Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases

Anna-Leena Salmela; Jeroen Pouwels; Jenni Mäki-Jouppila; Pekka Kohonen; Pauliina Toivonen; Lila Kallio; Marko Kallio

doi:10.1093/carcin/bgs339

Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases

Carcinogenesis ◽

10.1093/carcin/bgs339 ◽

2012 ◽

Vol 34 (2) ◽

pp. 436-445 ◽

Cited By ~ 3

Author(s):

Anna-Leena Salmela ◽

Jeroen Pouwels ◽

Jenni Mäki-Jouppila ◽

Pekka Kohonen ◽

Pauliina Toivonen ◽

...

Keyword(s):

Cell Viability ◽

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Aurora Kinases

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Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis

Pediatric Blood & Cancer ◽

10.1002/pbc.24653 ◽

2013 ◽

Vol 60 (11) ◽

pp. 1809-1816 ◽

Cited By ~ 17

Author(s):

Kleiton Silva Borges ◽

Daniel Antunes Moreno ◽

Carlos Eduardo Martinelli ◽

Sonir Roberto Rauber Antonini ◽

Margaret de Castro ◽

...

Keyword(s):

Gene Expression ◽

Poor Prognosis ◽

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Aurora Kinases ◽

Checkpoint Gene ◽

Adrenocortical Tumors

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Mitosis and the spindle assembly checkpoint

AccessScience ◽

10.1036/1097-8542.yb100046 ◽

2015 ◽

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly

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Faculty Opinions recommendation of DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1010362.151807 ◽

2002 ◽

Author(s):

Orna Cohen-Fix

Keyword(s):

Dna Damage ◽

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Human Cells

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Faculty Opinions recommendation of Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1028986.343451 ◽

2005 ◽

Author(s):

Kevin Hardwick

Keyword(s):

Saccharomyces Cerevisiae ◽

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Checkpoint Genes

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Faculty Opinions recommendation of Kinetochore stretching inactivates the spindle assembly checkpoint.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158324.621194 ◽

2009 ◽

Author(s):

Silke Hauf

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly

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Faculty Opinions recommendation of A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1168499.630692 ◽

2009 ◽

Author(s):

Marie-Hélène Verlhac ◽

Marie-Emilie Terret

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Checkpoint Protein ◽

Prophase I ◽

Protein Functions ◽

Spindle Assembly Checkpoint Protein

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Faculty Opinions recommendation of The spindle assembly checkpoint works like a rheostat rather than a toggle switch.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718133718.793486404 ◽

2013 ◽

Author(s):

Keith Jones

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Toggle Switch

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Faculty Opinions recommendation of Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718194584.793491552 ◽

2014 ◽

Author(s):

Dean Dawson

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Meiosis I

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Faculty Opinions recommendation of Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718194584.793488086 ◽

2013 ◽

Author(s):

Marie-Hélène Verlhac ◽

Marie-Emilie Terret

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Meiosis I

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Faculty Opinions recommendation of The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725540369.793508165 ◽

2015 ◽

Author(s):

Kevin Hardwick

Keyword(s):

Spindle Assembly Checkpoint ◽

Spindle Assembly ◽

Mechanical Switch

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