SP826TREATMENT OF HEPATITIS C VIRUS IN RENAL TRANSPLANT PATIENTS. RESULTS FROM A SINGLE CENTRE WITH THE USE OF DIRECT ANTIVIRAL AGENTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii420-iii420
Author(s):  
Jordi Soler Majoral ◽  
Laura Cañas Solé ◽  
Mercè Ardèvol ◽  
Mònica Pérez Mir ◽  
Francisco-Javier Juega Mariño ◽  
...  
2020 ◽  
Vol 4 (2) ◽  
pp. 29-33
Author(s):  
Maurizio Salvadori ◽  
Aris Tsalouchos

Renal transplantation in patients affected by hepatitis C virus (HCV) infection has been a serious problem becauseof the use of immunosuppres-sants. HCV virus may be more aggressive in both the liver and the kidney. Several posttransplantation pathologies are known to be ascribed to the HCV virus.Virus eradication has been historically attempted with interferon (IFN) and ribavirin with poor results. In addition, IFN given posttransplan-tation may cause severe acute rejection.The introduction of direct antiviral agents (DAA) has revolutionized the treatment, and now it is possible to treat renal transplant patients with these agents leading to a HCV-free status in 3 months without the use of IFN.The major problem caused by these agents is their interference with the immunosuppressive agents.The pharmacokinetics of DAA and immunosuppressants often meet the same metabolic pathways and use the same cytochromes or proteic complexes. In some cases, this may lead to high or low immunosuppressant levels with the risk of rejection. In other cases, the DAAs are inter-ested and they may be increase or decrease in a dangerous way. Therefore a strict monitoring is always recommended.


1992 ◽  
Vol 5 ◽  
pp. S51-S53
Author(s):  
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Ch. Stathakis ◽  
H. Papastathi ◽  
I. Vafiadi ◽  
D. Goumenos ◽  
...  

1998 ◽  
Vol 30 (4) ◽  
pp. 1264-1265 ◽  
Author(s):  
C Manzanares ◽  
M Moreno ◽  
F Castellanos ◽  
A Cubas ◽  
J.C Herrero ◽  
...  

1999 ◽  
Vol 67 (4) ◽  
pp. 556-560 ◽  
Author(s):  
Lionel Rostaing ◽  
Jacques Izopet ◽  
Catherine Arnaud ◽  
Jean-Marc Cisterne ◽  
Laurent Alric ◽  
...  

2004 ◽  
Vol 36 (4) ◽  
pp. 886-888 ◽  
Author(s):  
Y.A.S Sens ◽  
V.D.S.T Silva ◽  
P Malafronte ◽  
J.F Souza ◽  
L.A Miorin ◽  
...  

1997 ◽  
Vol 17 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Lionel Rostaing ◽  
Jacques Izopet ◽  
Jean-Marc Cisterne ◽  
Josette Icart ◽  
Marie-Hélène Chabannier ◽  
...  

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