Variability of the Tick-Borne Encephalitis Virus Genome in the 5′ Noncoding Region Derived from Ticks Ixodes persulcatus and Ixodes pavlovskyi in Western Siberia

2010 ◽  
Vol 10 (4) ◽  
pp. 365-375 ◽  
Author(s):  
Eugene V. Chausov ◽  
Vladimir A. Ternovoi ◽  
Elena V. Protopopova ◽  
Julia V. Kononova ◽  
Svetlana N. Konovalova ◽  
...  
Keyword(s):  
Western Siberia ◽  
Virus Genome ◽  
Encephalitis Virus ◽  
Noncoding Region ◽  
Ixodes Persulcatus ◽  
Tick Borne Encephalitis ◽  
Ixodes Pavlovskyi ◽  
Tick Borne Encephalitis Virus

scholarly journals Comparative analysis of the tick-borne encephalitis virus (TBEV) infection of unfed adult ixodid ticks Ixodes pavlovsky Pomerantsev 1946 and Ixodes persulcatus Schulze in the area of sympatria of their natural habitats

2015 ◽  
Vol 20 (1) ◽  
pp. 20-26
Author(s):  
G. S Chicherina ◽  
O. V Morozova ◽  
V. V Panov ◽  
V. N Romanenko ◽  
S. A Bakhvalov ◽  
...  
Keyword(s):  
Encephalitis Virus ◽  
Ixodid Ticks ◽  
Ixodes Persulcatus ◽  
Anthropogenic Pressure ◽  
Laboratory Mice ◽  
Natural Habitats ◽  
Tick Borne Encephalitis ◽  
Ixodes Pavlovskyi ◽  
Tick Borne Encephalitis Virus ◽  
Tbev Infection

With the use of the ELISA method to detect an antigen, reverse transcription with quantitative real-time PCR with subtype-specific fluorescent probes, phylogenetic analysis of E and NS1 gene nucleotide sequences, bioassays with suckling mice, hemagglutination and neuroinvasiveness tests there was made a comparison of the tick-borne encephalitis virus (TBEV) infection of ixodid ticks Ixodes persulcatus P.Schulze and Ixodes pavlovskyi Pomerantsev 1946 in the area of sympatria of their natural habitats in the Novosibirsk region during growth period of their populations with the replacement ofprevailing species of monodominant type of the ixodid population structure. The ratio of 2 tick species didn’t depend on biotopes ofpine or birch forest but rather on the distance from the Novosibirsk Scientific Center: the lower anthropogenic pressure the smaller I.pavlovskyi proportion. The TBEV rate (including both pathogenic and apathogenic for laboratory mice virus), spectra of the TBEV3 main genetic types, neurovirulence and hemagglutination activity were similarfor both I.persulcatus and I.pavlovskyi. However, the proportion ofpathogenic for laboratory mice virus and the TBEV Far Eastern subtype, as well as viral loads of Siberian and European types for the TBEV from I.pavlovskyi were significantly higher than those from I.persulcatus.

Genetic Variability of Tick-Borne Encephalitis Virus Genome 5'-UTR from Northern Eurasia

2021 ◽  
Vol 55 (3) ◽  
pp. 372-380
Author(s):  
E. P. Ponomareva ◽  
V. A. Ternovoi ◽  
T. P. Mikryukova ◽  
E. V. Protopopova ◽  
N. L. Tupota ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Virus Genome ◽  
Encephalitis Virus ◽  
Northern Eurasia ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

Surveillance of tick-borne encephalitis virus in wild birds and ticks in Tomsk city and its suburbs (Western Siberia)

2014 ◽  
Vol 5 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Tamara P. Mikryukova ◽  
Nina S. Moskvitina ◽  
Yulia V. Kononova ◽  
Igor G. Korobitsyn ◽  
Mikhail Y. Kartashov ◽  
...  
Keyword(s):  
Western Siberia ◽  
Wild Birds ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

Tick-Borne Encephalitis Virus Diversity in Ixodid Ticks and Small Mammals in South-Western Siberia, Russia

2016 ◽  
Vol 16 (8) ◽  
pp. 541-549 ◽  
Author(s):  
Valentina N. Bakhvalova ◽  
Galina S. Chicherina ◽  
Olga F. Potapova ◽  
Victor V. Panov ◽  
Victor V. Glupov ◽  
...  
Keyword(s):  
Small Mammals ◽  
Western Siberia ◽  
Encephalitis Virus ◽  
Ixodid Ticks ◽  
Virus Diversity ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks

2017 ◽  
Vol 62 (1) ◽  
pp. 30-35 ◽  
Author(s):  
N. M. Pukhovskaya ◽  
O. V. Morozova ◽  
N. B. Belozerova ◽  
S. V. Bakhmetyeva ◽  
N. P. Vysochina ◽  
...  
Keyword(s):  
Vaccine Strain ◽  
Far East ◽  
Encephalitis Virus ◽  
Ixodes Persulcatus ◽  
Aedes Vexans ◽  
Tick Borne Encephalitis ◽  
Tbev Strain ◽  
Natural Foci ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5’- and 3’-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5’- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.

New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia

2017 ◽  
Vol 56 ◽  
pp. 36-43 ◽  
Author(s):  
Sergey E. Tkachev ◽  
Galina S. Chicherina ◽  
Irina Golovljova ◽  
Polina S. Belokopytova ◽  
Artem Yu. Tikunov ◽  
...  
Keyword(s):  
Western Siberia ◽  
Encephalitis Virus ◽  
Genetic Lineage ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

scholarly journals Tick-borne encephalitis virus – a review of an emerging zoonosis

2009 ◽  
Vol 90 (8) ◽  
pp. 1781-1794 ◽  
Author(s):  
K. L. Mansfield ◽  
N. Johnson ◽  
L. P. Phipps ◽  
J. R. Stephenson ◽  
A. R. Fooks ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Northern China ◽  
Encephalitis Virus ◽  
Ixodid Ticks ◽  
Ixodes Persulcatus ◽  
Tick Borne Encephalitis ◽  
Far Eastern Russia ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

During the last 30 years, there has been a continued increase in human cases of tick-borne encephalitis (TBE) in Europe, a disease caused by tick-borne encephalitis virus (TBEV). TBEV is endemic in an area ranging from northern China and Japan, through far-eastern Russia to Europe, and is maintained in cycles involving Ixodid ticks (Ixodes ricinus and Ixodes persulcatus) and wild vertebrate hosts. The virus causes a potentially fatal neurological infection, with thousands of cases reported annually throughout Europe. TBE has a significant mortality rate depending upon the strain of virus or may cause long-term neurological/neuropsychiatric sequelae in people affected. In this review, we comprehensively reviewed TBEV, its epidemiology and pathogenesis, the clinical manifestations of TBE, along with vaccination and prevention. We also discuss the factors which may have influenced an apparent increase in the number of reported human cases each year, despite the availability of effective vaccines.

scholarly journals Tick-borne encephalitis virus genome

FEBS Letters ◽  
1986 ◽  
Vol 200 (2) ◽  
pp. 317-321 ◽  
Author(s):  
A.G. Pletnev ◽  
V.F. Yamshchikov ◽  
V.M. Blinov
Keyword(s):  
Virus Genome ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus
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