The genomic structure of the human skeletal muscle sodium channel gene

1992 ◽  
Vol 1 (7) ◽  
pp. 521-527 ◽  
Author(s):  
Andrea I.McClatchey ◽  
Carol S.Lin ◽  
Jianzhou Wang ◽  
Eric P.Hoffman ◽  
Cecilia Rojas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channel ◽  
Human Skeletal Muscle ◽  
Genomic Structure ◽  
Channel Gene ◽  
Sodium Channel Gene

Genomic Organization of the Human Skeletal Muscle Sodium Channel Gene

Genomics ◽  
1993 ◽  
Vol 15 (3) ◽  
pp. 598-606 ◽  
Author(s):  
Alfred L. George ◽  
Geeta S. Iyer ◽  
Robert Kleinfield ◽  
Roland G. Kallen ◽  
Robert L. Barchi
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channel ◽  
Human Skeletal Muscle ◽  
Genomic Organization ◽  
Channel Gene ◽  
Sodium Channel Gene

scholarly journals Salbutamol treatment in a patient with hyperkalaemic periodic paralysis due to a mutation in the skeletal muscle sodium channel gene (SCN4A)

1998 ◽  
Vol 65 (2) ◽  
pp. 248-250 ◽  
Author(s):  
M G Hanna ◽  
J Stewart ◽  
A H V Schapira ◽  
N W Wood ◽  
J A Morgan-Hughes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channel ◽  
Periodic Paralysis ◽  
Channel Gene ◽  
Sodium Channel Gene

Temperature-sensitive mutations in the III–IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita

Cell ◽  
1992 ◽  
Vol 68 (4) ◽  
pp. 769-774 ◽  
Author(s):  
Andrea I. McClatchey ◽  
Peter Van den Bergh ◽  
Margaret A. Pericak-Vance ◽  
Wendy Raskind ◽  
Christine Verellen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channel ◽  
Temperature Sensitive ◽  
Cytoplasmic Loop ◽  
Paramyotonia Congenita ◽  
Channel Gene ◽  
Sodium Channel Gene ◽  
Loop Region

Identification of a Thr-to-Met Mutation in the Skeletal Muscle Sodium Channel Gene in Hyperkalemic Periodic Paralysis of a Japanese Family

1993 ◽  
Vol 707 (1 Molecular Bas) ◽  
pp. 342-345
Author(s):  
KIICHI ARAHATA ◽  
JIANZHOU WANG ◽  
W. GREGORY FEERO ◽  
HIROSHI HAYAKAWA ◽  
KOICHI HONDA ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channel ◽  
Periodic Paralysis ◽  
Hyperkalemic Periodic Paralysis ◽  
Japanese Family ◽  
Channel Gene ◽  
Sodium Channel Gene

scholarly journals Permethrin Resistance in Aedes aegypti Affects Aspects of Vectorial Capacity

Insects ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 71
Author(s):  
Tse-Yu Chen ◽  
Chelsea T. Smartt ◽  
Dongyoung Shin
Keyword(s):  
Aedes Aegypti ◽  
Sodium Channel ◽  
Mosquito Control ◽  
Vector Competence ◽  
Vectorial Capacity ◽  
Parental Population ◽  
Control Programs ◽  
Channel Gene ◽  
Sodium Channel Gene ◽  
Specific Pcr

Aedes aegypti, as one of the vectors transmitting several arboviruses, is the main target in mosquito control programs. Permethrin is used to control mosquitoes and Aedes aegypti get exposed due to its overuse and are now resistant. The increasing percentage of permethrin resistant Aedes aegypti has become an important issue around the world and the potential influence on vectorial capacity needs to be studied. Here we selected a permethrin resistant (p-s) Aedes aegypti population from a wild Florida population and confirmed the resistance ratio to its parental population. We used allele-specific PCR genotyping of the V1016I and F1534C sites in the sodium channel gene to map mutations responsible for the resistance. Two important factors, survival rate and vector competence, that impact vectorial capacity were checked. Results indicated the p-s population had 20 times more resistance to permethrin based on LD50 compared to the parental population. In the genotyping study, the p-s population had more homozygous mutations in both mutant sites of the sodium channel gene. The p-s adults survived longer and had a higher dissemination rate for dengue virus than the parental population. These results suggest that highly permethrin resistant Aedes aegypti populations might affect the vectorial capacity, moreover, resistance increased the survival time and vector competence, which should be of concern in areas where permethrin is applied.

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