Boyd, Sir Robert (Lewis Fullarton), (1922–5 Feb. 2004), Professor of Physics in the University of London, 1962–83, then Emeritus; Director, Mullard Space Science Laboratory of Department of Physics and Astronomy of University College, London, 1965–83

2007 ◽  
Keyword(s):  
Space Science ◽  
Science Laboratory ◽  
University College ◽  
University College London ◽  
The University ◽  
Space Science Laboratory

THUR 037 Identification of biofluid markers of TDP-43 pathology

2018 ◽  
Vol 89 (10) ◽  
pp. A5.4-A6
Author(s):  
Shafei Rachelle ◽  
Foiani Martha ◽  
Heller Carolin ◽  
Heslegrave Amanda ◽  
Woollacott Ione ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Frontotemporal Dementia ◽  
Observational Studies ◽  
Healthy Controls ◽  
The Novel ◽  
Healthy Individuals ◽  
University College ◽  
University College London ◽  
The Mean ◽  
The University

IntroductionFrontotemporal dementia (FTD) is usually caused pathologically by either tau or TDP-43. Previous biofluid assays of TDP-43 have not so far proved to be sensitive or specific for identifying those cases with TDP-43 pathology.Material and methodsWe set out to investigate the novel TDP-43 Simoa assay (Quanterix) assay in both plasma and CSF in a cohort of patients recruited from the University College London FTD observational studies with known or likely TDP-43 pathology (17), non-TDP-43 pathology (13), and healthy controls (10).ResultsThe mean [standard deviation] plasma TDP-43 concentration was higher in those with likely TDP-43 pathology (155.1 [223.4] pg/ml) than those with non-TDP pathology (112.39 [252.9] pg/ml), and healthy controls (50.0 [23.1] pg/ml), but the differences between groups was non-significant, with substantial overlap in concentrations between all three groups. The mean CSF TDP-43 concentration was 2.9 [0.3] pg/ml in those with likely TDP-43 pathology, 2.8 [0.4] pg/ml in those with non-TDP pathology, and 3.1 [0.5] pg/ml in healthy controls. DiscussionThe assay tested in this study does not accurately distinguish between those with likely TDP-43 pathology and either disease controls or healthy individuals. There remains an urgent need to develop a better biofluid assay for pathological TDP-43.

Hotel-based ambulatory care for complex cancer patients: a review of the University College London Hospital experience

2012 ◽  
Vol 53 (12) ◽  
pp. 2397-2404 ◽  
Author(s):  
Jonathan Sive ◽  
Kirit M. Ardeshna ◽  
Simon Cheesman ◽  
Franel le Grange ◽  
Stephen Morris ◽  
...  
Keyword(s):  
Ambulatory Care ◽  
Cancer Patients ◽  
London Hospital ◽  
Hospital Experience ◽  
University College ◽  
University College London ◽  
The University
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