scholarly journals Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

2017 ◽  
Vol 72 (12) ◽  
pp. 3334-3341 ◽  
Author(s):  
Lerato Hlaka ◽  
Michael-Jon Rosslee ◽  
Mumin Ozturk ◽  
Santosh Kumar ◽  
Suraj P Parihar ◽  
...  
Keyword(s):  
Delivery System ◽  
Minor Groove ◽  
Ionic Surfactant ◽  
Minor Groove Binders ◽  
Surfactant Vesicles ◽  
Groove Binders

scholarly journals Dissociation of minor groove binders from DNA: insights from metadynamics simulations

2008 ◽  
Vol 36 (18) ◽  
pp. 5910-5921 ◽  
Author(s):  
A. V. Vargiu ◽  
P. Ruggerone ◽  
A. Magistrato ◽  
P. Carloni
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

scholarly journals An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics

2017 ◽  
Vol 136 ◽  
pp. 561-572 ◽  
Author(s):  
Fraser J. Scott ◽  
Ryan J.O. Nichol ◽  
Abedawn I. Khalaf ◽  
Federica Giordani ◽  
Kirsten Gillingwater ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Anti Fungal ◽  
Groove Binders

Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA

Tetrahedron ◽  
2017 ◽  
Vol 73 (21) ◽  
pp. 3014-3024 ◽  
Author(s):  
Claudia Sissi ◽  
Luca Dovigo ◽  
Maria Laura Greco ◽  
Antonella Ciancetta ◽  
Stefano Moro ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

scholarly journals Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

2016 ◽  
Vol 12 ◽  
pp. 1348-1360 ◽  
Author(s):  
Svetlana V Vasilyeva ◽  
Vyacheslav V Filichev ◽  
Alexandre S Boutorine
Keyword(s):  
Minor Groove ◽  
Binding Parameters ◽  
Design And Synthesis ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Triple Helices ◽  
Gel Shift ◽  
Groove Binders

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used for the insertion of terminal azides or alkynes into TFOs and MGBs. The formation of stable triple helices by TFO-MGB conjugates was evaluated by gel-shift experiments. The presence of MGB in these conjugates did not affect the binding parameters (affinity and triplex stability) of the parent TFOs.

scholarly journals Fluorescence-Labeled Bis-benzamidines as Fluorogenic DNA Minor-Groove Binders: Photophysics and Binding Dynamics

2014 ◽  
Vol 21 (4) ◽  
pp. 1609-1619 ◽  
Author(s):  
Jorge Bordello ◽  
Mateo I. Sánchez ◽  
M. Eugenio Vázquez ◽  
José L. Mascareñas ◽  
Wajih Al-Soufi ◽  
...  
Keyword(s):  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

DNA minor groove binders as potential antitumor and antimicrobial agents

2004 ◽  
Vol 24 (4) ◽  
pp. 475-528 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Andrea Bovero ◽  
Francesca Fruttarolo ◽  
Delia Preti ◽  
Mojgan Aghazadeh Tabrizi ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders ◽  
Potential Antitumor
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