scholarly journals FP098REDD1/AUTOPHAGY PATHWAY PROMOTES THROMBOINFLAMMATION AND FIBROSIS IN HUMAN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) BY THE RELEASE OF NEUTROPHIL EXTRACELLULAR TRAPS (NETS)

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i80-i80
Author(s):  
Eleni Frangou ◽  
Akrivi Chrysanthopoulou ◽  
Konstantinos Kambas ◽  
Alexandros Mitsios ◽  
Stella Arelaki ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophil Extracellular Traps ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Extracellular Traps ◽  
Autophagy Pathway

scholarly journals The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Meng Jiang ◽  
Nan Shen ◽  
Haibo Zhou ◽  
You Wang ◽  
Sihan Lin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nk Cells ◽  
Lupus Erythematosus ◽  
Neutrophil Extracellular Traps ◽  
Clinical Samples ◽  
Systemic Lupus ◽  
Extracellular Traps ◽  
Fetal Birth Weight ◽  
Immunological Disorder ◽  
Adverse Pregnancy

AbstractDespite the advances made in the management of pregnancies in women with systemic lupus erythematosus (SLE), the rate of adverse pregnancy outcomes is still higher than that in the general population. In the last few years, neutrophil extracellular traps (NETs) were proven to be detrimental in both autoimmune diseases and placental injury. We investigated whether NETs could be detected in the placentas of pregnant individuals with SLE and explored the relationship between NETs and decidual natural killer cells (dNKs), which comprise the majority of immune cells at the maternal–fetal interface, using clinical samples and animal models. In this study, we found that the infiltration of NETs and dNKs, especially CD56+CD16+ NK cells, was significantly increased in pregnant individuals with SLE with placental insufficiency. In the murine models of SLE, the number of dNKs was significantly decreased due to the decreased formation of NETs affected by Ly6G. Moreover, the histopathological placental injury was reduced, with a remarkable increase in fetal birth weight. This study shows that NETs may contribute to immunological disorder in the placenta and the pathological changes in pregnancies with SLE, which provides a research basis for further explorations of the mechanism of SLE in placental impairment.

Neutrophil extracellular traps-associated markers are elevated in patients with systemic lupus erythematosus

2019 ◽  
Vol 39 (11) ◽  
pp. 1849-1857 ◽  
Author(s):  
Ivica Jeremic ◽  
Olivera Djuric ◽  
Milos Nikolic ◽  
Marina Vlajnic ◽  
Aleksandra Nikolic ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophil Extracellular Traps ◽  
Systemic Lupus ◽  
Extracellular Traps

scholarly journals SP043AUTOPHAGY-MEDIATED DELIVERY OF TISSUE FACTOR ON NEUTROPHIL EXTRACELLULAR TRAPS BY MAY PROMOTE KIDNEY INJURY IN SYSTEMIC LUPUS ERYTHEMATOSUS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii394-iii395
Author(s):  
Eleni A Frangou ◽  
Konstantinos Kambas ◽  
George Bertsias ◽  
Panayotis Verginis ◽  
Konstantinos Ritis ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Tissue Factor ◽  
Lupus Erythematosus ◽  
Kidney Injury ◽  
Neutrophil Extracellular Traps ◽  
Systemic Lupus ◽  
Extracellular Traps

scholarly journals Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

2013 ◽  
Vol 15 (4) ◽  
pp. R84 ◽  
Author(s):  
Jonatan Leffler ◽  
Birgitta Gullstrand ◽  
Andreas Jönsen ◽  
Jan-Åke Nilsson ◽  
Myriam Martin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Neutrophil Extracellular Traps ◽  
Systemic Lupus ◽  
Extracellular Traps
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