scholarly journals Chromatin modifications remodel cardiac gene expression

2014 ◽  
Vol 103 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Prabhu Mathiyalagan ◽  
Samuel T. Keating ◽  
Xiao-Jun Du ◽  
Assam El-Osta
Keyword(s):  
Gene Expression ◽  
Chromatin Modifications ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Doppler Echocardiographic Assessment and Cardiac Gene Expression Analysis of the Left Ventricle in Myocardial lnfarcted Rats

1998 ◽  
Vol 62 (6) ◽  
pp. 436-442 ◽  
Author(s):  
Naruhito Shimizu ◽  
Minoru Yoshiyama ◽  
Kazuhide Takeuchi ◽  
Akihisa Hanatani ◽  
Shokei Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Left Ventricle ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Echocardiographic Assessment

scholarly journals Myocardin Marks the Earliest Cardiac Gene Expression and Plays an Important Role in Heart Development

2008 ◽  
Vol 291 (10) ◽  
pp. 1200-1211 ◽  
Author(s):  
Jian-Fu Chen ◽  
Shusheng Wang ◽  
Qiulian Wu ◽  
Dongsun Cao ◽  
Thiha Nguyen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Development ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

Abstract 247: Scaffold-stiffness Dependent Notch1 Activation Regulates Cardiogenic Gene Expression In Cardiac Progenitor Cells

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Archana V Boopathy ◽  
Pao L Che ◽  
Yoshie Narui ◽  
Khalid Salaita ◽  
Michael E Davis
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Cardiac Function ◽  
Progenitor Cells ◽  
Adult Stem Cells ◽  
Cardiac Progenitor Cells ◽  
Critical Pathway ◽  
Cardiac Gene Expression ◽  
Self Assembling ◽  
Cardiac Gene

Rationale: Cardiac progenitor cells (CPCs) are multipotent, self-renewing cells that can regenerate the myocardium and improve cardiac function in animal models of myocardial infarction (MI). However, limited survival of stem/progenitor cells inhibits cardiac regeneration. Force dependent Notch activation promotes cardiac development and cardiac gene expression in many adult stem cells. As dysregulation of Notch signaling leads to embryonic lethal cardiovascular defects, activating this critical pathway during cell transplantation could improve efficacy of stem cell therapy. Objective: Investigate i) whether self-assembling peptide scaffolds can be used to activate Notch1 signaling in CPCs to promote cardiogenic differentiation and ii) the effect of scaffold stiffness on Notch1 activation and differentiation. Methods: Rat CPCs (c-kit + ) were cultured for 48h in 3D self-assembling scaffolds of varying stiffness (1% low, 2% high): empty scaffolds (RADA), scaffolds modified with peptide mimicking Notch1 ligand, Jagged1 (RJAG), or scaffolds modified with a scrambled peptide (RSCR) and cardiogenic gene expression measured by qRT-PCR. CHO cells expressing Notch1 responsive YFP were also cultured in the above scaffolds for 48h and YFP expression was determined. Results are mean ± SEM with p<0.05 considered significant by one or two-way ANOVA with appropriate post test. Results: In the Notch1 reporter cells, Notch1 activation increased significantly in presence of RJAG (p<0.01) and on increasing scaffold stiffness (p<0.01,n=6) indicating scaffold stiffness-dependent Notch1 activation. Culture of CPCs in RJAG containing 1% scaffolds (low stiffness) significantly increased early endothelial and smooth muscle but not cardiac gene expression while in 2% scaffolds (high stiffness) significantly increased only cardiac and not endothelial or smooth muscle gene expression (p<0.05, n≥4). Conclusions: Taken together, these data show that i) Notch1 activation in 3D is dependent on ligand density and scaffold stiffness and ii) stiffness dependent Notch1 activation differentially regulates cardiogenic gene expression in CPCs. Therefore, delivery of CPCs in JAG containing scaffolds could be used to improve cardiac function following MI.

scholarly journals Corrigendum to “Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis” [Dev. Biol. 297 (2006) 566–586]

2007 ◽  
Vol 309 (2) ◽  
pp. 386
Author(s):  
Allesandro D. Mori ◽  
Yonghong Zhu ◽  
Ilyas Vahora ◽  
Brian Nieman ◽  
Kazuko Koshiba-Takeuchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

Multifactorial Regulation of Cardiac Gene Expression: an In Vivo and In Vitro Analysis

1995 ◽  
Vol 752 (1 Cardiac Growt) ◽  
pp. 370-386 ◽  
Author(s):  
J. L. SAMUEL ◽  
I. DUBUS ◽  
F. FARHADIAN ◽  
F. MAROTTE ◽  
P. OLIVIERO ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Vitro Analysis ◽  
In Vitro Analysis

scholarly journals Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174242 ◽  
Author(s):  
Tareq Al-Maqtari ◽  
Kyung U. Hong ◽  
Bathri N. Vajravelu ◽  
Afsoon Moktar ◽  
Pengxiao Cao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Progenitor Cells ◽  
Cardiac Progenitor Cells ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Adenosine-Induced Cardiac Gene Expression of Ischemic Murine Hearts Revealed by cDNA Array Hybridization

2002 ◽  
Vol 66 (1) ◽  
pp. 93-93 ◽  
Author(s):  
Masanori Asakura ◽  
Masafumi Kitakaze ◽  
Yasuhiko Sakata ◽  
Hiroshi Asanuma ◽  
Shoji Sanada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cdna Array ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Array Hybridization

Effects of losartan on pressure overload-induced cardiac gene expression profiling in rats

2003 ◽  
Vol 30 (11) ◽  
pp. 827-832 ◽  
Author(s):  
Jinliang Li ◽  
Ping Li ◽  
Xinheng Feng ◽  
Zhaoping Li ◽  
Rong Hou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Pressure Overload ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Cardiac-specific Knock-out of Lipoprotein Lipase Alters Plasma Lipoprotein Triglyceride Metabolism and Cardiac Gene Expression

2004 ◽  
Vol 279 (24) ◽  
pp. 25050-25057 ◽  
Author(s):  
Ayanna Augustus ◽  
Hiroaki Yagyu ◽  
Guenter Haemmerle ◽  
André Bensadoun ◽  
Reeba K. Vikramadithyan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lipoprotein Lipase ◽  
Plasma Lipoprotein ◽  
Triglyceride Metabolism ◽  
Knock Out ◽  
Cardiac Gene Expression ◽  
Cardiac Gene
Sign in / Sign up

Export Citation Format

Share Document