Malabsorption

2018 ◽  
Author(s):  
Satish Keshav ◽  
Alexandra Kent
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Vitamin B12 ◽  
Coeliac Disease ◽  
Vitamin B12 Deficiency ◽  
Nutritional Deficiency ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
B12 Deficiency ◽  
Pancreatic Exocrine

Malabsorption is defined as a defect in the digestion and absorption of nutrients by the gastrointestinal tract. It can lead to a specific nutritional deficiency (‘selective’ malabsorption, such as vitamin B12 deficiency) or a general nutritional deficiency (global malabsorption, such as that due to diseases affecting the mucosa diffusely, such as Crohn’s disease). The commonest causes of malabsorption are coeliac disease and pancreatic exocrine insufficiency.

scholarly journals P148 Screening with holotranscobalamin is superior to serum B12 in identifying vitamin B12 deficiency in patients with Crohn's disease

2013 ◽  
Vol 7 ◽  
pp. S68
Author(s):  
M. Ward ◽  
V. Kariyawasam ◽  
A. Sobczynska-Malefora ◽  
A. Ajaegbu ◽  
J. Sanderson ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals PWE-093 Screening with Holotranscobalamin is Superior to Serum B12 in Identifying Vitamin B12 Deficiency in Patients with Crohn’S Disease

Gut ◽  
2013 ◽  
Vol 62 (Suppl 1) ◽  
pp. A168.2-A168
Author(s):  
M G Ward ◽  
V C Kariyawasam ◽  
P A Blaker ◽  
K V Patel ◽  
R M Goel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

S1050 Vitamin B12 Deficiency in Crohn's Disease: Oral Supplementation Is Effective

2009 ◽  
Vol 136 (5) ◽  
pp. A-177-A-178
Author(s):  
Santiago García López ◽  
Sonia Gallego Montañes ◽  
Fernando Gomollon ◽  
Marta Gracia Ruiz ◽  
Raquel Vicente Lidón
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Oral Supplementation ◽  
B12 Deficiency

scholarly journals Oral Symptoms Related to Vitamin B12 Deficiency in a Patient with Crohn's Disease

2017 ◽  
Vol 42 (1) ◽  
pp. 25-27
Author(s):  
Joo-Hee Lee ◽  
Youn-Jung Park ◽  
Jeong-Seung Kwon ◽  
Young-Gun Kim ◽  
Hyung-Joon Ahn
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
Oral Symptoms

An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease

2017 ◽  
Vol 35 (5) ◽  
pp. 463-471
Author(s):  
Shuzi Zheng ◽  
Chaoqun Wu ◽  
Wei Yang ◽  
Xuanping Xia ◽  
Xiuqing Lin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Mutant Allele ◽  
Vitamin B12 Deficiency ◽  
Folate Deficiency ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Folate And Vitamin B12 ◽  
Transcobalamin Ii

Objectives: The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (TCN2) polymorphisms and serum homocysteine, folate, and vitamin B12 levels. Methods:TCN2 (rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B12 levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively. Results: Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both p < 0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all p < 0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both p < 0.05). Compared to controls, average homocysteine level was enhanced in CD patients (p = 0.003), whereas average folate and vitamin B12 levels were reduced in CD patients (both p < 0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B12 deficiency was higher in CD patients than in controls (all p < 0.01). Both folate deficiency and vitamin B12 deficiency were independently related to risk of CD (both p < 0.01). Conclusion:TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with CD.

scholarly journals CROHN'S DISEASE WITH MACROCYTIC ANEMIA DUE TO VITAMIN B12 DEFICIENCY AFTER AN ILEOCECAL RESECTION-A REPORT OF A CASE-

2003 ◽  
Vol 64 (4) ◽  
pp. 932-935
Author(s):  
Atsuko FUKAZAWA ◽  
Toshio NAKAMURA ◽  
Keiji MARUYAMA ◽  
Sigeo MIYAZAKI ◽  
Satoshi NAKAMURA
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Macrocytic Anemia ◽  
Vitamin B12 Deficiency ◽  
Ileocecal Resection ◽  
B12 Deficiency

scholarly journals Isolated Malabsorption of Vitamin B12 Causing Megaloblastic Anemia and Hyperpigmentation in a Nigerian

Blood ◽  
1966 ◽  
Vol 28 (5) ◽  
pp. 770-775 ◽  
Author(s):  
E. J. WATSON-WILLIAMS ◽  
A. F. FLEMING
Keyword(s):  
Gastrointestinal Tract ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Megaloblastic Anemia ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

Abstract A Nigerian patient is described with megaloblastic anemia due to vitamin B12 deficiency. The deficiency resulted from malabsorption of the vitamin, but no other abnormal functioning of the gastrointestinal tract could be demonstrated. The patient did not have addisonian pernicious anemia. He had remarkable hyperpigmentation of the skin, especially of the palms of the hands. What is known of possible connections between megaloblastic anemias and melanin metabolism cannot explain this hyperpigmentation.

scholarly journals Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease

Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 308 ◽  
Author(s):  
Fernando Gomollón ◽  
Carla Gargallo ◽  
Jose Muñoz ◽  
Raquel Vicente ◽  
Alberto Lue ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

Bioavailability of food iron-(59Fe), vitamin B12-(60Co) and protein bound selenomethionine-(75Se) in pancreatic exocrine insufficiency due to cystic fibrosis

1977 ◽  
Vol 55 (12) ◽  
pp. 595-601 ◽  
Author(s):  
H. C. Heinrich ◽  
E. E. Gabbe ◽  
H. Bartels ◽  
K. H. Oppitz ◽  
Ch Bender-G�tze ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin B12 ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
Pancreatic Exocrine
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