Creatine kinase and myofibrillar proteins in hereditary muscular dystrophy and vitamin E deficiency

1974 ◽  
Vol 27 (10) ◽  
pp. 1117-1129 ◽  
Author(s):  
Robert Eugene Olson
Keyword(s):  
Creatine Kinase ◽  
Vitamin E ◽  
Muscular Dystrophy ◽  
Myofibrillar Proteins ◽  
Vitamin E Deficiency

Production of Vitamin-E Deficiency and Muscular Dystrophy in Pigs

1961 ◽  
Vol 2 (1) ◽  
pp. 67-72 ◽  
Author(s):  
N. Lannek ◽  
P. Lindberg ◽  
G. Nilsson ◽  
G. Nordström ◽  
K. Orstadius
Keyword(s):  
Vitamin E ◽  
Muscular Dystrophy ◽  
Vitamin E Deficiency

Concentrations of K and Na in Skeletal Muscle of Mice With a Hereditary Myopathy (Dystrophia Muscularis)

1958 ◽  
Vol 193 (3) ◽  
pp. 530-533 ◽  
Author(s):  
Nome Baker ◽  
William H. Blahd ◽  
P. Hart
Keyword(s):  
Skeletal Muscle ◽  
Vitamin E ◽  
Muscular Dystrophy ◽  
Extracellular Space ◽  
Partial Replacement ◽  
Vitamin E Deficiency ◽  
Normal Value ◽  
Hereditary Myopathy ◽  
The Mean ◽  
Dystrophic Mice

Exchangeable body potassium (Ke), muscle potassium and muscle sodium concentrations have been measured in hereditarily dystrophic mice and in their normal littermates. Both Ke and K39/gm muscle were depressed in the dystrophics approximately 20% below the mean normal value; however, the concentration of Na23/gm muscle was higher by 50%, on the average, in the dystrophic tissue. The data suggest a partial replacement of intracellular by extracellular space in the dystrophic mice. Thus, this form of hereditary muscular dystrophy is qualitatively similar, with regard to K and Na concentrations, to human muscular dystrophy, vitamin E deficiency in rabbits, nutritional dystrophy in calves, and denervation in puppies.

scholarly journals Some Effects of Prolonged Vitamin E Deficiency in The Rat

1939 ◽  
Vol 39 (6) ◽  
pp. 643-652 ◽  
Author(s):  
Archer John Porter Martin ◽  
Thomas Moore
Keyword(s):  
Vitamin E ◽  
Muscular Dystrophy ◽  
Skeletal Muscles ◽  
Vitamin E Deficiency ◽  
Leg Muscles ◽  
Brown Discoloration ◽  
Recent Developments ◽  
Preliminary Communication ◽  
Convoluted Tubules ◽  
Nutritional Muscular Dystrophy

IN an early preliminary communication we (Martin & Moore, 1936) reported that in rats maintained for prolonged periods on diets deficient in vitamin E a brown discoloration of the uterus occurred. Degeneration of the convoluted tubules of the kidneys was also found. In a more recent paper we (Martin & Moore, 1938) described a less intense discoloration in the skeletal muscles, which was localized in distribution. The muscles of the hindlegs, which displayed the paresis described by Ringsted (1935), were always noticeably discoloured. In both the uterine and leg muscles discoloration was found to be associated with muscular degeneration. The similarity of the condition in the leg muscles to the nutritional muscular dystrophy first reported by Goettsch & Pappenheimer (1931) in guinea-pigs was noted. The purpose of this communication is to give a detailed account of this work, including its most recent developments (Moore, 1939).

The Pathology of Vitamin E Deficiency in the Chick

1966 ◽  
Vol 3 (3) ◽  
pp. 208-225 ◽  
Author(s):  
Norman F. Cheville
Keyword(s):  
Acid Phosphatase ◽  
Vitamin E ◽  
Muscular Dystrophy ◽  
Phosphatase Activity ◽  
Acid Phosphatase Activity ◽  
Dietary Lipid ◽  
Vitamin E Deficiency ◽  
Exudative Diathesis ◽  
Torula Yeast ◽  
Tissue Changes

Syndromes of encephalomalacia, exudative diathesis and muscular dystrophy were produced in day-old chicks placed on a torula yeast base diet deficient in vitamin E. Changes in the percentage of dietary lipid were responsible for variation in the disease processes. Chicks receiving 3-9% lipid had vascular alterations which determined, in most cases, the severity of the resulting tissue changes. Encephalomalacia occurred only in chicks on 9% dietary lipid. Muscular lesions were seen in all chicks and were thought to be due to damage to the mitochondria. Acid phosphatase activity was not directly associated with degeneration of muscle.

scholarly journals VITAMIN E DEFICIENCY IN THE MONKEY

1957 ◽  
Vol 105 (5) ◽  
pp. 395-402 ◽  
Author(s):  
James S. Dinning ◽  
Paul L. Day
Keyword(s):  
Amino Acids ◽  
Vitamin E ◽  
Muscular Dystrophy ◽  
Free Amino Acids ◽  
Rhesus Monkeys ◽  
Free Amino ◽  
Vitamin E Deficiency

Eight young rhesus monkeys were fed a purified diet devoid of vitamin E. After from 6 to 13 months of feeding, all the animals developed signs of vitamin E deficiency. The signs of vitamin E deficiency in the monkey include muscular dystrophy, elevated excretion of creatine, allantoin, and free amino acids and decreased excretion of creatinine. The vitamin E-deficient monkeys all developed anemia and granulocytosis. Anemia was the first sign of vitamin E deficiency which was observed. All of these signs of vitamin E deficiency were reversed by treatment with α-tocopherol.

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