Electrophoresis of serum protein to detect alpha 1-antitrypsin deficiency: five illustrative cases.
Keyword(s):
Abstract We describe five cases of severe alpha 1-antitrypsin (AAT) deficiency to illustrate the importance of visual inspection of electrophoretic patterns of serum proteins. In four patients the diagnosis of AAT deficiency was clinically unsuspected; in the other patient, the electrophoretic pattern was the first clue to confirm the diagnosis. Densitometric scanning of these patterns invariably overestimated the concentration of alpha 1-globulin. By visually inspecting electrophoretic strips instead of relying on densitometry, clinical chemists can help detect AAT deficiency earlier.
2017 ◽
Vol 4
(3)
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pp. 204-216
2000 ◽
Vol 15
(2)
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pp. 171-173
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1995 ◽
Vol 131
(10)
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pp. 1175-1177
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