A novel framework for interpretation of data from the fish short-term reproduction assay (FSTRA) for the detection of endocrine-disrupting chemicals

AbstractPhytoestrogens have been widely praised for their health-promoting effects, whereas synthetic environmental estrogens are considered a toxicological risk to human health. The aim of this study was therefore to compare in vitro the estrogenic, cytotoxic, and genotoxic profiles of three common estrogen-like endocrine-disrupting chemicals: the phytoestrogens 8-prenylnaringenine (8-PN) and genistein and the synthetic xenoestrogen tartrazine. As assessed by a yeast bioreporter assay and estrogen-dependent proliferative response in human mammary gland adenocarcinoma cell line (MCF-7), 8-PN showed the highest estrogen-like activity of the three compounds, followed by tartrazine and genistein. After 24-h incubation on MCF-7 cells, all three compounds exhibited low cytotoxicity in the lactate dehydrogenase assay and no genotoxicity in the micronucleus assay. These results demonstrate that 8-PN, genistein and tartrazine possess variable estrogenic activity but display little cellular toxicity in short-term tests in vitro. No difference between phytoestrogens and a synthetic xenoestrogen could be established.

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The mosaic effects of endocrine disrupting chemicals mixtures on thyroid hormone levels: experimental study

Endocrine Abstracts ◽

10.1530/endoabs.70.oc8.1 ◽

2020 ◽

Author(s):

Aleksandra Buha ◽

Vesna Milovanovic ◽

Zorica Bulat ◽

Biljana Antonijevic

Keyword(s):

Experimental Study ◽

Thyroid Hormone ◽

Endocrine Disrupting Chemicals ◽

Hormone Levels ◽

Endocrine Disrupting ◽

Thyroid Hormone Levels

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Exposure to Indoor Endocrine-Disrupting Chemicals and Childhood Asthma and Obesity

PEDIATRICS ◽

10.1542/peds.2020-023861u ◽

2020 ◽

Vol 146 (Supplement 4) ◽

pp. S333.1-S333

Author(s):

Stuart L. Abramson

Keyword(s):

Childhood Asthma ◽

Endocrine Disrupting Chemicals ◽

Endocrine Disrupting

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Faculty Opinions recommendation of Sex-specific enhanced behavioral toxicity induced by maternal exposure to a mixture of low dose endocrine-disrupting chemicals.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725254111.793504008 ◽

2015 ◽

Author(s):

Martin van den Berg ◽

Milou Dingemans

Keyword(s):

Low Dose ◽

Endocrine Disrupting Chemicals ◽

Maternal Exposure ◽

Behavioral Toxicity ◽

Endocrine Disrupting

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Effect of Polyphosphate on Removal of Endocrine-Disrupting Chemicals of Nonylphenol and Bisphenol-A by Activated Carbons

Water Quality Research Journal ◽

10.2166/wqrj.2005.052 ◽

2005 ◽

Vol 40 (4) ◽

pp. 484-490 ◽

Cited By ~ 5

Author(s):

Keun J. Choi ◽

Sang G. Kim ◽

Chang W. Kim ◽

Seung H. Kim

Keyword(s):

Activated Carbon ◽

Bisphenol A ◽

Surface Charge ◽

Activated Carbons ◽

Endocrine Disrupting Chemicals ◽

Dipole Interaction ◽

High Affinity ◽

Calcium Polyphosphate ◽

Endocrine Disrupting ◽

Positively Charged

Abstract This study examined the effect of polyphosphate on removal of endocrine-disrupting chemicals (EDCs) such as nonylphenol and bisphenol-A by activated carbons. It was found that polyphosphate aided in the removal of nonylphenol and bisphenol- A. Polyphosphate reacted with nonylphenol, likely through dipole-dipole interaction, which then improved the nonylphenol removal. Calcium interfered with this reaction by causing competition. It was found that polyphosphate could accumulate on carbon while treating a river. The accumulated polyphosphate then aided nonylphenol removal. The extent of accumulation was dependent on the type of carbon. The accumulation occurred more extensively with the wood-based used carbon than with the coal-based used carbon due to the surface charge of the carbon. The negatively charged wood-based carbon attracted the positively charged calcium-polyphosphate complex more strongly than the uncharged coal-based carbon. The polyphosphate-coated activated carbon was also effective in nonylphenol removal. The effect was different depending on the type of carbon. Polyphosphate readily attached onto the wood-based carbon due to its high affinity for polyphosphate. The attached polyphosphate then improved the nonylphenol removal. However, the coating failed to attach polyphosphate onto the coal-based carbon. The nonylphenol removal performance of the coal-based carbon remained unchanged after the polyphosphate coating.

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