Growth factor responsiveness and alterations in growth factor homeostasis in Syrian hamster embryo cells during in vitro transformation

1994 ◽  
Vol 15 (6) ◽  
pp. 1203-1209 ◽  
Author(s):  
Robert J. Isfort ◽  
David B. Cody ◽  
Gary A. Kerckaert ◽  
Robert A. LeBoeuf
Keyword(s):  
Growth Factor ◽  
Syrian Hamster ◽  
In Vitro Transformation ◽  
Hamster Embryo Cells ◽  
Embryo Cells

In vitro Transformation of Syrian Hamster Embryo Cells by Diverse Chemical Carcinogens

Nature ◽  
1972 ◽  
Vol 235 (5336) ◽  
pp. 278-280 ◽  
Author(s):  
J. A. DIPAOLO ◽  
R. L. NELSON ◽  
P. J. DONOVAN
Keyword(s):  
Syrian Hamster ◽  
Chemical Carcinogens ◽  
In Vitro Transformation ◽  
Hamster Embryo Cells ◽  
Embryo Cells

scholarly journals Coinfection with viruses carrying the v-Ha-ras and v-myc oncogenes leads to growth factor independence by an indirect mechanism.

1986 ◽  
Vol 6 (10) ◽  
pp. 3545-3549 ◽  
Author(s):  
M Vogt ◽  
J Lesley ◽  
J Bogenberger ◽  
S Volkman ◽  
M Haas
Keyword(s):  
Growth Rate ◽  
Growth Factor ◽  
Syrian Hamster ◽  
Great Variability ◽  
Chromosome 15 ◽  
Hamster Embryo Cells ◽  
Embryo Cells ◽  
Infected Cells ◽  
Tumorigenic Cells

The concomitant expression of certain oncogenes can transform normal diploid rodent cells into transplantable tumorigenic cells. The mechanism by which these oncogenes collaborate is unclear. Recent findings (M. Oshimura, T. M. Gilmer, and J. C. Barrett, Nature [London] 316:636-639, 1985) raise the possibility that karyotypic changes, including monosomy for chromosome 15, are required to induce tumorigenicity in Syrian hamster embryo cells transfected in vitro with v-Ha-ras and v-myc DNAs. We studied the effect of the oncogenes v-Ha-ras and v-myc, introduced by viral infection, on murine hematopoietic cells. The induction of growth factor independence by the two oncogenes was used as an in vitro correlate of tumorigenicity. After a period of reduced growth rate reminiscent of the growth rate of cells in crisis, the doubly infected cells became growth factor independent. These cells showed a great variability in their karyotypes.

Coinfection with viruses carrying the v-Ha-ras and v-myc oncogenes leads to growth factor independence by an indirect mechanism

1986 ◽  
Vol 6 (10) ◽  
pp. 3545-3549
Author(s):  
M Vogt ◽  
J Lesley ◽  
J Bogenberger ◽  
S Volkman ◽  
M Haas
Keyword(s):  
Growth Rate ◽  
Growth Factor ◽  
Syrian Hamster ◽  
Great Variability ◽  
Chromosome 15 ◽  
Hamster Embryo Cells ◽  
Embryo Cells ◽  
Infected Cells ◽  
Tumorigenic Cells

The concomitant expression of certain oncogenes can transform normal diploid rodent cells into transplantable tumorigenic cells. The mechanism by which these oncogenes collaborate is unclear. Recent findings (M. Oshimura, T. M. Gilmer, and J. C. Barrett, Nature [London] 316:636-639, 1985) raise the possibility that karyotypic changes, including monosomy for chromosome 15, are required to induce tumorigenicity in Syrian hamster embryo cells transfected in vitro with v-Ha-ras and v-myc DNAs. We studied the effect of the oncogenes v-Ha-ras and v-myc, introduced by viral infection, on murine hematopoietic cells. The induction of growth factor independence by the two oncogenes was used as an in vitro correlate of tumorigenicity. After a period of reduced growth rate reminiscent of the growth rate of cells in crisis, the doubly infected cells became growth factor independent. These cells showed a great variability in their karyotypes.

scholarly journals In vitro Transformation of Hamster Embryo Cells with Tryptophan Pyrolysis Products

1977 ◽  
Vol 53 (3) ◽  
pp. 126-129 ◽  
Author(s):  
Shozo TAKAYAMA ◽  
Yoichi KATOH ◽  
Machiko TANAKA ◽  
Minako NAGAO ◽  
Keiji WAKABAYASHI ◽  
...  
Keyword(s):  
Pyrolysis Products ◽  
In Vitro Transformation ◽  
Hamster Embryo Cells ◽  
Embryo Cells

In vitro transformation of hamster embryo cells with a glutamic acid pyrolysis product

1979 ◽  
Vol 4 (4) ◽  
pp. 281-284 ◽  
Author(s):  
T SHOZO ◽  
H TADASHI ◽  
T MACHIKO ◽  
K TAKASHI ◽  
S TAKASHI
Keyword(s):  
Glutamic Acid ◽  
Pyrolysis Product ◽  
In Vitro Transformation ◽  
Hamster Embryo Cells ◽  
Embryo Cells
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