Usefulness of Certain Red Blood Cell Indices in Diagnosing and Differentiating Thalassemia Trait From Iron-Deficiency Anemia

1999 ◽  
Vol 111 (5) ◽  
pp. 676-682 ◽  
Author(s):  
Mohamed M. Eldibany ◽  
Kameel F. Totonchi ◽  
Ninos J. Joseph ◽  
Douglas Rhone
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Red Blood Cell Indices ◽  
Thalassemia Trait

Diagnostic Utility of Red Blood Cell Indices-Derived Formulas in Discriminating Beta-Thalassemia Trait from Iron Deficiency Anemia

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Maggie Ibrahim Shoukry ◽  
Amany Ahmed Osman ◽  
Deena Samir Eissa
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Diagnostic Utility ◽  
Diagnostic Efficacy ◽  
Confirmatory Tests ◽  
Red Blood Cell Indices ◽  
Thalassemia Trait

Abstract Background The two most frequently encountered microcytic hypochromic anemias are iron deficiency anemia (IDA) and β-thalassemia trait (β-TT) which need relatively expensive laboratory tests to be differentiated. Objectives This study aims at evaluating the diagnostic utility of different discrimination formulas derived from red blood cell indices from complete blood count in the differentiation of β-TT from IDA. Subjects and Methods This study was conducted on 140 subjects; 40 healthy individuals and 100 patients (60 IDA and 40 β-TT) recruited from outpatient clinics of Ain Shams University Hospitals. They were 45 males and 95 females (M: F 1:2.1), their ages ranged from 19 to 63 years. Patients were subjected to measurement of CBC, iron profile, Hb electrophoresis and HPLC and calculation of RBC indices- derived formulas. Results Comparative studies of different formulas among the studied group shows that England and Fraser (E & F), MDHL, MCHD, MCI and Zaghloul 2 can significantly differentiate between β-TT patients and IDA patients (P was 0.009, 0.008, 0, 0.001 and 0.050 respectively). Evaluation of diagnostic performance (efficacy) of the studied RBCs formulas showed that Zaghloul 2 is the best index in discriminating β-TT from IDA at cut off 66.61 with specificity (97.5%), sensitivity (76.7%) and diagnostic efficacy (85%). This was followed by MCI at cut off 22.73 with specificity (57.5%), sensitivity (85.0%) and diagnostic efficacy (74. %). Then they are followed by MDHL at cut off 1.487 with specificity (50.0%), sensitivity (86.7%) and diagnostic efficacy (72.0), then England and Fraser with cut off 8.9 with specificity (50.0%), sensitivity (80.0%) and diagnostic efficacy (68.0%), and lastly MCHD with cut off 0.296 with specificity (72.5%), sensitivity (61.7%) and diagnostic efficacy (66.0%). Values above these cut off levels indicate β-TT whereas values below these levels indicate IDA except for E&F formula where <8.9 cut off indicate β-TT and >8.9 indicate IDA. Conclusion Zaghloul 2 formula showed the highest efficacy in the differentiation of β-TT from IDA (85%) followed by MCI (74%) and MDHL (72%) then England and Fraser (68%) and lastly MCHD (66%). They can be used for screening in big population, being simple and inexpensive, and then followed by the usual confirmatory tests. Their real use comes in rural areas and primary care facilities where only red blood cell indices are handy. They can be calculated and the cases can be referred to secondary health care to take the confirmatory tests for diagnosis.

Usefulness of red blood cell flags in diagnosing and differentiating thalassemia trait from iron-deficiency anemia

Hematology ◽  
2008 ◽  
Vol 13 (4) ◽  
pp. 253-256 ◽  
Author(s):  
J. Eivazi-Ziaei ◽  
S. Dastgiri ◽  
S. Pourebrahim ◽  
R. Soltanpour
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Thalassemia Trait

scholarly journals Diagnostic value of reticulocyte hemoglobin equivalent to confirm iron deficiency in full-term infants

2020 ◽  
Vol 65 (3) ◽  
pp. 44-52
Author(s):  
E. A. Balashova ◽  
L. I. Mazur ◽  
N. P. Persteneva
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Diagnostic Value ◽  
Full Term ◽  
Deficiency Anemia ◽  
Laboratory Examination ◽  
Term Infants ◽  
Red Blood Cell Indices

Diagnostics of Iron deficiency anemia (IDA) in outpatient pediatric practice is often based on decreased hemoglobin level. Latent iron deficiency diagnostic is not a part of current routine practice.Objective. To study the diagnostic value of red blood cell indices and reticulocyte hemoglobin equivalent in diagnostics of iron deficiency in full-term infants.Children characteristics and research methods. A prospective cohort study of healthy full-term children aged from 6 to 12 months at the children hospitals of Samara and Tolyatti. The laboratory examination included a general blood test to determine the concentration of hemoglobin, the number of red blood cells, red blood cell indices, and reticulocyte hemoglobin equivalent (Ret-He); to determine serum ferritin and C-reactive protein. The AUC (area under the curve) was used to determine the diagnostic value of quantitative indicators. The children with anemia without iron deficiency and children who received iron supplements within 1 month prior to laboratory examination were excluded from the analysis.Results. The study involved 207 children. When diagnosing iron deficiency in children, the highest AUC was found in Ret-He: 0.747 [0.679; 0.816] in 6-months-old children and 0.790 [0.708; 0.871] in 1-year-old children. The Ret-He diagnostic value was higher in children with iron deficiency: AUC 0.826 [0.754; 0.898] in 6- months-old children and 0.865 [0.809; 0.920] in 1-year-old children.Conclusion. Ret-He is a better predictor of iron deficiency in children under 1 year as compared to the red blood cell indices. The diagnostic value of red blood cell indices and Ret-He is higher in case of iron deficiency anemia than in case of iron deficiency conditions.

Proposal of a score combining red blood cell indices for early differentiation of beta‐thalassemia minor from iron deficiency anemia

Hematology ◽  
2011 ◽  
Vol 16 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Alexandre Janel ◽  
Laurence Roszyk ◽  
Chantal Rapatel ◽  
Gabrielle Mareynat ◽  
Marc G Berger ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Beta Thalassemia ◽  
Early Differentiation ◽  
Thalassemia Minor ◽  
Red Blood Cell Indices

P082 Usefulness of red blood cell flags in diagnosing and differentiating thalassemia trait from iron-deficiency anemia

Blood Reviews ◽  
2007 ◽  
Vol 21 ◽  
pp. S112
Author(s):  
J. Eivazi-Ziaei ◽  
S. Dastgiri ◽  
S. Ebrahimpour ◽  
R. Soltanpour ◽  
A. Mahmoudpour
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Thalassemia Trait
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