Tissue Angiotensin II System in the Human Heart

1994 ◽  
Vol 15 (suppl D) ◽  
pp. 68-78 ◽  
Author(s):  
H. Urata ◽  
S. Hoffmann ◽  
D. Ganten
Keyword(s):  
Angiotensin Ii ◽  
Human Heart ◽  
Tissue Angiotensin

Regulation of Local Angiotensin II Formation in the Human Heart in the Presence of Interstitial Fluid

Circulation ◽  
1997 ◽  
Vol 95 (6) ◽  
pp. 1455-1463 ◽  
Author(s):  
Jorma O. Kokkonen ◽  
Juhani Saarinen ◽  
Petri T. Kovanen
Keyword(s):  
Angiotensin Ii ◽  
Human Heart ◽  
Interstitial Fluid

scholarly journals Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

1990 ◽  
Vol 265 (36) ◽  
pp. 22348-22357 ◽  
Author(s):  
H Urata ◽  
A Kinoshita ◽  
K S Misono ◽  
F M Bumpus ◽  
A Husain
Keyword(s):  
Angiotensin Ii ◽  
Human Heart

scholarly journals Intracrine angiotensin II functions originate from noncanonical pathways in the human heart

2016 ◽  
Vol 311 (2) ◽  
pp. H404-H414 ◽  
Author(s):  
Carlos M. Ferrario ◽  
Sarfaraz Ahmad ◽  
Jasmina Varagic ◽  
Che Ping Cheng ◽  
Leanne Groban ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Functional Significance ◽  
Vascular Remodeling ◽  
Human Heart ◽  
Renin Angiotensin System ◽  
Ang Ii ◽  
Extended Form ◽  
Angiotensin I ◽  
Angiotensin System ◽  
Ras Genes

Although it is well-known that excess renin angiotensin system (RAS) activity contributes to the pathophysiology of cardiac and vascular disease, tissue-based expression of RAS genes has given rise to the possibility that intracellularly produced angiotensin II (Ang II) may be a critical contributor to disease processes. An extended form of angiotensin I (Ang I), the dodecapeptide angiotensin-(1–12) [Ang-(1–12)], that generates Ang II directly from chymase, particularly in the human heart, reinforces the possibility that an alternative noncanonical renin independent pathway for Ang II formation may be important in explaining the mechanisms by which the hormone contributes to adverse cardiac and vascular remodeling. This review summarizes the work that has been done in evaluating the functional significance of Ang-(1–12) and how this substrate generated from angiotensinogen by a yet to be identified enzyme enhances knowledge about Ang II pathological actions.

Tissue Angiotensin II as a Modulator of Erectile Function. I. Angiotensin Peptide Content, Secretion and Effects in the Corpus Cavernosum

1997 ◽  
Vol 157 (5) ◽  
pp. 1920-1925 ◽  
Author(s):  
Imre Kifor ◽  
Gordon H. Williams ◽  
Martyn A. Vickers ◽  
Maryrose P. Sullivan ◽  
Patrice Jodbert ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Erectile Function ◽  
Corpus Cavernosum ◽  
Angiotensin Peptide ◽  
Tissue Angiotensin

scholarly journals Differences in Tissue Angiotensin II–Forming Pathways by Species and Organs In Vitro

Hypertension ◽  
1998 ◽  
Vol 32 (3) ◽  
pp. 514-520 ◽  
Author(s):  
Maki Akasu ◽  
Hidenori Urata ◽  
Akio Kinoshita ◽  
Manabu Sasaguri ◽  
Munehito Ideishi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Tissue Angiotensin

Tissue Angiotensin II as a Modulator of Erectile Function. I. Angiotensin Peptide Content, Secretion and Effects in the Corpus Cavernosum

1997 ◽  
pp. 1920-1925 ◽  
Author(s):  
Imre Kifor ◽  
Gordon H. Williams ◽  
Martyn A. Vickers ◽  
Maryrose P. Sullivan ◽  
Patrice Jodbert ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Erectile Function ◽  
Corpus Cavernosum ◽  
Angiotensin Peptide ◽  
Tissue Angiotensin
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