renal proximal tubules
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iScience ◽  
2021 ◽  
pp. 102928
Author(s):  
Jakub Jankowski ◽  
Hye Kyung Lee ◽  
Julia Wilflingseder ◽  
Lothar Hennighausen


2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Ernest L. Vallorz ◽  
Karen Blohm-Mangone ◽  
Rick G. Schnellmann ◽  
Heidi M. Mansour


2021 ◽  
Author(s):  
Masayoshi Kukida ◽  
Lei Cai ◽  
Dien Ye ◽  
Hisashi Sawada ◽  
Yuriko Katsumata ◽  
...  

AGT (Angiotensinogen) is the unique substrate of the renin-angiotensin system. Liver is the primary source of circulating AGT. The present study determined whether hepatocyte-derived AGT regulates renal AGT accumulation by injecting ASO (antisense oligonucleotides) targeting hepatocyte-derived AGT (GalNAc AGT ASO) into female cynomolgus monkeys. Hepatocyte-specific inhibition of AGT led to profound reductions of plasma AGT concentrations. AGT protein in S1 and S2 of renal proximal tubules was greatly diminished by GalNAc AGT ASO. Given the similarity between nonhuman primates and human, our findings support the notion that renal AGT is predominantly derived from liver, and liver regulates renal angiotensin II production in humans.





Gene ◽  
2020 ◽  
Vol 752 ◽  
pp. 144790
Author(s):  
Lin Huang ◽  
Jinling Liao ◽  
Juan He ◽  
Siqiong Pan ◽  
Haiying Zhang ◽  
...  


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 473-P
Author(s):  
JIA LI ◽  
MADHAVI JAGDISH RANE ◽  
LU CAI ◽  
YI TAN


2020 ◽  
Vol 97 (2) ◽  
pp. 316-326 ◽  
Author(s):  
Motonobu Nakamura ◽  
Hiroyuki Tsukada ◽  
George Seki ◽  
Nobuhiko Satoh ◽  
Tomohito Mizuno ◽  
...  


Metabolomics ◽  
2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Guanshi Zhang ◽  
Jialing Zhang ◽  
Rachel J. DeHoog ◽  
Subramaniam Pennathur ◽  
Christopher R. Anderton ◽  
...  


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