scholarly journals A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies

2012 ◽  
Vol 23 (5) ◽  
pp. 1307-1313 ◽  
Author(s):  
H.-T. Arkenau ◽  
R. Plummer ◽  
L.R. Molife ◽  
D. Olmos ◽  
T.A. Yap ◽  
...  
Keyword(s):  
Phase I ◽  
Small Molecule ◽  
Dose Escalation ◽  
Small Molecule Inhibitor ◽  
Dose Escalation Study ◽  
Aurora Kinases ◽  
Molecule Inhibitor ◽  
Solid Malignancies

scholarly journals A Phase I and Pharmacodynamic Study of AT9283, a Small-Molecule Inhibitor of Aurora Kinases in Patients With Relapsed/Refractory Leukemia or Myelofibrosis

2014 ◽  
Vol 14 (3) ◽  
pp. 223-230 ◽  
Author(s):  
James Foran ◽  
Farhad Ravandi ◽  
William Wierda ◽  
Guillermo Garcia-Manero ◽  
Srdan Verstovsek ◽  
...  
Keyword(s):  
Phase I ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Aurora Kinases ◽  
Molecule Inhibitor ◽  
Pharmacodynamic Study

scholarly journals Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

2006 ◽  
Vol 5 (7) ◽  
pp. 1764-1773 ◽  
Author(s):  
Steven L. Warner ◽  
Sridevi Bashyam ◽  
Hariprasad Vankayalapati ◽  
David J. Bearss ◽  
Haiyong Han ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Aurora Kinases ◽  
Molecule Inhibitor

9155 Sunitinib combined with pemetrexed and cisplatin in patients with advanced solid malignancies: phase I dose escalation study

2009 ◽  
Vol 7 (2) ◽  
pp. 552
Author(s):  
N. Blais ◽  
D.R. Camidge ◽  
D.J. Jonker ◽  
D. Soulières ◽  
R.C. Doebele ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Dose Escalation Study ◽  
Solid Malignancies

A phase I dose-escalation study of zd0473 combined with paclitaxel in refractory solid malignancies

2001 ◽  
Vol 37 ◽  
pp. S74-S75 ◽  
Author(s):  
U. Gatzemeier ◽  
C. Twelves ◽  
D.A. Anthoney ◽  
G. Pentheroudakis ◽  
G. Groth ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Dose Escalation Study ◽  
Solid Malignancies
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