scholarly journals A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis

Rheumatology ◽  
2002 ◽  
Vol 41 (11) ◽  
pp. 1313-1317 ◽  
Author(s):  
E. Csernok
Keyword(s):  
Wegener’S Granulomatosis ◽  
Microscopic Polyangiitis ◽  
Critical Evaluation ◽  
Wegener's Granulomatosis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Proteinase 3

scholarly journals Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: Epitope analysis using synthetic peptides

2001 ◽  
Vol 59 (1) ◽  
pp. 147-159 ◽  
Author(s):  
Ymke M. Van Der Geld ◽  
Arjan Simpelaar ◽  
Ruurd Van Der Zee ◽  
Jan Willem Cohen Tervaert ◽  
Coen A. Stegeman ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Proteinase 3 ◽  
Epitope Analysis

A substrate‐based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen

2011 ◽  
Vol 25 (9) ◽  
pp. 3019-3031 ◽  
Author(s):  
Gwenhael Jégot ◽  
Chrystelle Derache ◽  
Sandrine Castella ◽  
Hichem Lahouassa ◽  
Elodie Pitois ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Specific Inhibitor ◽  
Wegener's Granulomatosis ◽  
Proteinase 3

Wegener's Granulomatosis and Antineutrophil Cytoplasmic Autoantibodies

1993 ◽  
Vol 102 (11) ◽  
pp. 906-908 ◽  
Author(s):  
John G. Batsakis ◽  
Adel K. El-Naggar
Keyword(s):  
Laboratory Test ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Proteinase 3 ◽  
Inflammatory Disorders ◽  
Serologic Tests ◽  
Criteria For Diagnosis ◽  
Antineutrophil Cytoplasmic Autoantibodies

Serologic tests for antineutrophil cytoplasmic autoantibodies can serve as markers for a number of necrotizing vasculitides and other inflammatory disorders. In the case of Wegener's granulomatosis, an immunofluorescent cytoplasmic pattern and immunoassay for proteinase 3 are quite specific for the disease and are capable of serving as additional criteria for diagnosis. As with any laboratory test, however, results are to be interpreted in the whole clinical and pathologic framework of the disease.

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