scholarly journals The efficacy of transbronchial indocyanine green instillation for fluorescent-guided wedge resection

Author(s):  
Yasuo Sekine ◽  
Eitetsu Koh ◽  
Hidehisa Hoshino

Abstract Central image: Virtual wedge resection of right S2aiiα+S2aiiβ and the same intraoperative fluorescent image. OBJECTIVES The purpose of this study was to investigate the feasibility of lung wedge resection by combining 3-dimensional (3D) image analysis with transbronchial indocyanine green (ICG) instillation, in order to delineate the intended area for resection. METHODS From December 2017 to July 2020, 28 patients undergoing wedge resection (17 primary lung cancers, 11 metastatic lung tumours) were enrolled, and fluorescence-guided wedge resection was attempted. Virtual sublobar resections were created preoperatively for each patient using a 3D Image Analyzer. Surgical margins were measured in each sublobar resection simulation in order to select the most optimal surgical resection area. After transbronchial instillation of ICG, near-infrared thoracoscopic visualization allowed matching of the intended area for resection to the virtual sublobar resection area. To investigate the effectiveness of ICG instillation, the clarity of the ICG-florescent border was evaluated, and the distance from the true tumour to the surgical margins was compared to that of simulation. RESULTS Mean tumour diameter was 12.4 ± 4.3 mm. The entire targeted tumour was included in resected specimens of all patients (100% success rate). The shortest distances to the surgical margin via 3D simulation and by actual measurement of the specimen were11.4 ± 5.4 and 12.2 ± 4.1 mm, respectively (P = 0.285) and were well correlated (R2 = 0.437). While all specimens had negative malignant cells at the surgical margins, one loco-regional recurrence was observed secondary to the dissemination of neuroendocrine carcinoma. CONCLUSIONS ICG-guided lung wedge resection after transbronchial ICG instillation and preoperative 3D image analysis allow for adequate negative surgical margins, providing decreased risk of local recurrence.

2008 ◽  
Vol 91 (12) ◽  
pp. 16-23
Author(s):  
Mitsuru Nakazawa ◽  
Yoshimitsu Aoki ◽  
Hiroyuki Toda ◽  
Masakazu Kobayashi

2020 ◽  
Vol 104 (3-4) ◽  
pp. 188-193
Author(s):  
Koichi Tomita ◽  
Yuki Nakamura ◽  
Takayoshi Yokoyama ◽  
Naokazu Chiba ◽  
Yu Kihara ◽  
...  

Background: The perfusion areas of renal arteries in renal transplantation are assessed via subjective observations during perfusion in a bench surgery; however, this evaluation method lacks reliability and objectivity. In this study, we aimed to evaluate the perfusion area of each main and side artery kidney graft using a 3-dimensional (3D) image analysis system. Methods: We enrolled 50 patients who had undergone living kidney transplantation with multiple renal artery grafting at our center between 2005 and 2017. All computed tomography images from donors were retrospectively analyzed using a 3D image analysis system. We then calculated the artery perfusion areas associated with the artery reconstruction method used. Results: The perfusion areas of side arteries, which were evaluated after surgery, were statistically different among cases employing different reconstruction methods (P < 0.001). The perfusion area of the ligated side arteries (volume, 10 mL; proportion, 6.1%) was smaller than that of the ligated side arteries where different reconstruction methods were used. Conclusion: A 3D image analysis system could provide an accurate visual representation of the vasculature prior to living donor transplantation. It could also enable calculation of perfusion area for each artery and preoperative prediction of the need for arterial reconstruction, thereby promoting safe kidney transplantation surgery.


Urology ◽  
2015 ◽  
Vol 86 (3) ◽  
pp. 534-538 ◽  
Author(s):  
Conrad M. Tobert ◽  
Toshio Takagi ◽  
Michael A. Liss ◽  
Hak Lee ◽  
Ithaar H. Derweesh ◽  
...  

2009 ◽  
Vol 34 (5) ◽  
pp. 815-828 ◽  
Author(s):  
Abdurrahim Akgundogdu ◽  
Rachid Jennane ◽  
Gabriel Aufort ◽  
Claude Laurent Benhamou ◽  
Osman Nuri Ucan

Author(s):  
Michael Brady ◽  
Xiao-Bo Pan ◽  
Veit Schenk ◽  
Melissa Terras ◽  
Paul Robertson ◽  
...  

It is agreed that stilus tablets are very important documentary sources, however they are the most difficult to decipher. The difficulties in deciphering them is due to the rough surface of the tablets, the low brightness contrast of the incisions, the dense wood-grain lines, and the badly stained and pitted nature of the tablets. All of these posit a challenge for conventional two-dimensional (2D) image analysis. This chapter aims to provide a system that would aid the historian in interpreting stilus tablets by improving the legibility of the tablets. It provides novel ways of determining the texts incised on the tablets. One of these is the use of three-dimensional (3D) image analysis techniques. Such a technique is capable of detecting incisions, compared to the 2D image analysis, and is portable and inexpensive. Another method that can be used is the use of shadow stereo. This method employs low raking angle light close to the plane of the tablet at different elevations. The chapter also discusses the image formation process and the process of choosing elevations for each azimuth direction. The chapter also includes a discussion on realizing the shadow stereo algorithm.


2019 ◽  
Vol 32 (2) ◽  
pp. 539-549 ◽  
Author(s):  
Pascal Salazar ◽  
Mario Di Napoli ◽  
Mostafa Jafari ◽  
Alibay Jafarli ◽  
Wendy Ziai ◽  
...  

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