scholarly journals Randomized controlled trial to evaluate the impact of aerobic exercise on visceral fat in overweight chronic kidney disease patients

2014 ◽  
Vol 29 (4) ◽  
pp. 857-864 ◽  
Author(s):  
F. Baria ◽  
M. A. Kamimura ◽  
D. T. Aoike ◽  
A. Ammirati ◽  
M. Leister Rocha ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Randomized Controlled Trial ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Visceral Fat ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
The Impact

Dyslipidemia in chronic kidney disease: randomized controlled trial of colestilan versus simvastatin in dialysis patients

2014 ◽  
Vol 82 (09) ◽  
pp. 163-172 ◽  
Author(s):  
Chistoph Wanner ◽  
Winfried März ◽  
Andrei Varushchanka ◽  
Natallia Apanasovich ◽  
Nickolay Dosta ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Randomized Controlled Trial ◽  
Kidney Disease ◽  
Controlled Trial ◽  
Dialysis Patients ◽  
Randomized Controlled

scholarly journals Effects of aerobic exercise on vascular function in nondialysis chronic kidney disease: a randomized controlled trial

2019 ◽  
Vol 316 (5) ◽  
pp. F898-F905 ◽  
Author(s):  
Danielle L. Kirkman ◽  
Meghan G. Ramick ◽  
Bryce J. Muth ◽  
Joseph M. Stock ◽  
Ryan T. Pohlig ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Vascular Function ◽  
Controlled Trial ◽  
Ringer Solution ◽  
Microvascular Function ◽  
Flow Mediated Dilation ◽  
Randomized Controlled ◽  
Artery Flow

Endothelial dysfunction and arterial stiffness are nontraditional risk factors of chronic kidney disease (CKD)-related cardiovascular disease (CVD) that could be targeted with exercise. This study investigated the effect of moderate to vigorous aerobic exercise on vascular function in nondialysis CKD. In this randomized, controlled trial, 36 nondialysis patients with CKD (means ± SE, age: 58 ± 2 yr, estimated glomerular filtration rate: 44 ± 2 ml·min−1·1.73 m−2) were allocated to an exercise training (EXT) or control (CON) arm. The EXT group performed 3 × 45 min of supervised exercise per week at 60–85% heart rate reserve for 12 wk, whereas the CON group received routine care. Outcomes were assessed at 0 and 12 wk. The primary outcome, microvascular function, was assessed via cutaneous vasodilation during local heating measured by laser-Doppler flowmetry coupled with microdialysis. Participants were instrumented with two microdialysis fibers for the delivery of 1) Ringer solution and 2) the superoxide scavenger tempol. Conduit artery function was assessed via brachial artery flow-mediated dilation. Aortic pressure waveforms and pulse wave velocity were acquired with tonometry and oscillometry. Microvascular function improved after EXT ( week 0 vs . week 12, EXT: 87 ± 2% vs. 91 ± 2% and CON: 86 ± 2% vs. 84 ± 3%, P = 0.03). At baseline, pharmacological delivery of tempol improved microvascular function (Ringer solution vs. tempol: 86 ± 1% vs. 90 ± 1%, P = 0.02) but was no longer effective after EXT (91 ± 2% vs. 87 ± 1%, P = 0.2), suggesting that an improved redox balance plays a role in EXT-related improvements. Brachial artery flow-mediated dilation was maintained after EXT (EXT: 2.6 ± 0.4% vs. 3.8 ± 0.8% and CON: 3.5 ± 0.6% vs. 2.3 ± 0.4%, P = 0.02). Central arterial hemodynamics and arterial stiffness were unchanged after EXT. Aerobic exercise improved microvascular function and maintained conduit artery function and should be considered as an adjunct therapy to reduce CVD risk in CKD.

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