Posterior urethral valves

Author(s):  
Michiel F. Schreuder

Posterior urethral valves is the most common congenital cause of lower urinary tract obstruction in males, and a common cause (15–17%) for end-stage renal disease in childhood. Most commonly, posterior urethral valves is suspected on basis of a screening antenatal ultrasound. Ultrasound will not detect posterior urethral valves itself, but recognizes the consequences of lower urinary tract obstruction with a dilated thick-walled bladder and dilation of the prostatic portion of the urethra. After birth, urine drainage has to be secured by placement of a bladder catheter, and imaging is needed to confirm the presence of the urethral valves and estimate the degree of damage to the kidney. Consequences of posterior urethral valves depend on the degree of renal dysplasia and bladder dysfunction. Prevention or minimization of such consequences by intrauterine urine drainage has not definitively shown a benefit of early vesico-amniotic shunting.

2016 ◽  
Vol 60 (2) ◽  
Author(s):  
Jacek Materny ◽  
Elżbieta Gawrych ◽  
Anna Walecka

We present a rare association of anterior and posterior urethral valves. A 5 days­‍‑old boy was admitted because of clinical presenation of lower urinary tract obstruction. A renal ultrasound and voiding cysto­‍‑urethrography revealed obstructive pathology in anterior urethra. On endoscopy an association of anterior and posterior urethral valves was recognized, and the valves were incised. Follow­‍‑up demonstrated improvement of preoperative signs. We try to recognize an association of anterior and posterior urethral valves in radiological examinations.


2018 ◽  
Vol 14 (4) ◽  
pp. 320.e1-320.e6 ◽  
Author(s):  
Paulo Renato Marcelo Moscardi ◽  
Chryso P. Katsoufis ◽  
Mona Jahromi ◽  
Ruben Blachman-Braun ◽  
Marissa J. DeFreitas ◽  
...  

Genes ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1449
Author(s):  
Luca M. Schierbaum ◽  
Sophia Schneider ◽  
Stefan Herms ◽  
Sugirthan Sivalingam ◽  
Julia Fabian ◽  
...  

Lower urinary tract obstruction (LUTO) is, in most cases, caused by anatomical blockage of the bladder outlet. The most common form are posterior urethral valves (PUVs), a male-limited phenotype. Here, we surveyed the genome of 155 LUTO patients to identify disease-causing CNVs. Raw intensity data were collected for CNVs detected in LUTO patients and 4.392 healthy controls using CNVPartition, QuantiSNP and PennCNV. Overlapping CNVs between patients and controls were discarded. Additional filtering implicated CNV frequency in the database of genomic variants, gene content and final visual inspection detecting 37 ultra-rare CNVs. After, prioritization qPCR analysis confirmed 3 microduplications, all detected in PUV patients. One microduplication (5q23.2) occurred de novo in the two remaining microduplications found on chromosome 1p36.21 and 10q23.31. Parental DNA was not available for segregation analysis. All three duplications comprised 11 coding genes: four human specific lncRNA and one microRNA. Three coding genes (FBLIM1, SLC16A12, SNCAIP) and the microRNA MIR107 have previously been shown to be expressed in the developing urinary tract of mouse embryos. We propose that duplications, rare or de novo, contribute to PUV formation, a male-limited phenotype.


1970 ◽  
Vol 31 (3) ◽  
pp. 61-62
Author(s):  
N B Thapa ◽  
Y Dwa ◽  
S Gurung ◽  
R Baral

Urethral atresia is one of the rare congenital anomaly of urogenital tract. In this case report, uretheral atresia diagnosed antenatally by ultrasonography (USG) at 24-25 weeks of gestation is presented. USG findings were confirmed by postmortem examination of the fetus. Key words: Lower urinary tract obstruction, posterior urethral valves, ultrasonography, urethral atresia, DOI: 10.3126/joim.v31i3.3001 Journal of Institute of Medicine, December, 2009; 31(3) 61-62


2018 ◽  
Author(s):  
O Graupner ◽  
C Enzensberger ◽  
M Götte ◽  
A Wolter ◽  
V Müller ◽  
...  

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