scholarly journals A proposal for a novel rationale for critical effect size in dose–response analysis based on a multi-endpointin vivostudy with methyl methanesulfonate

Mutagenesis ◽  
2015 ◽  
Vol 31 (3) ◽  
pp. 239-253 ◽  
Author(s):  
Andreas Zeller ◽  
Leilei Tang ◽  
Stephen D. Dertinger ◽  
Juergen Funk ◽  
Gonzalo Duran-Pacheco ◽  
...  
Keyword(s):  
Dose Response ◽  
Effect Size ◽  
Methyl Methanesulfonate ◽  
Response Analysis ◽  
Critical Effect ◽  
Critical Effect Size

scholarly journals Derivation of the critical effect size/benchmark response for the dose-response analysis of the uptake of radioactive iodine in the human thyroid

2016 ◽  
Vol 257 ◽  
pp. 38-43 ◽  
Author(s):  
Peter J.J.M. Weterings ◽  
Christine Loftus ◽  
Thomas A. Lewandowski
Keyword(s):  
Dose Response ◽  
Effect Size ◽  
Radioactive Iodine ◽  
Human Thyroid ◽  
Response Analysis ◽  
Critical Effect ◽  
Critical Effect Size

scholarly journals A REVIEW OF POTENTIAL METHODS OF DETERMINING CRITICAL EFFECT SIZE FOR DESIGNING ENVIRONMENTAL MONITORING PROGRAMS

2009 ◽  
Vol 28 (7) ◽  
pp. 1361 ◽  
Author(s):  
Kelly R. Munkittrick ◽  
Collin J. Arens ◽  
Richard B. Lowell ◽  
Greg P. Kaminski
Keyword(s):  
Environmental Monitoring ◽  
Effect Size ◽  
Critical Effect ◽  
Monitoring Programs ◽  
Potential Methods ◽  
Critical Effect Size

Derivation of the minimal magnitude of the Critical Effect Size for continuous toxicological parameters from within-animal variation in control group data

2009 ◽  
Vol 55 (2) ◽  
pp. 139-150 ◽  
Author(s):  
H.E. Buist ◽  
G. Frhr. von Bölcsházy ◽  
M. Dammann ◽  
J. Telman ◽  
M.A.J. Rennen
Keyword(s):  
Effect Size ◽  
Control Group ◽  
Critical Effect ◽  
Group Data ◽  
Critical Effect Size

Within-animal variation as a minimal critical effect size for continuous toxicological parameters applicable in the Benchmark dose approach

2006 ◽  
Vol 164 ◽  
pp. S146-S147
Author(s):  
Susan Dekkers ◽  
Jan Telman ◽  
Monique Rennen ◽  
Marko Appel ◽  
Harrie Buist ◽  
...  
Keyword(s):  
Effect Size ◽  
Benchmark Dose ◽  
Critical Effect ◽  
Benchmark Dose Approach ◽  
Critical Effect Size

Within-Animal Variation as an Indication of the Minimal Magnitude of the Critical Effect Size for Continuous Toxicological Parameters Applicable in the Benchmark Dose Approach

Risk Analysis ◽  
2006 ◽  
Vol 26 (4) ◽  
pp. 867-880 ◽  
Author(s):  
Susan Dekkers ◽  
Jan Telman ◽  
Monique A. J. Rennen ◽  
Marco J. Appel ◽  
Cees de Heer
Keyword(s):  
Effect Size ◽  
Benchmark Dose ◽  
Critical Effect ◽  
Benchmark Dose Approach ◽  
Critical Effect Size

A Dose-Response Analysis of Nicotine Sensitization in Adolescent Rats D2-Primed as Neonates

2010 ◽  
Author(s):  
Elizabeth A. Hanchak ◽  
Meredith L. Smith ◽  
Jessie J. Smith ◽  
Marla K. Perna ◽  
Russell W. Brown
Keyword(s):  
Dose Response ◽  
Response Analysis ◽  
Adolescent Rats

ENCORE: A weight-based exacerbation dose response analysis of mepolizumab in severe asthma with eosinophilic phenotype

Pneumologie ◽  
2017 ◽  
Vol 71 (S 01) ◽  
pp. S1-S125
Author(s):  
I Pouliquen ◽  
D Austin ◽  
N Gunsoy ◽  
SW Yancey
Keyword(s):  
Severe Asthma ◽  
Dose Response ◽  
Response Analysis

scholarly journals Sleep duration and all-cause mortality in the elderly in China: a population-based cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yanfeng Ren ◽  
Maohua Miao ◽  
Wei Yuan ◽  
Jiangwei Sun
Keyword(s):  
Cohort Study ◽  
Sleep Duration ◽  
Dose Response ◽  
Cox Regression ◽  
Oldest Old ◽  
The Elderly ◽  
Response Analysis ◽  
Short Sleep Duration ◽  
All Cause Mortality

Abstract Background Although a U-shaped association between sleep duration and all-cause mortality has been found in general population, its association in the elderly adults, especially in the oldest-old, is rarely explored. Methods In present cohort study, we prospectively explore the association between sleep duration and all-cause mortality among 15,092 participants enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2019. Sleep duration and death information was collected by using structured questionnaires. Cox regression model with sleep duration as a time-varying exposure was performed to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). The dose-response association between them was explored via a restricted cubic spline function. Results During an average follow-up of 4.51 (standard deviation, SD: 3.62) years, 10,768 participants died during the follow-up period. The mean (SD) age of the participants was 89.26 (11.56) years old. Compared to individuals with moderate sleep duration (7–8 hours), individuals with long sleep duration (> 8 hours) had a significantly higher risk of all-cause mortality (HR: 1.13, 95%CI: 1.09–1.18), but not among individuals with short sleep duration (≤ 6 hours) (HR: 1.02, 95%CI: 0.96–1.09). Similar results were observed in subgroup analyses based on age and gender. In the dose-response analysis, a J-shaped association was observed. Conclusions Sleep duration was associated with all-cause mortality in a J-shaped pattern in the elderly population in China.

Maternal care alterations induced by repeated ethanol leads to heightened consumption of the drug and motor impairment during adolescence: A dose–response analysis

2011 ◽  
Vol 103 (5) ◽  
pp. 477-486 ◽  
Author(s):  
Luciano F. Ponce ◽  
Ricardo Marcos Pautassi ◽  
Norman E. Spear ◽  
Juan C. Molina
Keyword(s):  
Dose Response ◽  
Maternal Care ◽  
Motor Impairment ◽  
Response Analysis
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