Development of an Acute Withdrawal Syndrome Following the Cessation of Intrathecal Baclofen in a Patient with Spasticity

1992 ◽  
Vol 77 (5) ◽  
pp. 1048-1050 ◽  
Author(s):  
Richard N. Siegfried ◽  
Louis Jacobson ◽  
Charles Chabal
Keyword(s):  
Withdrawal Syndrome ◽  
Intrathecal Baclofen ◽  
Acute Withdrawal

scholarly journals The Intrathecal Baclofen Withdrawal Syndrome: A Systematic Review

2010 ◽  
Vol 8 (7) ◽  
pp. 537
Author(s):  
W.R. Muirhead ◽  
N. Baylem ◽  
I. Jalloh ◽  
M. Vloeberghs
Keyword(s):  
Systematic Review ◽  
Withdrawal Syndrome ◽  
Intrathecal Baclofen ◽  
Baclofen Withdrawal

Remifentanil in the Intensive Care Unit: Tolerance and Acute Withdrawal Syndrome after Prolonged Sedation

2005 ◽  
Vol 102 (6) ◽  
pp. 1281-1282 ◽  
Author(s):  
Bernard Delvaux ◽  
Yves Ryckwaert ◽  
Michel Van Boven ◽  
Marc De Kock ◽  
Xavier Capdevila
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Withdrawal Syndrome ◽  
Acute Withdrawal ◽  
Prolonged Sedation

Prevention of Intrathecal Baclofen Withdrawal Syndrome

2009 ◽  
Vol 34 (6) ◽  
pp. 600-602 ◽  
Author(s):  
Anke Bellinger ◽  
Rapipen Siriwetchadarak ◽  
Richard Rosenquist ◽  
Jeremy D.W. Greenlee
Keyword(s):  
Withdrawal Syndrome ◽  
Intrathecal Baclofen ◽  
Baclofen Withdrawal

scholarly journals Management of Tizanidine Withdrawal Syndrome: A Case Report

2018 ◽  
Vol 11 ◽  
pp. 117954761875802 ◽  
Author(s):  
A Suárez-Lledó ◽  
A Padullés ◽  
T Lozano ◽  
S Cobo-Sacristán ◽  
M Colls ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Withdrawal Syndrome ◽  
Dose Titration ◽  
Potential Side Effect ◽  
Acute Withdrawal ◽  
Reflex Tachycardia ◽  
Adrenergic Activity ◽  
The Central Nervous System ◽  
Require Dose

Most drugs that act on the central nervous system (CNS) require dose titration to avoid withdrawal syndrome. Tizanidine withdrawal syndrome is caused by adrenergic discharge due to its α2-agonist mechanism and is characterized by hypertension, reflex tachycardia, hypertonicity, and anxiety. Although tizanidine withdrawal syndrome is mentioned as a potential side effect of cessation, it is not common and there have been few reports. We present the case of a 31-year-old woman with tizanidine withdrawal syndrome after discontinuing medication prescribed for a muscle contracture (tizanidine). She showed high adrenergic activity with nausea, vomiting, generalized tremor, dysthermia, hypertension, and tachycardia. Symptoms were reversed and successful reweaning was achieved by restarting tizanidine followed by slow downward titration. Withdrawal syndrome should be considered when drugs targeting the CNS are suddenly stopped. Weaning regimens should be closely monitored for acute withdrawal reactions.

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