renal proximal tubules
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scholarly journals JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules

iScience ◽  
2021 ◽  
pp. 102928
Author(s):  
Jakub Jankowski ◽  
Hye Kyung Lee ◽  
Julia Wilflingseder ◽  
Lothar Hennighausen
Keyword(s):  
Proximal Tubules ◽  
Jak Inhibitors ◽  
Renal Proximal Tubules

Formoterol PLGA-PEG Nanoparticles Induce Mitochondrial Biogenesis in Renal Proximal Tubules

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Ernest L. Vallorz ◽  
Karen Blohm-Mangone ◽  
Rick G. Schnellmann ◽  
Heidi M. Mansour
Keyword(s):  
Mitochondrial Biogenesis ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

scholarly journals Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived

2021 ◽  
Author(s):  
Masayoshi Kukida ◽  
Lei Cai ◽  
Dien Ye ◽  
Hisashi Sawada ◽  
Yuriko Katsumata ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Antisense Oligonucleotides ◽  
Nonhuman Primates ◽  
Primary Source ◽  
Renin Angiotensin System ◽  
Proximal Tubules ◽  
Specific Inhibition ◽  
Angiotensin System ◽  
Renal Proximal Tubules ◽  
Cynomolgus Monkeys

AGT (Angiotensinogen) is the unique substrate of the renin-angiotensin system. Liver is the primary source of circulating AGT. The present study determined whether hepatocyte-derived AGT regulates renal AGT accumulation by injecting ASO (antisense oligonucleotides) targeting hepatocyte-derived AGT (GalNAc AGT ASO) into female cynomolgus monkeys. Hepatocyte-specific inhibition of AGT led to profound reductions of plasma AGT concentrations. AGT protein in S1 and S2 of renal proximal tubules was greatly diminished by GalNAc AGT ASO. Given the similarity between nonhuman primates and human, our findings support the notion that renal AGT is predominantly derived from liver, and liver regulates renal angiotensin II production in humans.

Effect of amphotericin B‐deoxycholate (Fungizone) on the mitochondria of Wistar rats' renal proximal tubules cells

2021 ◽  
Author(s):  
Shehab Ahmed Alenazi ◽  
Ekramy Elmorsy ◽  
Ayat Al‐Ghafari ◽  
Amr El‐Husseini
Keyword(s):  
Amphotericin B ◽  
Wistar Rats ◽  
Proximal Tubules ◽  
Renal Proximal Tubules ◽  
Amphotericin B Deoxycholate

Single-cell profiling reveals sex diversity in human renal proximal tubules

Gene ◽  
2020 ◽  
Vol 752 ◽  
pp. 144790
Author(s):  
Lin Huang ◽  
Jinling Liao ◽  
Juan He ◽  
Siqiong Pan ◽  
Haiying Zhang ◽  
...  
Keyword(s):  
Single Cell ◽  
Proximal Tubules ◽  
Renal Proximal Tubules ◽  
Single Cell Profiling

473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 473-P
Author(s):  
JIA LI ◽  
MADHAVI JAGDISH RANE ◽  
LU CAI ◽  
YI TAN
Keyword(s):  
Proximal Tubules ◽  
Hdac Inhibition ◽  
Renal Proximal Tubules ◽  
Jnk Activation

Insulin promotes sodium transport but suppresses gluconeogenesis via distinct cellular pathways in human and rat renal proximal tubules

2020 ◽  
Vol 97 (2) ◽  
pp. 316-326 ◽  
Author(s):  
Motonobu Nakamura ◽  
Hiroyuki Tsukada ◽  
George Seki ◽  
Nobuhiko Satoh ◽  
Tomohito Mizuno ◽  
...  
Keyword(s):  
Sodium Transport ◽  
Proximal Tubules ◽  
Renal Proximal Tubules ◽  
Cellular Pathways

scholarly journals DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules

Metabolomics ◽  
2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Guanshi Zhang ◽  
Jialing Zhang ◽  
Rachel J. DeHoog ◽  
Subramaniam Pennathur ◽  
Christopher R. Anderton ◽  
...  
Keyword(s):  
Mitochondrial Membrane ◽  
Proximal Tubules ◽  
Renal Proximal Tubules ◽  
Membrane Components ◽  
Lipid Abnormalities
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