Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity

2020 ◽  
pp. 163-168
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins
Keyword(s):  
Laser Therapy ◽  
Retinopathy Of Prematurity ◽  
Intravitreal Bevacizumab ◽  
Peripheral Retina ◽  
Controlled Clinical Trial ◽  
Disease Development ◽  
Retinal Vessels ◽  
Randomized Controlled Clinical Trial ◽  
Zone Ii ◽  
Conventional Laser

The Bevacizumab Eliminates the Angiogenic Threat of Retinopathy of Prematurity (BEAT-ROP) study was a randomized, controlled clinical trial to determine whether intravitreal bevacizumab monotherapy was an effective therapy for treating zone I or zone II posterior stage 3+ (stage 3 with plus disease) retinopathy of prematurity (ROP). Intravitreal bevacizumab, as compared with conventional laser therapy, showed a significant benefit for zone I but not zone II disease. Development of peripheral retinal vessels (with possible recurrence of ROP) continued after treatment with intravitreal bevacizumab, but conventional laser therapy led to permanent destruction of the peripheral retina.

scholarly journals Functional and Structural Outcomes of Temporal Zone II-Sparing Laser Photocoagulation Combined with Intravitreal Bevacizumab in Retinopathy of Prematurity

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Eoi Jong Seo ◽  
Joo Yong Lee
Keyword(s):  
Treatment Group ◽  
Retinopathy Of Prematurity ◽  
Laser Photocoagulation ◽  
Combined Treatment ◽  
Intravitreal Bevacizumab ◽  
Late Complications ◽  
Refractive Errors ◽  
Retinal Vessels ◽  
Zone Ii

Background/Aim. The aim of the study was to investigate the outcomes of temporal Zone II-sparing laser photocoagulation combined with intravitreal bevacizumab (IVB) in patients with Type 1 retinopathy of prematurity (ROP) in Zone I.Methods. Medical records of 74 eyes of 37 infants were analysed. Only infants with Type 1 ROP in Zone I were included. Thirty-two eyes were treated with temporal-sparing laser + IVB. Both Zone I and temporal Zone II were spared to minimise potential visual field loss. Forty-two eyes were treated with laser alone conventionally. Early treatment outcomes, late complications, and refractive errors were analysed.Results. The mean gestational age and birth weight of the enrolled patients were 25.7 ± 2.5 weeks and 798.8 ± 440.2 g, respectively. In the combined treatment group, plus sign regression was achieved faster (12.1 ± 6.2 days vs. 25.6 ± 21.3 days,p=0.011) and retreatment was required less (0% vs. 23.8%,p=0.004) than in the laser-alone group. Retinal/preretinal haemorrhages occurred more often in the laser-alone group (42.9% vs. 9.4%,p=0.002). Normal development of temporal retinal vessels was also observed in twelve eyes in the combined treatment group. No differences in late complications or refractive errors were observed between the groups.Conclusion. Temporal Zone II-sparing laser treatment combined with IVB showed good early treatment outcome and temporal retinal vessels development.

Intravitreal pegaptanib combined with diode laser therapy for stage 3+ retinopathy of prematurity in zone I and posterior zone II

2012 ◽  
Vol 22 (5) ◽  
pp. 687-694 ◽  
Author(s):  
Rudolf Autrata ◽  
Inka Krejčířová ◽  
Kateřina Šenková ◽  
Marie Holoušová ◽  
Zdeněk Doležel ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Diode Laser ◽  
Retinopathy Of Prematurity ◽  
Zone Ii

scholarly journals Persistence of Retinopathy of Prematurity in an Infant with Tetralogy of Fallot

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Murat Gunay ◽  
Taner Yavuz ◽  
Gokhan Celik ◽  
Gunay Uludag
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Tetralogy Of Fallot ◽  
Retinopathy Of Prematurity ◽  
Peripheral Retina ◽  
Demarcation Line ◽  
Probable Reason ◽  
Zone Ii ◽  
Index Subject

We report an infant with tetralogy of fallot (TOF) who was born at 35 weeks of gestation and of 1700 g birth weight and presented with persistent retinopathy of prematurity (ROP) at 6 months of age. Follow-up ophthalmic examinations were done at 2, 3, and 4 weeks of age. A demarcation line in Zone II was noticed on the first ocular examination done at 4 weeks of postnatal age. At 6 months of postnatal age, the infant still had an avascular peripheral retina with the demarcation line in Zone II. Even though this index subject did not have any typical risk factors for ROP, TOF seems to be the probable reason for developing as well as persistence of avascular retina.

scholarly journals Usefulness of Intravitreal Bevacizumab for Retinopathy of Prematurity with Severely Dilated Tunica Vasculosa Lentis and Poor Mydriasis

2017 ◽  
Vol 8 (1) ◽  
pp. 173-179 ◽  
Author(s):  
Tomoaki Higashiyama ◽  
Sanae Muraki ◽  
Masahito Ohji
Keyword(s):  
Birth Weight ◽  
Laser Therapy ◽  
Retinopathy Of Prematurity ◽  
Gold Standard ◽  
Standard Treatment ◽  
Intravitreal Bevacizumab ◽  
Male Infant ◽  
Significant Benefit ◽  
Tunica Vasculosa Lentis

Background: Laser therapy has been the gold standard treatment for retinopathy of prematurity (ROP), while intravitreal bevacizumab (IVB) is reported to be of significant benefit for zone I ROP. A problem with laser therapy is that it is difficult to administer in ROP patients with severely dilated tunica vasculosa lentis and poor mydriasis. However, although IVB treatment has been performed in such severe ROP cases, only 1 report has discussed its usefulness. Case 1: A male infant was born with a birth weight of 382 g at 23 weeks’ gestation. As visualization was poor and laser therapy could not be performed due to dilated tunica vasculosa lentis and poor mydriasis, IVB (0.625 mg/0.025 mL) was administered to both eyes. Following treatment, the ROP gradually improved, with regression of the dilated tunica vasculosa lentis and improvement of the mydriasis in both eyes. Case 2: A male infant was born with a birth weight of 698 g at 25 weeks’ gestation. As laser therapy could not be performed due to severely dilated tunica vasculosa lentis and poor mydriasis, IVB (0.625 mg/0.025 mL) was administered to both eyes. Following treatment, the ROP gradually improved, with regression of the dilated tunica vasculosa lentis and improvement of the mydriasis in both eyes. Conclusions: IVB is potentially more useful than laser therapy for the treatment of severe ROP with dilated tunica vasculosa lentis and poor mydriasis.

Intravitreal Bevacizumab for Zone II Retinopathy of Prematurity

2016 ◽  
Vol 53 (6) ◽  
pp. 375-382 ◽  
Author(s):  
Paula Larrañaga-Fragoso ◽  
Jesús Peralta ◽  
Luciano Bravo-Ljubetic ◽  
Natalia Pastora ◽  
José Abelairas-Gómez
Keyword(s):  
Retinopathy Of Prematurity ◽  
Intravitreal Bevacizumab ◽  
Zone Ii

Efficacy of intravitreal bevacizumab for zone-II retinopathy of prematurity

2016 ◽  
Vol 94 (6) ◽  
pp. e417-e420 ◽  
Author(s):  
Reza Karkhaneh ◽  
Alireza Khodabande ◽  
Mohammad Riazi-Eafahani ◽  
Ramak Roohipoor ◽  
Fariba Ghassemi ◽  
...  
Keyword(s):  
Retinopathy Of Prematurity ◽  
Intravitreal Bevacizumab ◽  
Zone Ii
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