The Value of the Bone-marrow Biopsy in the Diagnosis of Hairy Cell Leukemia

1978 ◽  
Vol 70 (6) ◽  
pp. 876-884 ◽  
Author(s):  
Jerome S. Burke
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Hairy Cell Leukemia ◽  
Hairy Cell ◽  
Cell Leukemia

scholarly journals A Case Report of Hairy Cell Leukemia Presenting Concomitantly with Sweet Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Mohammad Alkayem ◽  
Waina Cheng
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Skin Biopsy ◽  
Bone Marrow Biopsy ◽  
Hairy Cell Leukemia ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Sweet Syndrome ◽  
Purine Analogs

Hairy cell leukemia and Sweet syndrome are both uncommon hematological diagnoses. We present a patient who was admitted with fevers, pancytopenia, pneumonia, and rash. Diagnostic bone marrow biopsy demonstrates Hairy cell Leukemia and skin biopsy demonstrates neutrophils infiltration consistent with Sweet syndrome. The patient was treated with purine analogs with resolution of the cytopenias, infection, and rash.

Efficacy of Annexin A1 Immunostaining in Bone Marrow for the Diagnosis of Hairy Cell Leukemia

2019 ◽  
Vol 9 (4) ◽  
pp. 236
Author(s):  
Chang-Hun Park ◽  
Hyun-Young Kim ◽  
Sang-Yong Shin ◽  
Hee-Jin Kim ◽  
Chul Won Jung ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hairy Cell Leukemia ◽  
Annexin A1 ◽  
Hairy Cell ◽  
Cell Leukemia

Phospho-ERKTHR202/Tyr214 Is Overexpressed in Hairy Cell Leukemia and Is a Useful Diagnostic Marker in Bone Marrow Trephine Sections

2013 ◽  
Vol 37 (2) ◽  
pp. 305-308 ◽  
Author(s):  
Douglas W. Warden ◽  
Sarah Ondrejka ◽  
Jeffrey Lin ◽  
Lisa Durkin ◽  
Juraj Bodo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hairy Cell Leukemia ◽  
Diagnostic Marker ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Trephine

A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies–A Tissue Microarray Study

2014 ◽  
Vol 21 (1) ◽  
pp. 203-211 ◽  
Author(s):  
Judit Tóth-Lipták ◽  
Klára Piukovics ◽  
Zita Borbényi ◽  
Judit Demeter ◽  
Enikő Bagdi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tissue Microarray ◽  
Hairy Cell Leukemia ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Trephine ◽  
Microarray Study ◽  
Marker Analysis

scholarly journals Treatment of hairy cell leukemia with recombinant alpha 2 interferon

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 644-648 ◽  
Author(s):  
MJ Ratain ◽  
HM Golomb ◽  
JW Vardiman ◽  
EE Vokes ◽  
RH Jacobs ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Intracerebral Hemorrhage ◽  
Hairy Cell Leukemia ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Biopsies ◽  
Subcutaneous Injections

Abstract Nine patients with progressive hairy cell leukemia were treated with subcutaneous injections of recombinant alpha 2 interferon (2 to 10 X 10(6) U/m2) three times weekly. Eight patients completed at least eight weeks of treatment and were evaluable; one patient with refractory thrombocytopenia died of an intracerebral hemorrhage after two doses of interferon. Seven of eight patients responded, with responses occurring as early as two weeks. Four patients also had resolution of their monocytopenia. No complete responses were seen with up to 30 weeks of treatment. Bone marrow biopsies demonstrated improvement in all eight patients. No unforeseen toxicity occurred, but most patients had transient myelosuppression during the first few weeks of treatment. Recombinant alpha 2 interferon is effective in the treatment of hairy cell leukemia, with acceptable toxicity.

scholarly journals Low-dose deoxycoformycin in the treatment of hairy cell leukemia

Blood ◽  
1986 ◽  
Vol 68 (5) ◽  
pp. 1119-1122 ◽  
Author(s):  
EH Kraut ◽  
BA Bouroncle ◽  
MR Grever
Keyword(s):  
Bone Marrow ◽  
Complete Remission ◽  
Hairy Cell Leukemia ◽  
Low Dose ◽  
Intravenous Bolus ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Normal Peripheral Blood ◽  
Hairy Cells ◽  
Reversible Reduction

Abstract Ten patients with progressive hairy cell leukemia were treated with 2′deoxycoformycin (dCF) by intravenous bolus (4 mg/m2) given every other week. All ten patients are evaluable for response and nine of the ten patients have achieved a complete remission. In addition to clearing of hairy cells from the bone marrow, eight patients had resolution of their monocytopenia. Seven of the nine patients remain in unmaintained remission with a median duration of 6.2 months. Two patients have had relapse in the bone marrow alone and continue to have normal peripheral blood counts. They are being followed without treatment. Toxicity was minimal at this low dose with one patient having a mild reversible reduction in creatinine clearance. Four other patients had reversible neutropenia. There were no significant infections associated with treatment. Low-dose deoxycoformycin administered intravenously every other week represents an extremely effective treatment for hairy cell leukemia.

scholarly journals Diffuse osteosclerosis in hairy cell leukemia

Blood ◽  
1989 ◽  
Vol 74 (6) ◽  
pp. 2066-2069 ◽  
Author(s):  
LA VanderMolen ◽  
WJ Urba ◽  
DL Longo ◽  
J Lawrence ◽  
H Gralnick ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Interferon Alpha ◽  
Successful Treatment ◽  
Hairy Cell Leukemia ◽  
Malignant Disease ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Biopsies ◽  
Biopsy Needle ◽  
History Of

Abstract We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatment of her hairy cell leukemia with interferon alpha and deoxycoformycin suggesting that the osteosclerosis observed was related to the underlying malignant disease. Possible etiologic mechanisms are discussed.

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