scholarly journals A Simple Gas Chromatographic Method for the Simultaneous Determination and Pharmacokinetic Study of Tetramethylpyrazine Phosphate and Borneol in Mouse Plasma and Brain Tissue After Oral Administration of the Fufang Tetramethylpyrazine Phosphate Tablets

2008 ◽  
Vol 46 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Y.-y. Xiao ◽  
Q.-n. Ping ◽  
Z.-p. Chen
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Brain Tissue ◽  
Pharmacokinetic Study ◽  
Chromatographic Method ◽  
Mouse Plasma ◽  
Tetramethylpyrazine Phosphate ◽  
Gas Chromatographic Method

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

scholarly journals Rapid Gas Chromatographic Method for Simultaneous Determination of Cholesterol and α-Tocopherol in Eggs

1998 ◽  
Vol 81 (6) ◽  
pp. 1177-1184 ◽  
Author(s):  
Nickos Botsoglou ◽  
Dimitrios Fletouris ◽  
Ioannis Psomas ◽  
Antonios Mantis
Keyword(s):  
Simultaneous Determination ◽  
Chromatographic Method ◽  
Labor Cost ◽  
Precision Data ◽  
Total Analysis Time ◽  
Accuracy And Precision ◽  
Relative Standard ◽  
Total Analysis ◽  
Gas Chromatographic Method

Abstract A new method was developed for simultaneous determination of cholesterol and α-tocopherol in eggs. It involves rapid and simple sample preparation accomplished in one tube and chromatographic separation that does not require derivatization of analytes. Total analysis time per sample is 40 min. Labor, cost, and use of hazardous chemicals are minimized. To ensure selectivity, accuracy, and precision, critical analytical parameters were investigated. Overall recoveries were 98.8 and 99.2% for cholesterol and α-tocopherol, respectively. Linearity was acceptable for both analytes (r = 0.9964 for cholesterol and 0.9996 for α-tocopherol) in the fortification range examined. Precision data based on within-day and between-days variation gave overall relative standard deviations of 2.0% for cholesterol and 7.0% for α-tocopherol.The method was applied successfully for quantitation of cholesterol and α-tocopherol in eggs.

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