Light-tissue interactions of low level laser to support the chronic hepatitis patients

In this paper, we present some results obtained from the simulation of low power 633, 780, 850, and 940 nm laser in the liver by Monte Carlo method, with the model of the liver, consisting of 5mm derm, 7mm subcutaneous fat, 5 mm muscle layer. Based on these results, we fabricated devices called “Laser Semiconductor Optoacupuncture and phototherapy Device” using 780 and 940nm semiconductor lasers to treat chronic hepatitis. We combined with the doctor in An Giang province to clinical practice for 50 voluntary patients with chronic hepatitis. We used a 650 nm wavelength intravascular semiconductor laser treatment clinically to provide high-quality blood to the patients’ liver. Treating the phototherapy of the skin with two semiconductor laser beams with 780 nm and 940 nm wavelengths directly affects the liver from the surface of the abdomen. At the moment, we use the treatment on acupoint with 940nm- wavelength laser. A treatment course consists of 20 times for the patients is treated continuously. The patients tested with the ALT and AST before and after treatment with 3 courses. We use the SPSS 23 statistical method to evaluate the outcomes of treatment. The clinical symptoms of the patients such as fatigue, nausea, indigestion, fever, jaundice, yellow eyes almost completely have gone out after treatment. Low-level laser therapy offers a good response in patients with moderate to severe hepatic impairment such as the AST of 56.380 ± 10.162 and 39.260 ± 4.869; The ALT of 56.540 ± 13.580 and 41,360 ± 7,488 for before- and after treatments, respectively. Low-level laser therapy for patients initially has good results, high therapeutic effectiveness, no catastrophic or side Effects, and the statistical significance is p < 0.001.This research applied the ethical principles of the Helsinki Declaration in human researches. The research was carried out using non-invasive methods on humans with the regulations of the University of Technology, Vietnam National University Ho Chi Minh City, and the relevant regulations.

Light Treatment for Healing Burns

This research aims to evaluate the effect of low-level laser therapy (LLLT) on the healing of the burn for the mouse. Four mouses are divided into 4 groups. Group 1, 2, 3 are irradiated by a wavelength of 532nm, 850nm, and 940nm. Group 4 is a control group that has a natural recovery. Low-level laser therapy makes the regenerative process, healing occurs faster, and rehabilitation of mouse activity during treatment.

Low-level laser therapy for treatment of tinnitus in Red Sea scuba divers: a randomized clinical study

Background Scuba diving has become a popular hobby. However, diving puts the auditory system at the risk of a wide variety of complaints including tinnitus. Low-level laser therapy is a new modality in treatment of tinnitus. This study evaluates effect of laser therapy on tinnitus of scuba divers in Red Sea. This randomized study included 200 scuba diving patients with tinnitus without any other audiological symptoms. They were randomly divided into two groups: GI (n=100) patients were subjected to 60 sessions of laser therapy, and in the other group GII (n=100), the machine was off while doing the procedure. The Tinnitus Questionnaire (TQ) was done every 20 days to evaluate the severity of the tinnitus for both groups. Results Both groups were matched regarding age and sex distribution. GI group experienced significantly decreased tinnitus severity compared to GII after laser therapy. There was no relation between duration of diving and laser therapy effect in GI. Conclusion Laser therapy is effective in treatment of tinnitus of scuba divers and its effect is increased by number of laser sessions.

Evaluation of biomarkers in the studies of keloid tissue after laser therapy

In this paper, we discuss what biomarkers to choose if there is a need to describe the results of laser therapy targeting keloid skin. We elevate the known cytomarkers (Krt14, Lgals7, Krt5, Dcn, Lum, Igfbp5, Cd31, Vwf, Stambpl1, Uqcrb, Cd3 and Acta2), biomarkers of the inflammatory response (Cd45/Ptprc, Adgre1, Ly6g, Il1b, Il4, Il13, Il22, Cxcl2 и Ccl17), as well as the proteins of extracellular matrix (type I and III collagens; precursors of COL5A1 and COLA1A; FTL, COL3A1, PGLS, CNN2, ANXA2, TPSAB1, COL12A1, precursors of APCS and ALB), and their encoding genes (FGF7, BAX, CCND1, MMP3, MMP9, CXCL1, -2, -5, -6 and -12; IL8, S100A7 and IL1A), those expression and co-location may potentially change the appearance and internal structure of damaged skin. We also describe how to choose biomarkers using the results genomic studies and their limitations. Moreover, we provide examples of how different groups of gene and protein biomarkers are used in experimental biology and clinical practice. According to the previously published data, well-known biomarkers verified on animal models, depend on their biological effects, let to characterize structural changes and changes in the composition of cells represented at the site of damage before and after the treatment. In addition, the published experimental and clinical data provide an opportunity to analyze the efficiency of new experimental approaches and compare them to each other.

Benign Laryngeal Lesions

Benign laryngeal lesions represent a diverse set of pathologies whose clinical presentation may range from no symptoms to dyspnea and/or dysphonia. Flexible fiberoptic laryngoscopy and videolaryngostroboscopy are important in distinguishingdifferent types of lesions, and management and treatment are dependent on the identification of these lesions, as they have different etiologies. Some lesions such as vocal fold nodules and polyps are primarily phonotraumatic and may benefit fromspeech therapy and vocal hygiene as initial approaches. Vocal fold cysts and benign tumors may benefit from microlaryngeal approaches, while capillary ectasias, polypoid corditis, laryngoceles, saccular cysts, and papilloma may benefit from laser therapy. Vocal fold granulomas may arise from various etiologies such as intubation, traumatic behaviors, or reflux. Polypoid corditis arises from smoking. This review is intended to provide an overview of the variety of lesions that encompass non-malignant laryngeal lesions that is both suitable for junior and senior residents. This review contains 12 figures, 5 tables, and 64 references Keywords: Benign laryngeal lesions, Laryngocele, Polyp, Cyst, Polypoid Corditis, Papilloma