scholarly journals Risk factors for local and regional recurrence in patients with resected N0–N1 non-small-cell lung cancer, with implications for patient selection for adjuvant radiation therapy

2013 ◽  
Vol 24 (1) ◽  
pp. 67-74 ◽  
Author(s):  
J.L. Lopez Guerra ◽  
D.R. Gomez ◽  
S.H. Lin ◽  
L.B. Levy ◽  
Y. Zhuang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Patient Selection ◽  
Small Cell ◽  
Adjuvant Radiation ◽  
Small Cell Lung ◽  
Adjuvant Radiation Therapy ◽  
Selection For

Adjuvant Radiation Therapy After Complete Resection of Non–Small-Cell Lung Cancer

2002 ◽  
Vol 20 (5) ◽  
pp. 1427-1429
Author(s):  
Eric Vallières ◽  
Mitchell Machtay ◽  
Eli Glatstein ◽  
James A. Bonner
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Complete Resection ◽  
Small Cell ◽  
Adjuvant Radiation ◽  
Small Cell Lung ◽  
Adjuvant Radiation Therapy

Timing of adjuvant radiation therapy and survival outcomes after surgical resection of intracranial non-small cell lung cancer metastases

2019 ◽  
Vol 183 ◽  
pp. 105389
Author(s):  
John P. Sheppard ◽  
Giyarpuram N. Prashant ◽  
Cheng Hao Jacky Chen ◽  
Sophie Peeters ◽  
Carlito Lagman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Surgical Resection ◽  
Small Cell ◽  
Survival Outcomes ◽  
Adjuvant Radiation ◽  
Small Cell Lung ◽  
Adjuvant Radiation Therapy ◽  
Cancer Metastases

scholarly journals SURG-04. Surgical resection of symptomatic brain metastasis in patients with non-small cell lung cancer irrespective from lesion count

2021 ◽  
Vol 3 (Supplement_3) ◽  
pp. iii24-iii24
Author(s):  
Stephanie T Jünger ◽  
David Reinecke ◽  
Anna-Katharina Meißner ◽  
Roland Goldbrunner ◽  
Stefan Grau
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Systemic Treatment ◽  
Small Cell ◽  
Adjuvant Radiation ◽  
Lesion Count ◽  
Small Cell Lung ◽  
Adjuvant Radiation Therapy ◽  
Adjuvant Systemic Treatment

Abstract Background and Purpose Current guidelines primarily suggest the resection in case of a limited number of brain metastases (BM). With an increasing number of local and systemic treatment options this approach needs reconsideration. Therefore, we aimed to evaluate the role of metastectomy in patients with non-small cell lung cancer (NSCLC) treated in a comprehensive setting disregarding lesion count. Patients and Methods In this monocentric retrospective analysis, patients receiving surgery for 1–3 BM with available demographic, clinical, and tumor-associated parameters were included. Prognostic factors for local control (LC) and overall survival (OS) were analyzed by Log rank test and Cox proportional hazards. Results Two-hundred-sixteen patients were included: 129 (59.7%) with single/solitary, 64 (29.6%) with 2–3, and 23 (10.6%) with more than three BM. Resection of the symptomatic BM(s) improved the patients’ Karnofsky performance index (KPI) significantly (p<0.001), enabling adjuvant radiotherapy in 199 (92.1%) and systemic treatment in 119 (55.1%) patients. After a mean radiological follow-up of eight (1–79) months, LC was observed in 83 (38.4%) patients and was not significantly influenced by BM count (p=0.064). After a mean OS after surgery of 12.7 (0–88) months, 120 (55.6%) patients had died. In univariate analysis, BM count showed no impact on OS (p=0.844), while age ≥/< 65 years (p=0.007), pre- and postoperative KPI ≥70 (p=0.002 and p=0.005, respectively), extra-cranial metastases (p=0.004), adjuvant radiation therapy (p<0.001), and adjuvant systemic treatment (p<0.001) did. In regression analysis the presence of extra-cranial metastases (HR 2.30 95%CI 1.53–3.48; p<0.001), adjuvant radiation therapy (HR 0.97 95%CI 0.23–0.86; p=0.016), and adjuvant systemic treatment (HR 0.37 95%CI 0.25–0.55; p<0.001) remained independent factors for survival. Conclusions The indication for resection of symptomatic BM in patients with NSCLC is justified even in case of multiple lesions to alleviate their neurological symptoms and to enable further treatment.

scholarly journals Survival after adjuvant radiation therapy in localized small cell lung cancer treated with complete resection

2019 ◽  
Vol 158 (6) ◽  
pp. 1665-1677.e2 ◽  
Author(s):  
Kathryn E. Engelhardt ◽  
Julia M. Coughlin ◽  
Malcolm M. DeCamp ◽  
Chadrick E. Denlinger ◽  
Shari L. Meyerson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Complete Resection ◽  
Small Cell ◽  
Adjuvant Radiation ◽  
Small Cell Lung ◽  
Adjuvant Radiation Therapy

scholarly journals Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice

2018 ◽  
Vol 14 (23) ◽  
pp. 2415-2431 ◽  
Author(s):  
Raffaele Califano ◽  
Rohit Lal ◽  
Conrad Lewanski ◽  
Marianne C Nicolson ◽  
Christian H Ottensmeier ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Practice ◽  
Small Cell Lung Cancer ◽  
Patient Selection ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Selection For
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