scholarly journals Role of the Toll‐like receptor adaptor protein, TIRAP in regulation of gene expression of hepatic drug metabolizing enzymes

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Romi Ghose ◽  
Tao Guo
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Adaptor Protein ◽  
Drug Metabolizing Enzymes ◽  
Toll Like Receptor ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

scholarly journals Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

Life Sciences ◽  
2011 ◽  
Vol 89 (1-2) ◽  
pp. 57-64 ◽  
Author(s):  
Romi Ghose ◽  
Ozozoma Omoluabi ◽  
Adarsh Gandhi ◽  
Pranav Shah ◽  
Kelley Strohacker ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Regulation Of Gene Expression ◽  
Drug Metabolizing Enzymes ◽  
High Fat ◽  
Metabolizing Enzymes

scholarly journals Central Role of Toll-Like Receptor 4 Signaling and Host Defense in Experimental Pneumonia Caused by Gram-Negative Bacteria

2005 ◽  
Vol 73 (1) ◽  
pp. 532-545 ◽  
Author(s):  
Jill R. Schurr ◽  
Erana Young ◽  
Pat Byrne ◽  
Chad Steele ◽  
Judd E. Shellito ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adaptor Protein ◽  
Mouse Strains ◽  
Gram Negative Bacteria ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Tlr4 Signaling ◽  
Gram Negative ◽  
Experimental Pneumonia

ABSTRACT Toll-like receptor 4 (TLR4) has been identified as a receptor for lipopolysaccharide. However, the precise role of TLR4 in regulating gene expression in response to an infection caused by gram-negative bacteria has not been fully elucidated. The role of TLR4 signaling in coordinating gene expression was assessed by gene expression profiling in lung tissue in a mouse model of experimental pneumonia with a low-dose infection of Klebsiella pneumoniae. We analyzed four mouse strains: C57BL/6 mice, which are resistant to bacterial dissemination; 129/SvJ mice, which are susceptible; C3H/HeJ mice, which are susceptible and have defective TLR4 signaling; and their respective control strain, C3H/HeN (intermediate resistance). At 4 h after infection, C57BL/6 and C3H/HeN mice demonstrated the greatest number of genes, with 67 shared induced genes which were TLR4 dependent and highly associated with the resistance phenotype. These genes included cytokine and chemokine genes required for neutrophil activation or recruitment, growth factor receptors, MyD88 (a critical adaptor protein for TLR signaling), and adhesion molecules. TLR4 signaling accounted for over 74% of the gene expression in the C3H background. These data suggest that early TLR4 signaling controls the vast majority of gene expression in the lung in response to an infection caused by gram-negative bacteria and that this subsequent gene expression determines survival of the host.

Regulation of gene expression of various Phase I and Phase II drug-metabolizing enzymes by tamoxifen in rat liver

1996 ◽  
Vol 52 (10) ◽  
pp. 1561-1568 ◽  
Author(s):  
Edward T. Hellriegel ◽  
George A. Matwyshyn ◽  
Peiwen Fei ◽  
Konstantin H. Dragnev ◽  
Raymond W. Nims ◽  
...  
Keyword(s):  
Gene Expression ◽  
Phase I ◽  
Rat Liver ◽  
Phase Ii ◽  
Regulation Of Gene Expression ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes
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