FURTHER EVIDENCE AGAINST INHIBITION OF SYNTHESIS OF RAT LIVER TRYPTOPHAN PYRROLASE BY CHRONIC ETHANOL ADMINISTRATION

1979 ◽  
Keyword(s):  
Rat Liver ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Chronic Ethanol Administration ◽  
Tryptophan Pyrrolase

scholarly journals The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptophan pyrrolase and their resemblance to those of ethanol

1973 ◽  
Vol 135 (3) ◽  
pp. 555-557 ◽  
Author(s):  
Abdulla A.-B. Badawy ◽  
Myrddin Evans
Keyword(s):  
Enzyme Activity ◽  
Rat Liver ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Ethanol Inhibition ◽  
Chronic Ethanol Administration ◽  
Tryptophan Pyrrolase ◽  
Subsequent Withdrawal

Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.

Effects of chronic ethanol administration on rat liver proteasome activities: Relationship with oxidative stress

Hepatology ◽  
1999 ◽  
Vol 29 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Virginie Fataccioli ◽  
Evelyne Andraud ◽  
Monique Gentil ◽  
Samuel W. French ◽  
Helene Rouach
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Chronic Ethanol Administration

scholarly journals Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity

1979 ◽  
Vol 178 (3) ◽  
pp. 575-580 ◽  
Author(s):  
A A Badawy ◽  
N F Punjani ◽  
M Evans
Keyword(s):  
Methylene Blue ◽  
Rat Brain ◽  
Chronic Ethanol ◽  
Tryptophan Metabolism ◽  
Ethanol Administration ◽  
Chronic Ethanol Administration ◽  
Tryptophan Pyrrolase ◽  
Tryptophan Concentration ◽  
Phenazine Methosulphate ◽  
The Brain

1. Chronic ethanol administration enhances rat brain 5-hydroxytryptamine synthesis by increasing the availability of circulating tryptophan to the brain. This increased availability is not insulin-mediated or lipolysis-dependent. 2. Under these conditions, tryptophan accumulates in the liver and apo-(tryptophan pyrrolase) activity is completely abolished, but could be restored by administration of regenerators of liver NAD+ and/or NADP+. 3. All four regenerators used (fructose, Methylene Blue, phenazine methosulphate and sodium pyruvate) prevented the ethanol-induced increase in liver tryptophan concentration and the increased availability of tryptophan to the brain. 4. It is suggested that the enhancement of brain tryptophan metabolism by chronic ethanol administration is caused by the decreased hepatic tryptophan pyrrolase activity. The results are briefly discussed in relation to previous work with ethanol. 5. Fructose enhances the conversion of tryptophan into 5-hydroxyindol-3-ylacetic acid in brains of ethanol-treated rats, whereas Methylene Blue inhibits this conversion in both control and ethanol-treated animals.

Chronic ethanol administration affects oxydative stress by ischemia/reperfusion in rat liver

1998 ◽  
Vol 28 ◽  
pp. 220
Author(s):  
M Simoncini ◽  
A Gasbarrini ◽  
G. Addolorato ◽  
P Pasini ◽  
B Nardo ◽  
...  
Keyword(s):  
Rat Liver ◽  
Ischemia Reperfusion ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Oxydative Stress ◽  
Chronic Ethanol Administration
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