scholarly journals L-Dopa Therapy of Uremic and Idiopathic Restless Legs Syndrome: A Double-Blind, Crossover Trial

SLEEP ◽  
1995 ◽  
Vol 18 (8) ◽  
pp. 681-688 ◽  
Author(s):  
C. Trenkwalder ◽  
K. Stiasny ◽  
Th. Pollmächer ◽  
Th. Wetter ◽  
J. Schwarz ◽  
...  
SLEEP ◽  
1999 ◽  
Vol 22 (8) ◽  
pp. 1073-1081 ◽  
Author(s):  
Heike Beneš ◽  
Brigitte Kurella ◽  
Juergen Kummer ◽  
Joerg Kazenwadel ◽  
Roland Selzer ◽  
...  

1988 ◽  
Vol 24 (3) ◽  
pp. 455-458 ◽  
Author(s):  
Arthur S. Walters ◽  
Wayne A. Hening ◽  
Neil Kavey ◽  
Sudhansu Chokroverty ◽  
Steve Gidro-Frank

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii523-iii524
Author(s):  
Giorgos Sakkas ◽  
Christoforos Giannaki ◽  
Christina Karatzaferi ◽  
Georgios M. Hadjigeorgiou ◽  
Ioannis Stefanidis

BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e033815
Author(s):  
Tian-tian Ma ◽  
Zhikai Yang ◽  
Sainan Zhu ◽  
Jing-hong Zhao ◽  
Yi Li ◽  
...  

IntroductionRestless legs syndrome (RLS) is a common neurological sensorimotor disorder among patients with end stage renal disease. This clinical trial aimed to provide evidence on the efficacy and safety of pramipexole in patients with uremic RLS receiving peritoneal dialysis (PD).Methods and analysisThis is a 12-week, multicentre, randomised, double-blind, placebo-controlled clinical trial. In total, 104 patients with uremic RLS receiving PD will be enrolled from four hospitals and randomly assigned in a 1:1 ratio to either placebo or pramipexole. We will determine the efficacy of pramipexole in the improvement of International RLS Study Group Rating Scale as the primary outcome, while responder rates for other RLS scales at week 12, change from baseline to week 12 for psychological status, sleep disorder and quality of life and blood pressure represent the secondary outcomes.Ethics and disseminationThe study was approved by the ethics committees of Peking University First Hospital, Xinqiao hospital of Army Medical University, Cangzhou Center Hospital and Peking University Shenzhen Hospital. The results will be disseminated in peer-reviewed journals.Trial registration numberNCT03817554


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