Two Cases of Fetal Lower Urinary Tract Obstruction (LUTO) with Similar Presentations Before But Contrasting Outcomes After Fetoscopic Laser Fulguration of Posterior Urethral Valves

2021 ◽  
Author(s):  
Jasmine Lall ◽  
Mohan Abraham ◽  
Sarala Sreedhar ◽  
Sudha Kishore ◽  
Sushmita Namdeo ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Posterior Urethral Valves ◽  
Urethral Valves ◽  
Lower Urinary Tract Obstruction ◽  
Lower Urinary

Posterior urethral valves

2015 ◽  
Author(s):  
Michiel F. Schreuder
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Renal Dysplasia ◽  
Posterior Urethral Valves ◽  
Urethral Valves ◽  
Lower Urinary Tract Obstruction ◽  
Stage Renal Disease ◽  
End Stage ◽  
Lower Urinary

Posterior urethral valves is the most common congenital cause of lower urinary tract obstruction in males, and a common cause (15–17%) for end-stage renal disease in childhood. Most commonly, posterior urethral valves is suspected on basis of a screening antenatal ultrasound. Ultrasound will not detect posterior urethral valves itself, but recognizes the consequences of lower urinary tract obstruction with a dilated thick-walled bladder and dilation of the prostatic portion of the urethra. After birth, urine drainage has to be secured by placement of a bladder catheter, and imaging is needed to confirm the presence of the urethral valves and estimate the degree of damage to the kidney. Consequences of posterior urethral valves depend on the degree of renal dysplasia and bladder dysfunction. Prevention or minimization of such consequences by intrauterine urine drainage has not definitively shown a benefit of early vesico-amniotic shunting.

scholarly journals WSPÓŁISTNIENIE ZASTAWKI CEWKI PRZEDNIEJ I TYLNEJ U NOWORODKA. CZY ROZPOZNANIE KOINCYDENCJI WAD NA PODSTAWIE OBJAWÓW KLINICZNYCH I BADAŃ OBRAZOWYCH JEST MOŻLIWE?

2016 ◽  
Vol 60 (2) ◽  
Author(s):  
Jacek Materny ◽  
Elżbieta Gawrych ◽  
Anna Walecka
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Posterior Urethral Valves ◽  
Renal Ultrasound ◽  
Urethral Valves ◽  
Rare Association ◽  
Lower Urinary Tract Obstruction ◽  
Radiological Examinations ◽  
Lower Urinary

We present a rare association of anterior and posterior urethral valves. A 5 days­‍‑old boy was admitted because of clinical presenation of lower urinary tract obstruction. A renal ultrasound and voiding cysto­‍‑urethrography revealed obstructive pathology in anterior urethra. On endoscopy an association of anterior and posterior urethral valves was recognized, and the valves were incised. Follow­‍‑up demonstrated improvement of preoperative signs. We try to recognize an association of anterior and posterior urethral valves in radiological examinations.

scholarly journals Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO)

Genes ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1449
Author(s):  
Luca M. Schierbaum ◽  
Sophia Schneider ◽  
Stefan Herms ◽  
Sugirthan Sivalingam ◽  
Julia Fabian ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
De Novo ◽  
Urinary Tract Obstruction ◽  
Posterior Urethral Valves ◽  
Rare Cnvs ◽  
Genome Wide ◽  
Lower Urinary Tract Obstruction ◽  
Human Specific ◽  
Lower Urinary

Lower urinary tract obstruction (LUTO) is, in most cases, caused by anatomical blockage of the bladder outlet. The most common form are posterior urethral valves (PUVs), a male-limited phenotype. Here, we surveyed the genome of 155 LUTO patients to identify disease-causing CNVs. Raw intensity data were collected for CNVs detected in LUTO patients and 4.392 healthy controls using CNVPartition, QuantiSNP and PennCNV. Overlapping CNVs between patients and controls were discarded. Additional filtering implicated CNV frequency in the database of genomic variants, gene content and final visual inspection detecting 37 ultra-rare CNVs. After, prioritization qPCR analysis confirmed 3 microduplications, all detected in PUV patients. One microduplication (5q23.2) occurred de novo in the two remaining microduplications found on chromosome 1p36.21 and 10q23.31. Parental DNA was not available for segregation analysis. All three duplications comprised 11 coding genes: four human specific lncRNA and one microRNA. Three coding genes (FBLIM1, SLC16A12, SNCAIP) and the microRNA MIR107 have previously been shown to be expressed in the developing urinary tract of mouse embryos. We propose that duplications, rare or de novo, contribute to PUV formation, a male-limited phenotype.

