scholarly journals Expression and Possible Role of Muscle-Type Carnitine Palmitoyltransferase I during Sperm Development in the Rat1

1998 ◽  
Vol 59 (6) ◽  
pp. 1399-1405 ◽  
Author(s):  
Sean H. Adams ◽  
Victoria Esser ◽  
Nicholas F. Brown ◽  
Nancy H. Ing ◽  
Larry Johnson ◽  
...  
Keyword(s):  
Carnitine Palmitoyltransferase ◽  
Muscle Type ◽  
Sperm Development ◽  
Carnitine Palmitoyltransferase I

Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between

2001 ◽  
Vol 29 (2) ◽  
pp. 241-244 ◽  
Author(s):  
J. D. McGarry
Keyword(s):  
Acid Metabolism ◽  
Inhibitory Effect ◽  
Carnitine Palmitoyltransferase ◽  
Central Component ◽  
Body Tissues ◽  
Malonyl Coa ◽  
Sperm Development ◽  
Carnitine Palmitoyltransferase I ◽  
Cpt I

Although malonyl-CoA was first recognized as a central component in the regulation of hepatic ketogenesis, its inhibitory effect on mitochondrial carnitine palmitoyltransferase I (CPT I) has come to be viewed as a key element in fuel sensing in a variety of body tissues. This broadening role of the malonyl-CoA/CPT I partnership in the control of glucose and fatty acid metabolism, as well as current understanding of structure-function relationships surrounding the CPT proteins, are outlined. The intriguing question of whether CPT I has an important function in sperm development is also addressed briefly.

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