scholarly journals Suppressing Sema3A expression in muscle satellite cells affects terminal Schwann cells after muscle and nerve injury

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Nasibeh Daneshvar ◽  
Ryuichi Tatsumi ◽  
Yuji Matsuyoshi ◽  
Judy Anderson
Keyword(s):  
Schwann Cells ◽  
Nerve Injury ◽  
Satellite Cells ◽  
Muscle Satellite Cells ◽  
Terminal Schwann Cells

scholarly journals S100ß and fibroblast growth factor-2 are present in cultured Schwann cells and may exert paracrine actions on the peripheral nerve injury

2008 ◽  
Vol 23 (6) ◽  
pp. 555-560 ◽  
Author(s):  
Tatiana Duobles ◽  
Thais de Sousa Lima ◽  
Beatriz de Freitas Azevedo Levy ◽  
Gerson Chadi
Keyword(s):  
Growth Factor ◽  
Sciatic Nerve ◽  
Fibroblast Growth Factor ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Satellite Cells ◽  
Peripheral Nerves ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Cultured Schwann Cells

PURPOSE: The neurotrophic factor fibroblast growth factor-2 (FGF-2, bFGF) and Ca++ binding protein S100ß are expressed by the Schwann cells of the peripheral nerves and by the satellite cells of the dorsal root ganglia (DRG). Recent studies have pointed out the importance of the molecules in the paracrine mechanisms related to neuronal maintenance and plasticity of lesioned motor and sensory peripheral neurons. Moreover, cultured Schwann cells have been employed experimentally in the treatment of central nervous system lesions, in special the spinal cord injury, a procedure that triggers an enhanced sensorymotor function. Those cells have been proposed to repair long gap nerve injury. METHODS: Here we used double labeling immunohistochemistry and Western blot to better characterize in vitro and in vivo the presence of the proteins in the Schwann cells and in the satellite cells of the DRG as well as their regulation in those cells after a crush of the rat sciatic nerve. RESULTS: FGF-2 and S100ß are present in the Schwann cells of the sciatic nerve and in the satellite cells of the DRG. S100ß positive satellite cells showed increased size of the axotomized DRG and possessed elevated amount of FGF-2 immunoreactivity. Reactive satellite cells with increased FGF-2 labeling formed a ring-like structure surrounding DRG neuronal cell bodies.Reactive S100ß positive Schwann cells of proximal stump of axotomized sciatic nerve also expressed higher amounts of FGF-2. CONCLUSION: Reactive peripheral glial cells synthesizing FGF-2 and S100ß may be important in wound repair and restorative events in the lesioned peripheral nerves.

scholarly journals Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling during Reinnervation following Nerve Injury

2014 ◽  
Vol 34 (18) ◽  
pp. 6323-6333 ◽  
Author(s):  
H. Kang ◽  
L. Tian ◽  
M. Mikesh ◽  
J. W. Lichtman ◽  
W. J. Thompson
Keyword(s):  
Schwann Cells ◽  
Nerve Injury ◽  
Neuromuscular Synapse ◽  
Terminal Schwann Cells

GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury

Neuroreport ◽  
1996 ◽  
Vol 7 (4) ◽  
pp. 857-860 ◽  
Author(s):  
H. Hammarberg ◽  
F. Piehl ◽  
S. Cullheim ◽  
J. Fjell ◽  
T Hökfelt ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Satellite Cells ◽  
Sciatic Nerve Injury

Terminal Schwann cells guide the reinnervation of muscle after nerve injury

2003 ◽  
Vol 32 (5-8) ◽  
pp. 975-985 ◽  
Author(s):  
Hyuno Kang ◽  
Le Tian ◽  
Wesley Thompson
Keyword(s):  
Schwann Cells ◽  
Nerve Injury ◽  
Terminal Schwann Cells
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