Short-Term Exposure Effects of Endocrine Disrupting Chemicals on the Brain-Pituitary-Gonadal Axis Response of the Fathead Minnow.

The potential for man-made chemicals to mimic or antagonise natural hormones is a controversial issue, but one for which increasing amounts of evidence are being gathered worldwide. The controversy surrounds not so much the matter of whether these chemicals can mimic hormones invitro— this phenomenon has been widely accepted in the scientific world — but more whether, as a result, they can disrupt reproduction in a wildlife situation. It has, nevertheless, been acknowledged that many wildlife populations are exhibiting reproductive and/or developmental abnormalities such as intersex gonads in wild roach populations in the U.K.[1] and various reproductive disorders in alligators in Lake Apopka, Florida[2]. However, the causative agents for many of these effects are difficult to specify, due to the extensive mixtures of chemicals — each of which may act via different pathways — to which wild populations are exposed, together with the wide variability observed even in natural (uncontaminated) habitats. As a result, any information detailing fundamental mechanism of action of the so-called endocrine disrupting chemicals (EDCs) is of use in determining whether or not these chemicals, as they are present in the environment, may in fact be capable of causing some of the effects observed in wildlife over recent years.

Download Full-text

Morphological sex reversal upon short-term exposure to endocrine modulators in juvenile fathead minnow (Pimephales promelas)

Toxicology Letters ◽

10.1016/s0378-4274(02)00070-x ◽

2002 ◽

Vol 131 (1-2) ◽

pp. 51-63 ◽

Cited By ~ 57

Author(s):

Melanie Zerulla ◽

R Länge ◽

T Steger-Hartmann ◽

G Panter ◽

T Hutchinson ◽

...

Keyword(s):

Fathead Minnow ◽

Pimephales Promelas ◽

Sex Reversal ◽

Short Term ◽

Short Term Exposure

Download Full-text

Impacts of the phenylpyrazole insecticide fipronil on larval fish: Time-series gene transcription responses in fathead minnow (Pimephales promelas) following short-term exposure

The Science of The Total Environment ◽

10.1016/j.scitotenv.2012.04.005 ◽

2012 ◽

Vol 426 ◽

pp. 160-165 ◽

Cited By ~ 42

Author(s):

Sebastian Beggel ◽

Inge Werner ◽

Richard E. Connon ◽

Juergen P. Geist

Keyword(s):

Time Series ◽

Gene Transcription ◽

Fathead Minnow ◽

Larval Fish ◽

Pimephales Promelas ◽

Short Term ◽

Short Term Exposure

Download Full-text

Short-term effects of endocrine-disrupting chemicals on the expression of estrogen-responsive genes in male medaka (Oryzias latipes)

Aquatic Toxicology ◽

10.1016/j.aquatox.2004.12.011 ◽

2005 ◽

Vol 72 (3) ◽

pp. 239-249 ◽

Cited By ~ 91

Author(s):

Akemi Yamaguchi ◽

Hiroshi Ishibashi ◽

Shinya Kohra ◽

Koji Arizono ◽

Nobuaki Tominaga

Keyword(s):

Endocrine Disrupting Chemicals ◽

Oryzias Latipes ◽

Short Term ◽

Endocrine Disrupting ◽

Short Term Effects

Download Full-text

A novel framework for interpretation of data from the fish short-term reproduction assay (FSTRA) for the detection of endocrine-disrupting chemicals

Environmental Toxicology and Chemistry ◽

10.1002/etc.2708 ◽

2014 ◽

Vol 33 (11) ◽

pp. 2529-2540 ◽

Cited By ~ 21

Author(s):

Gerald T. Ankley ◽

Kathleen M. Jensen

Keyword(s):

Endocrine Disrupting Chemicals ◽

Short Term ◽

Endocrine Disrupting

Download Full-text

The Immunoreactivity of Calbindin on Cerebellum Cortex and Hippocampus of Mice Brain After One Week Exposure To Radiofrequency Radiation.

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v13i3.17905 ◽

2017 ◽

Vol 13 (3) ◽

pp. 340-344

Author(s):

Bijay Aryal

Keyword(s):

Calcium Homeostasis ◽

Calcium Binding ◽

Behavior Changes ◽

Short Term ◽

Radiofrequency Radiation ◽

Short Term Exposure ◽

Mice Brain ◽

Calcium Permeability ◽

Calbindin D ◽

The Brain

Background & Objectives:Radiofrequency radiation affects the calcium permeability and accordingly this induces pathophysiological changes in the brain and its subsequent output in the brain as tumor genesis, neural degeneration, and cognition or behavior changes. Hence, we investigated the effects of radiofrequency (RF) radiation on calcium binding proteins, reactive gliosis, and tumor genesis in mouse brain. Materials & Methods:Mice were exposed to radiofrequency radiation in the cage chamber with average specific absorption rate (SAR) of 1.6 W/kg and 4.0 W/Kg for one hour per day for five days. For histochemical studies, radiofrequency exposed brains were compared with sham control using calbindin D-28k antibody.Results:The immunoreactivity of calbindin D-28k, a marker for calcium homeostasis was found to increase in dose-response manner in hippocampus and cerebellar cortex.Conclusion:The short-term exposure to 835 MHz RF could induce disruption of calcium homeostasis and resulting neurobehavioral changes or brain tumor.

Download Full-text