scholarly journals Age-Related Differences in the Effect of Running Training on Cardiac Myosin Isozyme Composition in Rats

2002 ◽  
Vol 57 (9) ◽  
pp. B339-B343 ◽  
Author(s):  
S. Machida ◽  
H. Tsujimoto ◽  
H. Suzuki ◽  
N. Kasuga ◽  
K. Kobayashi ◽  
...  
Keyword(s):  
Cardiac Myosin ◽  
Running Training ◽  
Age Related ◽  
Myosin Isozyme

scholarly journals Lack of Effect of Running Training at Two Intensities on Cardiac Myosin Isozyme Composition in Rats.

2000 ◽  
Vol 50 (6) ◽  
pp. 577-583 ◽  
Author(s):  
Shuichi Machida ◽  
Fumihiko Kariya ◽  
Keizo Kobayashi ◽  
Mitsuo Narusawa
Keyword(s):  
Cardiac Myosin ◽  
Running Training ◽  
Myosin Isozyme

Effects of exercise on cardiac myosin isozyme composition during the aging process

1988 ◽  
Vol 64 (2) ◽  
pp. 880-883 ◽  
Author(s):  
R. P. Farrar ◽  
J. W. Starnes ◽  
G. D. Cartee ◽  
P. Y. Oh ◽  
H. L. Sweeney
Keyword(s):  
Atpase Activity ◽  
Exercise Program ◽  
Cardiac Performance ◽  
Fischer 344 Rats ◽  
Cardiac Myosin ◽  
Equal Distribution ◽  
Fischer 344 ◽  
Age Related ◽  
Myosin Isozyme ◽  
Effects Of Aging

The effects of aging and exercise on isoforms of cardiac myosin and Ca2+-activated actomyosin adenosinetriphosphatase (ATPase) activity were examined in Fischer 344 rats. Rats were divided into running (R) and age-matched sedentary (S) groups. The groups initiated their exercise program at either 3, 4, or 18 mo of age. Rats were killed at 10, 12, 24, or 27 mo of age. ATPase activity decreased 25% in the S group and 28% in the R group from 12 to 27 mo of age. The myosin isozyme patterns shifted in both S and R groups from a predominantly V1 isozyme form (63.8%) at 10 mo of age to a more equal distribution of isozyme forms at 24 mo (V1, V2, and V3 comprising 40.0, 27.8, and 31.9%, respectively). Age-related shifts in myosin composition occurred despite chronic endurance training at an intensity of approximately 75% maximum O2 consumption. Improvement of cardiac performance through training during aging is not accompanied by attenuating shifts in myosin isozyme composition.

scholarly journals Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction

2019 ◽  
Vol 4 (7) ◽  
pp. 817-830 ◽  
Author(s):  
Paola C. Rosas ◽  
Chad M. Warren ◽  
Heidi A. Creed ◽  
Jerome P. Trzeciakowski ◽  
R. John Solaro ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Protein C ◽  
Binding Protein ◽  
Cardiac Myosin ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Age Related ◽  
Myosin Binding

Prevention of Age-related V1 Myosin Isozyme Decrement in the Adult Rat Heart

1994 ◽  
Vol 26 (3) ◽  
pp. 293-296 ◽  
Author(s):  
Veena Raizada ◽  
Dorothy Pathak ◽  
Antonio Nakouzi ◽  
Ashwani Malhotra
Keyword(s):  
Rat Heart ◽  
Adult Rat ◽  
Age Related ◽  
Myosin Isozyme

Exercise alters cardiac myosin isozyme distribution in obese Zucker and Wistar rats

1990 ◽  
Vol 69 (1) ◽  
pp. 380-383 ◽  
Author(s):  
G. S. Morris ◽  
K. M. Baldwin ◽  
J. M. Lash ◽  
R. L. Hamlin ◽  
W. M. Sherman
Keyword(s):  
Exercise Training ◽  
Atpase Activity ◽  
Functional Capacity ◽  
Wistar Rats ◽  
Cardiac Contractility ◽  
Cardiac Myosin ◽  
Endurance Exercise Training ◽  
Obese Rats ◽  
Myosin Isozyme ◽  
Glucose Availability

Recent evidence suggests that exercise training may significantly increase the expression of the cardiac myosin isozyme V1 in the diabetic heart, a change associated with improved cardiac functional capacity. To test this hypothesis, cardiac myofibrillar adenosinetriphosphatase (ATPase) activity and myosin isozyme profiles were determined in trained and sedentary male hyperinsulinemic obese Zucker (OZT, OZS) and obese Wistar (OWT, OWS) rats. Lean sedentary (LZS, LWS) animals served as age-matched controls. Myofibrillar ATPase activity and the relative quantity of the high-ATPase isozyme V1 was significantly lower in both strains of sedentary obese rats than in the respective lean sedentary controls (P less than 0.05). Both 5 (OZT) and 10 wk (OWT) of moderate treadmill training increased these markers of cardiac myosin biochemistry in the obese animals (P less than 0.05). Thus, endurance exercise training remodels the cardiac isomyosin profile of hyperinsulinemic rats and, in doing so, may enhance cardiac contractility and functional capacity. Such changes may reflect an improvement in glucose availability and utilization in these hearts.

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