Autonomic failure in diabetes

A 61-year-old man with no significant medical history developed fever, headache and mild shortness of breath. He tested positive for SARS-CoV-2 and self-isolated at home, not requiring hospital admission. One week after testing positive, he developed acute severe burning pain affecting his whole body, subsequently localised distally in the limbs. There was no ataxia or autonomic failure. Neurological examination was unremarkable. Electrophysiological tests were unremarkable. Skin biopsy, lumbar puncture, enhanced MRI of the brachial plexus and MRI of the neuroaxis were normal. His pain was inadequately controlled with pregabalin but improved while on a weaning regimen of steroids. This case highlights the variety of possible symptoms associated with SARS-CoV-2 infection.

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Adrenergic responsiveness of adipose tissue lipolysis in autonomic failure

Clinical Autonomic Research ◽

10.1007/s10286-004-0166-2 ◽

2004 ◽

Vol 14 (2) ◽

pp. 80-83 ◽

Cited By ~ 2

Author(s):

Jens Jordan ◽

Raffaello Furlan ◽

Jens Tank ◽

Simonetta Furlan ◽

Friedrich C. Luft ◽

...

Keyword(s):

Adipose Tissue ◽

Autonomic Failure ◽

Adipose Tissue Lipolysis

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Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease

Annals of Neurology ◽

10.1002/ana.24567 ◽

2015 ◽

Vol 79 (2) ◽

pp. 306-316 ◽

Cited By ~ 65

Author(s):

Vincenzo Donadio ◽

Alex Incensi ◽

Cristina Piccinini ◽

Pietro Cortelli ◽

Maria Pia Giannoccaro ◽

...

Keyword(s):

Parkinson Disease ◽

Autonomic Failure ◽

Pure Autonomic Failure

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Dyspnea as first sign of autonomic failure in postmortem confirmed multiple system atrophy

Movement Disorders ◽

10.1002/mds.23182 ◽

2010 ◽

Vol 25 (12) ◽

pp. 1997-1998 ◽

Cited By ~ 10

Author(s):

Wassilios G Meissner ◽

Anne Vital ◽

Imad Ghorayeb ◽

Dominique Guehl ◽

François Tison

Keyword(s):

Multiple System Atrophy ◽

Autonomic Failure

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Blood Pressure Variability in Health, Hypertension and Autonomic Failure

Clinical and Experimental Hypertension Part A Theory and Practice ◽

10.3109/10641968509073538 ◽

1985 ◽

Vol 7 (2-3) ◽

pp. 187-194 ◽

Cited By ~ 6

Author(s):

Stewart Mann ◽

Michael W. Millar Craig ◽

Douglas G. Altman ◽

E. B. Raftery ◽

S. N. Hunyor

Keyword(s):

Blood Pressure ◽

Blood Pressure Variability ◽

Autonomic Failure

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Comparison of the Renin Response to Dopamine and Noradrenaline in Normal Subjects and Patients with Autonomic Insufficiency

Clinical Science ◽

10.1042/cs0460481 ◽

1974 ◽

Vol 46 (4) ◽

pp. 481-488 ◽

Cited By ~ 3

Author(s):

C. S. Wilcox ◽

M. J. Aminoff ◽

A. B. Kurtz ◽

J. D. H. Slater

Keyword(s):

Autonomic Failure ◽

Sodium Intake ◽

Plasma Renin ◽

Normal Subjects ◽

Control Groups ◽

Autonomic Reflexes ◽

Fractional Increase ◽

The Mean ◽

Autonomic Insufficiency ◽

Stimulation Of

1. The effect on plasma renin activity (PRA) of dopamine and noradrenaline infusions was studied in three patients with Shy—Drager syndrome, three patients with Parkinson's disease and normal autonomic reflexes, and three healthy volunteers. The patients with the Shy—Drager syndrome had functional evidence of a peripheral lesion of the sympathetic nervous system and subnormal PRA on a controlled sodium intake. 2. In all subjects catecholamines were infused step-wise for 4 min until a 30% rise in systolic blood pressure occurred. 3. In each subject, PRA fell after noradrenaline but rose after dopamine. The mean fractional increase in PRA after dopamine was no less in the Shy—Drager patients than in the control groups. 4. The results suggest, first, that stimulation of dopamine receptors can release renin, and secondly, that inadequate renin stores cannot explain the low PRA found in our patients with autonomic failure.

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