Characteristics Relating to ovarian Cancer Risk: Collaborative Analysis of 12 US case-Control Studies

AbstractSedentary behaviour is an emerging risk factor for several site-specific cancers. Ovarian cancers are often detected at late disease stages and the role of sedentary behaviour as a modifiable risk factor potentially contributing to ovarian cancer risk has not been extensively examined. We systematically searched relevant databases from inception to February 2020 for eligible publications dealing with sedentary behaviour in relation to ovarian cancer risk. We conducted a systematic review and meta-analysis, calculating summary relative risks (RR) and 95% confidence intervals (CI) using a random-effects model. We calculated the E-Value, a sensitivity analysis for unmeasured confounding. We tested for publication bias and heterogeneity. Seven studies (three prospective cohort studies and four case–control studies) including 2060 ovarian cancer cases were analysed. Comparing highest versus lowest levels of sedentary behaviour, the data indicated a statistically significant increase in the risk of ovarian cancer in relation to prolonged sitting time (RR = 1.29, 95% CI = 1.07–1.57). Sub-analyses of prospective cohort studies (RR = 1.33, 95% CI = 0.92–1.93) and case–control studies (RR = 1.28, 95% CI = 0.98–1.68) showed statistically non-significant results. Sensitivity analysis showed that an unmeasured confounder would need to be related to sedentary behaviour and ovarian cancer with a RR of 1.90 to fully explain away the observed RR of 1.29. Our analyses showed a statistically significant positive association between sedentary behaviour and ovarian cancer risk.

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Meat, fish, and ovarian cancer risk: results from 2 Australian case-control studies, a systematic review, and meta-analysis

American Journal of Clinical Nutrition ◽

10.3945/ajcn.2009.28415 ◽

2010 ◽

Vol 91 (6) ◽

pp. 1752-1763 ◽

Cited By ~ 42

Author(s):

Fariba Kolahdooz ◽

Jolieke C van der Pols ◽

Christopher J Bain ◽

Geoffrey C Marks ◽

Maria Celia Hughes ◽

...

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Case Control ◽

Ovarian Cancer Risk ◽

Case Control Studies ◽

Australian Case

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Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000463 ◽

2015 ◽

Vol 25 (6) ◽

pp. 961-967 ◽

Cited By ~ 3

Author(s):

Lijie Wang ◽

Beihua Kong

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Matrix Metalloproteinase ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Gene Promoter ◽

Case Control ◽

Ovarian Cancer Risk ◽

Case Control Studies ◽

Matrix Metalloproteinase 1

ObjectiveStudies investigating the association betweenmatrix metalloproteinase-1(MMP1) gene promoter 1607–base pair (bp) polymorphism and ovarian cancer risk have yielded conflicting results.MethodsWe therefore carried out a meta-analysis of 754 ovarian cancer cases and 1184 controls from 5 published case-control studies. The strength of the association betweenMMP11607-bp polymorphism and ovarian cancer susceptibility was calculated using pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).ResultsThe results suggest that no statistically significant associations exist betweenMMP11607-bp polymorphisms and ovarian cancer risk in all 4 genetic models (2G2G vs 1G1G: OR, 1.08; 95% CI, 0.81–1.43;P= 0.23; 1G2G vs 1G1G: OR, 1.06; 95% CI, 0.82–1.36;P= 0.15; 1G2G + 2G2G vs 1G1G: OR, 1.05; 95% CI, 0.83–1.34;P= 0.16; 2G2G vs 1G1G + 1G2G: OR, 0.98; 95% CI, 0.80–1.20;P= 0.84).ConclusionsIn summary, this meta-analysis showed that theMMP11607-bp polymorphism is not associated with ovarian cancer risk.

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