Role of organic anion transporter 3 (Oat3) in the renal transport of glutathione (GSH)

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Lawrence H. Lash ◽  
David A. Putt ◽  
Feng Xu ◽  
Larry H. Matherly
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Renal Transport ◽  
Anion Transporter ◽  
Organic Anion Transporter 3

scholarly journals Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney

2002 ◽  
Vol 61 (5) ◽  
pp. 1760-1768 ◽  
Author(s):  
Tsuneo Deguchi ◽  
Sumio Ohtsuki ◽  
Masaki Otagiri ◽  
Hitomi Takanaga ◽  
Hiroshi Asaba ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Indoxyl Sulfate ◽  
Anion Transporter ◽  
Organic Anion Transporter 3

scholarly journals Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione

2007 ◽  
Vol 170 (2) ◽  
pp. 124-134 ◽  
Author(s):  
Lawrence H. Lash ◽  
David A. Putt ◽  
Feng Xu ◽  
Larry H. Matherly
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
Organic Anion Transporter 3

RENAL TRANSPORT OF ORGANIC COMPOUNDS MEDIATED BY MOUSE ORGANIC ANION TRANSPORTER 3 (MOAT3): FURTHER SUBSTRATE SPECIFICITY OF MOAT3

2004 ◽  
Vol 32 (5) ◽  
pp. 479-483 ◽  
Author(s):  
Yasuna Kobayashi ◽  
Naomi Ohshiro ◽  
Ayumi Tsuchiya ◽  
Noriko Kohyama ◽  
Masayuki Ohbayashi ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Organic Compounds ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Renal Transport ◽  
Anion Transporter ◽  
Organic Anion Transporter 3

scholarly journals The activity of organic anion transporter-3: Role of dexamethasone

2018 ◽  
Vol 136 (2) ◽  
pp. 79-85 ◽  
Author(s):  
Haoxun Wang ◽  
Chenchang Liu ◽  
Guofeng You
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
Organic Anion Transporter 3

scholarly journals Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS)

2010 ◽  
Vol 88 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Matthias Rödiger ◽  
Xiaohong Zhang ◽  
Bernhard Ugele ◽  
Nikolaus Gersdorff ◽  
Stephen H. Wright ◽  
...  
Keyword(s):  
Organic Anion ◽  
Proximal Tubules ◽  
Organic Anion Transporter ◽  
Hek293 Cells ◽  
Renal Transport ◽  
Renal Proximal Tubules ◽  
Metal Chelator ◽  
Anion Transporter ◽  
Intact Rabbit ◽  
Organic Anion Transporter 3

Recent investigations involving intact rabbit renal proximal tubules indicated that organic anion transporter 3 (OAT3) may be involved in the transport of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Therefore, we evaluated the interaction of OAT3 with DMPS to determine the effect of OAT3 on basolateral DMPS uptake. We used stably transfected HEK293 cells expressing human and rabbit orthologs of the exchanger OAT1 and OAT3. Using 6-carboxyfluorescein (6-CF) as a substrate, the IC50 determinations for reduced DMPS (DMPSH) revealed a stronger interaction with OAT1 than with OAT3 (rbOAT1, 123.3 ± 13.7; hOAT1, 85.1 ± 8.8; rbOAT3, 171.7 ± 22.3; and hOAT3, 172.2 ± 36.4 µmol/L). However, inhibition of 6-CF uptake by the oxidized form of DMPS (DMPSS), the main form of DMPS in the blood, showed a greater affinity for OAT3 (rbOAT1, 237.4 ± 23; hOAT1, 104.6 ± 13.1; rbOAT3, 52.4 ± 7.6; and hOAT3, 31.6 ± 6.6 µmol/L). To determine whether DMPSH and DMPSS are substrates for OAT3, we performed efflux studies with [14C]glutarate and inwardly directed gradients of glutarate. The inhibitors trans-stimulated the efflux of [14C]glutarate, suggesting that OAT3 may be able to transport both forms of DMPS. On the basis of the substantial interaction of OAT3 with DMPSS, we conclude that OAT3 represents the dominant basolateral player in renal detoxification processes resulting from use of DMPS.

scholarly journals Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E2 Transport Pathway

2007 ◽  
Vol 103 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Sirinun Nilwarangkoon ◽  
Naohiko Anzai ◽  
Katsuko Shiraya ◽  
Erkang Yu ◽  
Rafiqul Islam ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Transport Pathway ◽  
Anion Transporter ◽  
Organic Anion Transporter 3
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