scholarly journals In vivo loss of estrogen increases voltage‐gated calcium channel function in mesenteric arterial smooth muscle cells

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Charmain A Fernando ◽  
William R. Gray ◽  
Azida Walker ◽  
Brent J.F. Hill
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Calcium Channel ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Voltage Gated ◽  
Channel Function ◽  
Arterial Smooth Muscle Cells ◽  
Voltage Gated Calcium Channel

scholarly journals Cholesterol increases the L-type voltage-sensitive calcium channel current in arterial smooth muscle cells.

1992 ◽  
Vol 71 (4) ◽  
pp. 1008-1014 ◽  
Author(s):  
L Sen ◽  
R A Bialecki ◽  
E Smith ◽  
T W Smith ◽  
W S Colucci
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Calcium Channel ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Channel Current ◽  
Arterial Smooth Muscle Cells

Mobilization of intracellular Ca2+ by endothelin-1 in rat intrapulmonary arterial smooth muscle cells

2000 ◽  
Vol 278 (1) ◽  
pp. L157-L164 ◽  
Author(s):  
Larissa A. Shimoda ◽  
J. T. Sylvester ◽  
James S. K. Sham
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Voltage Gated ◽  
Endothelin 1 ◽  
Intracellular Release ◽  
Intracellular Ca ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells

Endothelin-1 (ET-1) increases intracellular Ca2+ concentration ([Ca2+]i) in pulmonary arterial smooth muscle cells (PASMCs); however, the mechanisms for Ca2+ mobilization are not clear. We determined the contributions of extracellular influx and intracellular release to the ET-1-induced Ca2+ response using Indo 1 fluorescence and electrophysiological techniques. Application of ET-1 (10−10 to 10−8 M) to transiently (24–48 h) cultured rat PASMCs caused concentration-dependent increases in [Ca2+]i. At 10−8 M, ET-1 caused a large, transient increase in [Ca2+]i (>1 μM) followed by a sustained elevation in [Ca2+]i(<200 nM). The ET-1-induced increase in [Ca2+]i was attenuated (<80%) by extracellular Ca2+ removal; by verapamil, a voltage-gated Ca2+-channel antagonist; and by ryanodine, an inhibitor of Ca2+ release from caffeine-sensitive stores. Depleting intracellular stores with thapsigargin abolished the peak in [Ca2+]i, but the sustained phase was unaffected. Simultaneously measuring membrane potential and [Ca2+]i indicated that depolarization preceded the rise in [Ca2+]i. These results suggest that ET-1 initiates depolarization in PASMCs, leading to Ca2+influx through voltage-gated Ca2+ channels and Ca2+ release from ryanodine- and inositol 1,4,5-trisphosphate-sensitive stores.

Suppression of voltage-gated K+ channels by darifenacin in coronary arterial smooth muscle cells

2021 ◽  
Vol 891 ◽  
pp. 173707
Author(s):  
Mi Seon Seo ◽  
Jin Ryeol An ◽  
Hee Seok Jung ◽  
Minji Kang ◽  
Ryeon Heo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
K Channels ◽  
Voltage Gated ◽  
Arterial Smooth Muscle Cells

scholarly journals Human Immunodeficiency Virus (HIV) Infects Human Arterial Smooth Muscle Cells in Vivo and in Vitro

2008 ◽  
Vol 172 (4) ◽  
pp. 1100-1111 ◽  
Author(s):  
Eliseo A. Eugenin ◽  
Susan Morgello ◽  
Mary E. Klotman ◽  
Arevik Mosoian ◽  
Patrick A. Lento ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Immunodeficiency Virus ◽  
Arterial Smooth Muscle Cells

Prostaglandin 12 reduces activation of human arterial smooth muscle cells in-vivo

1987 ◽  
Vol 33 (6) ◽  
pp. 915-918 ◽  
Author(s):  
Helmut Sinzinger ◽  
Thomas Zidek ◽  
Peter Fitscha ◽  
John O'Grady ◽  
Otto Wagner ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Arterial Smooth Muscle Cells
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