The Genotoxic Potential of Linear Alkylbenzene Mixtures in a Short-Term Test Battery

1992 ◽  
Vol 18 (4) ◽  
pp. 540-548
Author(s):  
E. C. ROBINSON ◽  
R. S. NAIR
Keyword(s):  
Test Battery ◽  
Short Term ◽  
Linear Alkylbenzene ◽  
Genotoxic Potential ◽  
Short Term Test

DNA Fragmentation: Its Predictivity as a Short Term Test

1982 ◽  
pp. 121-154 ◽  
Author(s):  
Silvio Parodi ◽  
Maurizio Taningher ◽  
Leonardo Santi
Keyword(s):  
Dna Fragmentation ◽  
Short Term ◽  
Short Term Test

scholarly journals A study of the genotoxic potential of flavonoids using short-term bacterial assays.

1993 ◽  
Vol 40 (4) ◽  
pp. 549-554 ◽  
Author(s):  
H Czeczot ◽  
J Kusztelak
Keyword(s):  
Escherichia Coli ◽  
Salmonella Typhimurium ◽  
Mutagenic Effect ◽  
Short Term ◽  
Sos System ◽  
Genotoxic Potential ◽  
Sos Chromotest ◽  
Activation System ◽  
K 12 ◽  
Alkylate Dna

Genotoxic activities of flavonoids (quercetin, rhamnetin, isorhamnetin, apigenin, luteolin) were investigated using two short-term bacterial assays. In the "repair test" in Salmonella typhimurium (strains TA1538 uvrB- and TA1978 uvrB+) the flavonoids studied did not introduce any damage into the DNA recognized by UvrABC nuclease (correndonuclease II). The results of the SOS-Chromotest in Escherichia coli K-12 strains PQ37 (tag+, alk+) and PQ243 (tagA, alkA) indicated that flavonoids only weakly induced the SOS system. The addition of a liver activation system (S9 mix) did not increase the mutagenic effect of the flavonoids tested. Two compounds: rhamnetin, isorhamnetin and their putative metabolites formed in the presence of the S9 mix did not alkylate DNA at N-3 of adenine.

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