Localization of a locus for the striated form of palmoplantar keratoderma to chromosome 18q near the desmosomal cadherin gene cluster

1995 ◽  
Vol 4 (6) ◽  
pp. 1015-1020 ◽  
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Hans-Christian Hennies ◽  
Wolfgang Küster ◽  
Dietmar Mischke ◽  
André Reis
1992 ◽  
Vol 90 (1-2) ◽  
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Andr� Reis ◽  
Wolfgang K�ster ◽  
Ralf Eckardt ◽  
Karl Sperling

2020 ◽  
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Alexandra Kitz ◽  
Ignat Drozdov ◽  
Irvin Modlin

2002 ◽  
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Satoshi FUKUSHIMA ◽  
Mika KINOSHITA ◽  
Junko HIGO ◽  
Masato KIDOU ◽  
Fukiko AMANO ◽  
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2018 ◽  
Vol 80 (6) ◽  
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Takahito CHIBA ◽  
Hiromaro KIRYU ◽  
Masutaka FURUE

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Niina Leikoski ◽  
Matti Wahlsten ◽  
Joana Azevedo ◽  
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...  

Cyanobactins are a family of linear and cyclic peptides produced through the post-translational modification of short precursor peptides. Anacyclamides are macrocyclic cyanobactins with a highly diverse sequence that are common in the genus <i>Anabaena</i>. A mass spectrometry-based screening of potential cyanobactin producers led to the discovery of a new prenylated member of this family of compounds, anacyclamide D8P (<b>1</b>), from <i>Sphaerospermopsis</i> sp. LEGE 00249. The anacyclamide biosynthetic gene cluster (<i>acy</i>) encoding the novel macrocyclic prenylated cyanobactin, was sequenced. Heterologous expression of the acy gene cluster in <i>Escherichia</i> <i>coli</i> established the connection between genomic and mass spectrometric data. Unambiguous establishment of the type and site of prenylation required the full structural elucidation of <b>1</b> using Nuclear Magnetic Resonance (NMR), which demonstrated that a forward prenylation occurred on the tyrosine residue. Compound <b>1</b> was tested in pharmacologically or ecologically relevant biological assays and revealed moderate antimicrobial activity towards the fouling bacterium <i>Halomonas aquamarina</i> CECT 5000.<br>


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