scholarly journals Modulated electro hyperthermia inhibits tumor progression in a triple negative mouse breast cancer model

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Péter Hamar ◽  
Lea Danics ◽  
Csaba Schvarcz ◽  
Zita Zolcsák ◽  
Zoltán Benyó ◽  
...  
2020 ◽  
Vol 21 (10) ◽  
pp. 3479 ◽  
Author(s):  
Elisa Roda ◽  
Fabrizio De Luca ◽  
Carmine Di Iorio ◽  
Daniela Ratto ◽  
Stella Siciliani ◽  
...  

Although medicinal mushroom extracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited the effect of a novel medicinal mushroom blend, namely Micotherapy U-care, in a 4T1 triple-negative mouse breast cancer model. Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice were generated by injecting 4T1 cells in both supplemented and non-supplemented mice. After sacrifice 35 days later, specific endpoints and pathological outcomes of the murine pulmonary tissue were evaluated. (i) Histopathological and ultrastructural analysis and (ii) immunohistochemical assessment of TGF-ß1, IL-6 and NOS2, COX2, SOD1 as markers of inflammation and oxidative stress were performed. The QoL was comparatively evaluated. Micotherapy U-care supplementation, starting before 4T1 injection and lasting until the end of the experiment, dramatically reduced the pulmonary metastases density, also triggering a decrease of fibrotic response, and reducing IL-6, NOS, and COX2 expression. SOD1 and TGF-ß1 results were also discussed. These findings support the valuable potential of Micotherapy U-care as adjuvant therapy in the critical management of triple-negative breast cancer.


Oncotarget ◽  
2017 ◽  
Vol 8 (46) ◽  
pp. 80804-80819 ◽  
Author(s):  
Teddy S. Nagaria ◽  
Changnian Shi ◽  
Charles Leduc ◽  
Victoria Hoskin ◽  
Soma Sikdar ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
L. Berrueta ◽  
J. Bergholz ◽  
D. Munoz ◽  
I. Muskaj ◽  
G. J. Badger ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
L. Berrueta ◽  
J. Bergholz ◽  
D. Munoz ◽  
I. Muskaj ◽  
G. J. Badger ◽  
...  

2014 ◽  
Vol 182 (2) ◽  
pp. 219 ◽  
Author(s):  
Inge Verbrugge ◽  
Alessia Gasparini ◽  
Nicole M. Haynes ◽  
Jim Hagekyriakou ◽  
Mara Galli ◽  
...  

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