scholarly journals Homochiral Metal–Organic Framework [Co(L)(bpe)2(H2O)2]·H2O Used for Separation of Racemates in High-Performance Liquid Chromatography

2021 ◽  
Author(s):  
Yunyan Yu ◽  
Baoyan Yuan ◽  
Cong Hu ◽  
Nan Fu ◽  
Nayan Xu ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Metal Organic Framework ◽  
Hplc Separation ◽  
Relative Standard ◽  
Metal Organic ◽  
Cyclohexanedicarboxylic Acid ◽  
Organic Framework

Abstract A homochiral metal–organic framework (MOF) comprising [Co(L)(bpe)2(H2O)2]·H2O was prepared using (1R,2R)-(−)-1,2-cyclohexanedicarboxylic acid (H2L) and 1,2-bis(4-pyridyl)-ethylene as organic ligands. The homochiral MOF [Co(L)(bpe)2(H2O)2]·H2O was explored as chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC) separation of racemates. Nine racemates including naphthol, alcohol, diol, amine, ketone, ether and organic acid were well separated on the homochiral MOF [Co(L)(bpe)2(H2O)2]·H2O column (250 mm long × 4.6 mm i.d.). The relative standard deviation for five replicate separations of 1,1′-bi-2-naphthol is 0.69% for the retention time, indicating that the good reproducibility and stability of the homochiral MOF column for HPLC enantioseparation. The results indicated that the homochiral MOF as CSP is practical, which promotes the application of homochiral MOFs in HPLC.

scholarly journals Reusable and sustainable graphene oxide/metal–organic framework-74/Fe3O4/polytyramine nanocomposite for simultaneous trace level quantification of five fluoroquinolones in egg samples by high performance liquid chromatography

2021 ◽  
Vol 4 (02) ◽  
pp. 5-24
Author(s):  
Fatemeh Pourbahman ◽  
Mohsen Zeeb ◽  
Amirhossein Monzavi ◽  
Zahra Khodadadi ◽  
Seyed Saied Homami
Keyword(s):  
High Performance Liquid Chromatography ◽  
Graphene Oxide ◽  
Liquid Chromatography ◽  
High Performance ◽  
Solid Phase ◽  
Metal Organic Framework ◽  
Oxidative Polymerization ◽  
X Ray ◽  
Metal Organic ◽  
Organic Framework

A nanohybrid material termed graphene oxide/metal-organic framework-74/Fe3O4/polytyramine (GO/MOF-74/Fe3O4­/PTy) was fabricated and applied in magnetic dispersive micro-solid phase extraction (MD-µ-SPE) coupled with high performance liquid chromatography (HPLC) for simultaneous determination of fluoroquinolones compounds including, ofloxacin, ciprofloxacin, lomefloxacin, enrofloxacin and sperfloxacin in egg samples. The GO/MOF-74/Fe3O4/PTy nanocomposite was fabricated through an in situ synthesis of MOF-74 in the presence of magnetic GO and followed with an oxidative polymerization of tyramine using horsedish peroxide (HRP) enzyme. The modifier agents improved the merits of the nanoporous sorbent. Extraction protocols based on GO/MOF nanocomposites have various benefit such as, the high stability, the tunable porosity, the fast mast transfer and reasonable enrichment factor. The fabricated material was characterized via energy dispersive x-ray analysis (EDX), the scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and the x-ray diffraction (XRD). The calibration curves revealed linearity (0.992 ≤ r2 ≤ 0.997) in the ranges of 1.0-475.0, 0.5-350.0, 0.5-350.0, 0.5-375.0 and 1.5-300.0 ng mL-1 with limit of detections (LODs, S/N=3) of 0.3, 0.1, 0.2, 0.1 and 0.4 ng mL-1 for ofloxacin, ciprofloxacin, lomefloxacin, enrofloxacin and sperfloxacin, respectively. The intra-assay (≤7.7%, n = 9) and inter-assay (≤7.0%, n = 9) precisions along with accuracy less than 9.0% were obtained.

scholarly journals γ-Cyclodextrin metal–organic framework for efficient separation of chiral aromatic alcohols

RSC Advances ◽  
2017 ◽  
Vol 7 (58) ◽  
pp. 36297-36301 ◽  
Author(s):  
Cheng-Xiong Yang ◽  
Yu-Zhen Zheng ◽  
Xiu-Ping Yan
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Metal Organic Framework ◽  
Hplc Separation ◽  
Efficient Separation ◽  
Aromatic Alcohols ◽  
Metal Organic ◽  
Organic Framework

A γ-cyclodextrin metal–organic framework was applied as an efficient chiral stationary phase for HPLC separation of chiral aromatic alcohols.

scholarly journals Efficient resolution of racemic crown-shaped cyclotriveratrylene derivatives and isolation and characterization of the intermediate saddle isomer

2019 ◽  
Vol 15 ◽  
pp. 1339-1346
Author(s):  
Sven Götz ◽  
Andreas Schneider ◽  
Arne Lützen
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Nmr Spectroscopy ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Hplc Separation ◽  
Promising Alternative ◽  
Isolation And Characterization ◽  
C Nmr

The preparative resolution of a trifunctionalized C 3-symmetrical chiral cyclotriveratrylene derivative was achieved via high-performance liquid chromatography (HPLC) on a chiral stationary phase. This approach is a promising alternative to the previously reported resolution through formation of diastereomeric esters because it involves fewer synthetic steps and is less prone to thermal (re)racemization. During these studies an intermediate saddle conformer could also be isolated and characterized by 1H and 13C NMR spectroscopy. The HPLC separation method was further developed in order to allow investigations on the racemization behavior of the cyclotriveratrylene derivative.

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