the molecular structure, physicochemical and allergenic properties of the cow's milk proteins. The patterns of the natural history of cow's milk allergy are described. The aspects of the development of tolerance to the proteins of this product are performed.

scholarly journals The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy

2021 ◽  
Vol 49 (3) ◽  
pp. 30-41
Author(s):  
Maria Popielarz ◽  
Aneta Krogulska
Keyword(s):  
Milk Proteins ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Recombinant Allergens ◽  
Allergic Reactions ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Ige Mediated

Cow’s milk allergy (CMA) is an increasingly common problem among children and adults that requires the use of appropriate diagnostics to eliminate allergic reactions and prevent unnec-essary dietary regimes. The current diagnostics methods are imperfect hence new, more effective methods are still being sought. Component-resolved diagnostics (CRD) is one of them. CRD assesses sensitivity to individual allergen molecules using purified native or recombinant allergens. The present paper reviews the role of CRD in diagnosing CMA, as well as the benefits and limitations of its use, especially in predicting allergy development or acquiring immunotolerance. It examines the possibility of replacing the current gold diagnostic standard with component tests directed against specific milk proteins. In addition, CRD could be helpful in the evaluation of prognosis. However, CRD allows for improvement in clinical management, particularly of polysensitized subjects, there is still no cogent evidence that it offers more efficient CMA diagnostics than existing tests.

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