Red blood cell count and rapid discrimination between thalassemia trait and iron deficiency anemia

2004 ◽  
Vol 46 (3) ◽  
pp. 384-384 ◽  
Author(s):  
Deniz Aslan
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Cell Count ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Blood Cell Count ◽  
Red Blood Cell Count ◽  
Thalassemia Trait ◽  
Rapid Discrimination

Usefulness of red blood cell flags in diagnosing and differentiating thalassemia trait from iron-deficiency anemia

Hematology ◽  
2008 ◽  
Vol 13 (4) ◽  
pp. 253-256 ◽  
Author(s):  
J. Eivazi-Ziaei ◽  
S. Dastgiri ◽  
S. Pourebrahim ◽  
R. Soltanpour
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Thalassemia Trait

Diagnostic Utility of Red Blood Cell Indices-Derived Formulas in Discriminating Beta-Thalassemia Trait from Iron Deficiency Anemia

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Maggie Ibrahim Shoukry ◽  
Amany Ahmed Osman ◽  
Deena Samir Eissa
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Diagnostic Utility ◽  
Diagnostic Efficacy ◽  
Confirmatory Tests ◽  
Red Blood Cell Indices ◽  
Thalassemia Trait

Abstract Background The two most frequently encountered microcytic hypochromic anemias are iron deficiency anemia (IDA) and β-thalassemia trait (β-TT) which need relatively expensive laboratory tests to be differentiated. Objectives This study aims at evaluating the diagnostic utility of different discrimination formulas derived from red blood cell indices from complete blood count in the differentiation of β-TT from IDA. Subjects and Methods This study was conducted on 140 subjects; 40 healthy individuals and 100 patients (60 IDA and 40 β-TT) recruited from outpatient clinics of Ain Shams University Hospitals. They were 45 males and 95 females (M: F 1:2.1), their ages ranged from 19 to 63 years. Patients were subjected to measurement of CBC, iron profile, Hb electrophoresis and HPLC and calculation of RBC indices- derived formulas. Results Comparative studies of different formulas among the studied group shows that England and Fraser (E & F), MDHL, MCHD, MCI and Zaghloul 2 can significantly differentiate between β-TT patients and IDA patients (P was 0.009, 0.008, 0, 0.001 and 0.050 respectively). Evaluation of diagnostic performance (efficacy) of the studied RBCs formulas showed that Zaghloul 2 is the best index in discriminating β-TT from IDA at cut off 66.61 with specificity (97.5%), sensitivity (76.7%) and diagnostic efficacy (85%). This was followed by MCI at cut off 22.73 with specificity (57.5%), sensitivity (85.0%) and diagnostic efficacy (74. %). Then they are followed by MDHL at cut off 1.487 with specificity (50.0%), sensitivity (86.7%) and diagnostic efficacy (72.0), then England and Fraser with cut off 8.9 with specificity (50.0%), sensitivity (80.0%) and diagnostic efficacy (68.0%), and lastly MCHD with cut off 0.296 with specificity (72.5%), sensitivity (61.7%) and diagnostic efficacy (66.0%). Values above these cut off levels indicate β-TT whereas values below these levels indicate IDA except for E&F formula where <8.9 cut off indicate β-TT and >8.9 indicate IDA. Conclusion Zaghloul 2 formula showed the highest efficacy in the differentiation of β-TT from IDA (85%) followed by MCI (74%) and MDHL (72%) then England and Fraser (68%) and lastly MCHD (66%). They can be used for screening in big population, being simple and inexpensive, and then followed by the usual confirmatory tests. Their real use comes in rural areas and primary care facilities where only red blood cell indices are handy. They can be calculated and the cases can be referred to secondary health care to take the confirmatory tests for diagnosis.

P082 Usefulness of red blood cell flags in diagnosing and differentiating thalassemia trait from iron-deficiency anemia

Blood Reviews ◽  
2007 ◽  
Vol 21 ◽  
pp. S112
Author(s):  
J. Eivazi-Ziaei ◽  
S. Dastgiri ◽  
S. Ebrahimpour ◽  
R. Soltanpour ◽  
A. Mahmoudpour
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Thalassemia Trait

scholarly journals Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count: Meta-analysis 1980–2018

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alejandro Gil-Betacur ◽  
Carmen Yulieth Mantilla-Gutiérrez ◽  
Jaiberth Antonio Cardona-Arias
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Erythrocyte Count ◽  
Blood Cell Count ◽  
Selection Processes ◽  
Negative Effect ◽  
Red Blood Cell Count ◽  
The Mean

AbstractThe effects of platelet donation by apheresis on different parameters of the erythrogram are still unclear. The objective was to meta-analyze the effect of plateletpheresis on hematocrit, hemoglobin, and erythrocyte count, with a systematic review with random effects meta-analysis of the mean difference. The PRISMA guidelines were considered, as well as 133 search strategies on four different databases. Reproducibility was guaranteed and methodological quality was evaluated. Heterogeneity was evaluated with Galbraith and DerSimonian-Laird’s, publication bias with a funnel plot and a Begg’s test, sensitivity analysis and a cumulative meta-analysis were also conducted. Eighteen (18) articles were included, 17 evaluated the effects on hematocrit in 2,564 donors; 13 on hemoglobin in 1,640 donors; and 4 on red blood cell count in 243 donors. A decrease of 2.26% (CI95% = 2.11–2.41) was observed in hematocrit, of 0.80 g/dL (CI95% = 0.75–0.86) in hemoglobin and −0.21 × 1012/L (CI95% = −0.13; −0.29) in red blood cell count. Plateletpheresis has a negative effect on the erythrogram parameters, explained by blood loss in the kits used for the procedure and cell lysis. Such evidence is relevant to secure the efficiency and safety of the procedure, improve selection processes or determine the number of donations that can be performed without affecting donors’ health.

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