Adenoviral Infection in Suckling Arabian Foals

A fatal adenoviral infection was recently recognized in suckling Arabian foals from Colorado, Kansas, Nebraska, and Wyoming. Affected foals had clinical signs of pneumonia accompanied by fever, absolute lymphopenia, and neutropenia. Characteristic lesions with typical adenoviral inclusions occurred in respiratory epithelium of all cases. Other tissues with significant changes and inclusion bodies were conjuctiva, urinary mucosa, pancreas, and salivary glands. Lymphoid follicular atrophy and hepatic degeneration were frequent but were not accompanied by inclusions.

A Canine Venereal Tumor with Metastasis to the Brain

A naturally occurring malignant canine venereal tumor in the vagina of a mature Collie dog did not regress following surgical intervention. The tumor progressed fatally over a period of 5 weeks and metastasized to the inguinal and iliac lymph nodes, spleen, eye, and brain. It had a modal number of 60 chromosomes of which 17 were metacentric.

Renal Nosematosis in Young Rubbits

The kidneys of 100 of 2,338 rabbits (4.3%) slaughtered for human consumption had focal cortical depressions. Histologically, the lesions in these kidneys consisted of focal granulomatous nephritis to chronic interstitial nephritis with scarring. Nosema cuniculi was demonstrated microscopically in 35 (35%) of the grossly affected kidneys. The number of organisms decreased as the lesions became older.

Origin of the Aorta and Pulmonary Trunk from the Right Ventricle in a Horse

A malformation of the heart and great vessels, in which the aorta and the pulmonary trunk originated from the right ventricle, has been reported in a 1 1/2 year-old horse. It is suggested that the oxygenated blood from the left ventricle was ejected through a large septal defect into the right ventricle where partial mixture of the blood took place. The function of the right ventricle was to pump the blood into the aorta and the pulmonary trunk. The muscular ridge, which was interposed between the aorta and the pulmonary trunk, might have directed a portion of the predominately oxygenated blood into the aorta and a portion of the predominately venous blood into the pulmonary trunk.

Hepatic Cholesterol-Lipid Anomalies Induced by Aflatoxin

A diet of 60% peanut meal (W.H.O/F.A.O/U.N.I.C.E.F) was fed either toxin free or adulterated with aflatoxin at the rate of 0.948 μg B1 and 0.630 μ G1 to ducklings for a 10-day period. The ingestion of aflatoxin increased from 14.99 in 16.70 μg per day per duckling with outward signs of repression of growth and reduced feed efficiency as measured by changes in weight. Compared with those ducklings fed a toxin-free food, aflatoxin resulted in an increase of the liver in size from 3.8 to 4.4%; total hepatic lipids of the intoxicated ducklings decreased from 23.0% to 14.0% while cholesterol remained above 22% with marked contrast in crystalline form and cellular distribution. Normal changes in triglycerides were reversed with oleic and linoleic acids increased while palmitic and stearic acids were decreased. Levels of linoleic acid were significantly higher within ducklings fed the aflatoxin diet.

Pathology of Locoweed (Astragalus lentiginosus) Poisoning in Sheep; Sequential Development of Cyloplasmie Vacuolation in Tissues

Sheep experimentally poisoned by ingestion of Astragalus letiginosus developed cytoplasmic vacuolation of the proximal tubular epithelia within 4 days after beginning of the experiment. Neuronal vacuolation occurred by day 8 and had progressed to neuronolysis by day 16.

Phototoxic Syndrome Induced in Mice by Rice Cultures of Penicillium viridicatum and Exposure to Sunlight

A hepatogenous phototoxic syndrome was induced in mice by the feeding of rice cultures of P. viridicaunn and exposure to sunlight. The pathologic changes in the livers and skin were similar to those described in facial eczema of sheep in New Zealand and Bermuda-grass and alfalfa-hay toxicoses in the United States of America. The phototoxic syndrome was characterized by congestion of the pinna followed by erythema and edema of the cars, muzzle, paws, and tail, occasionally accompanied by alopecia. In some mice the tip of the ears became gangrenous and sloughed. Keratitis and keratoeonus leading to blindness occurred. The incidence of phototoxic reactions was higher in older mice and in those subjected to delayed exposure to sunlight. Aspermatogenesis and formation of syncytial spermatids occurred in some mice.