scholarly journals Prenatal ultrasonographic diagnosis of urethral atresia

1970 ◽  
Vol 31 (3) ◽  
pp. 61-62
Author(s):  
N B Thapa ◽  
Y Dwa ◽  
S Gurung ◽  
R Baral
Keyword(s):  
Lower Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Posterior Urethral Valves ◽  
Postmortem Examination ◽  
Institute Of Medicine ◽  
Rare Congenital Anomaly ◽  
Urethral Valves ◽  
Ultrasonographic Diagnosis ◽  
Lower Urinary Tract Obstruction ◽  
Lower Urinary

Urethral atresia is one of the rare congenital anomaly of urogenital tract. In this case report, uretheral atresia diagnosed antenatally by ultrasonography (USG) at 24-25 weeks of gestation is presented. USG findings were confirmed by postmortem examination of the fetus. Key words: Lower urinary tract obstruction, posterior urethral valves, ultrasonography, urethral atresia, DOI: 10.3126/joim.v31i3.3001 Journal of Institute of Medicine, December, 2009; 31(3) 61-62

Myokardiale Funktion bei Feten mit Lower Urinary Tract Obstruction

2018 ◽  
Author(s):  
O Graupner ◽  
C Enzensberger ◽  
M Götte ◽  
A Wolter ◽  
V Müller ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Lower Urinary Tract Obstruction ◽  
Lower Urinary

Evaluation of the Fetal Therapy Evidence in Lower Urinary Tract Obstruction: Would an ERAS Guideline Improve Outcomes?

2021 ◽  
pp. 1-13
Author(s):  
R. Douglas Wilson ◽  
Gregg Nelson
Keyword(s):  
Quality Improvement ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Fetal Surgery ◽  
Fetal Therapy ◽  
Lower Urinary Tract Obstruction ◽  
Evidenced Based ◽  
Process Elements ◽  
Lower Urinary

<b><i>Background:</i></b> Pregnancies that are prenatally identified to have fetal anomalies are complex and require expert multidisciplinary care. As many conditions can impact the fetus prenatally and require intervention, an enhanced recovery after surgery (ERAS) for lower urinary tract obstruction (LUTO) is being evaluated to determine the level of evidenced-based data available. <b><i>Problem:</i></b> The percutaneous ultrasound-guided fetal surgery procedure for bladder neck obstruction is the focus for elements of preoperative counseling, intraoperative procedure/risk complications, and postoperative management. <b><i>Methods:</i></b> A quality improvement review Squire 2.0 (2000–2020) was undertaken for the percutaneous LUTO fetal surgery shunting (lower urinary tract obstruction), process and procedure which require 2 process pathways, one to evaluate the fetal candidate and a second to treat. This structured review is focused on identifying the process elements to allow the determination of the number of evidenced-based elements that would allow for audit and measurement of the clinical element variance for comparative feedback to the individual surgical provider or surgery center. <b><i>Interventions:</i></b> Titles and abstracts were screened to identify potentially relevant articles with priority given to meta-analyses, systematic reviews, randomized controlled studies, nonrandomized controlled studies, reviews, and case series. <b><i>Results:</i></b> A series of potential clinical elements for the diagnostic fetal evaluation and for the 3 protocol areas of surgical care for the procedures (pre-, intra-, and postoperative care) are identified using an ERAS-like process. <b><i>Conclusions:</i></b> The identified clinical elements have the potential for ERAS-LUTO fetal therapy guideline. Multidisciplinary collaboration (surgeon, anesthesia, nursing, imaging, and laboratory) is required for ERAS quality improvement in the pre-, intra-, and postoperative processes. Process elements in each of the operative areas can be audited, evaluated, compared, and modified/improved.

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