Duplication and Divergence of Two Distinct Pancreatic Ribonuclease Genes in Leaf-Eating African and Asian Colobine Monkeys

2006 ◽  
Vol 23 (9) ◽  
pp. 1817-1817
Keyword(s):  
Pancreatic Ribonuclease ◽  
Colobine Monkeys

scholarly journals Duplication and Divergence of 2 Distinct Pancreatic Ribonuclease Genes in Leaf-Eating African and Asian Colobine Monkeys

2006 ◽  
Vol 23 (8) ◽  
pp. 1465-1479 ◽  
Author(s):  
John E. Schienman ◽  
Robert A. Holt ◽  
Marcy R. Auerbach ◽  
Caro-Beth Stewart
Keyword(s):  
Pancreatic Ribonuclease ◽  
Colobine Monkeys

scholarly journals Duplication and parallel evolution of the pancreatic ribonuclease gene (RNASE1) in folivorous non-colobine primates, the howler monkeys (Alouatta spp.)

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mareike C. Janiak ◽  
Andrew S. Burrell ◽  
Joseph D. Orkin ◽  
Todd R. Disotell
Keyword(s):  
Digestive Enzyme ◽  
Parallel Evolution ◽  
Immune Defense ◽  
Howler Monkey ◽  
Howler Monkeys ◽  
Pancreatic Ribonuclease ◽  
Colobine Monkeys ◽  
Enzyme Adaptation ◽  
The Common ◽  
Multiple Amino Acid

AbstractIn foregut-fermenting mammals (e.g., colobine monkeys, artiodactyl ruminants) the enzymes pancreatic ribonuclease (RNASE1) and lysozyme C (LYZ), originally involved in immune defense, have evolved new digestive functions. Howler monkeys are folivorous non-colobine primates that lack the multi-chambered stomachs of colobines and instead digest leaves using fermentation in the caeco-colic region. We present data on the RNASE1 and LYZ genes of four species of howler monkey (Alouatta spp.). We find that howler monkey LYZ is conserved and does not share the substitutions found in colobine and cow sequences, whereas RNASE1 was duplicated in the common ancestor of A. palliata, A. seniculus, A. sara, and A. pigra. While the parent gene (RNASE1) is conserved, the daughter gene (RNASE1B) has multiple amino acid substitutions that are parallel to those found in RNASE1B genes of colobines. The duplicated RNase in Alouatta has biochemical changes similar to those in colobines, suggesting a novel, possibly digestive function. These findings suggest that pancreatic ribonuclease has, in parallel, evolved a new role for digesting the products of microbial fermentation in both foregut- and hindgut-fermenting folivorous primates. This may be a vital digestive enzyme adaptation allowing howler monkeys to survive on leaves during periods of low fruit availability.

scholarly journals On the Preparation of Bovine Pancreatic Ribonuclease A

1963 ◽  
Vol 238 (2) ◽  
pp. 618-621 ◽  
Author(s):  
Arthur M. Crestfield ◽  
William H. Stein ◽  
Stanford Moore
Keyword(s):  
Ribonuclease A ◽  
Pancreatic Ribonuclease ◽  
Pancreatic Ribonuclease A

scholarly journals The Amino Acid Sequence of Ovine Pancreatic Ribonuclease A

1973 ◽  
Vol 248 (22) ◽  
pp. 7833-7837
Author(s):  
Ryoko Kobayashi ◽  
C.H.W. Hirs ◽  
With the technical assistance of Marie Hagenhuber
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Ribonuclease A ◽  
Pancreatic Ribonuclease ◽  
Pancreatic Ribonuclease A

scholarly journals Folding, Quality Control, and Secretion of Pancreatic Ribonuclease in Live Cells

2010 ◽  
Vol 286 (7) ◽  
pp. 5813-5822 ◽  
Author(s):  
Roger Geiger ◽  
Matthias Gautschi ◽  
Friederike Thor ◽  
Arnold Hayer ◽  
Ari Helenius
Keyword(s):  
Quality Control ◽  
Live Cells ◽  
Pancreatic Ribonuclease
Sign in / Sign up

Export Citation Format

Share Document